产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
AIRE Monoclonal Antibody (5H12), eFluor™ 660, eBioscience
目录 :
50-5934-80
规格 :
25微克
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
efluor 660
克隆名称 :
5H12
反应物种 :
小鼠
应用 :
免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 16
参考文献
Fujimori S, Ohigashi I, Abe H, Matsushita Y, Katagiri T, Taketo M, et al. Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development. elife. 2022;11: pubmed 出版商
Teng F, Tach xf3 Pi xf1 ot R, Sung B, Farber D, Worgall S, Hammad H, et al. ILC3s control airway inflammation by limiting T cell responses to allergens and microbes. Cell Rep. 2021;37:110051 pubmed 出版商
Goldfarb Y, Givony T, Kadouri N, Dobe x161 J, Peligero Cruz C, Zalayat I, et al. Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation. J Exp Med. 2021;218: pubmed 出版商
Zhang Q, Liang Z, Zhang J, Lei T, Dong X, Su H, et al. Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance. Front Cell Dev Biol. 2021;9:655552 pubmed 出版商
Farini A, Sitzia C, Villa C, Cassani B, Tripodi L, Legato M, et al. Defective dystrophic thymus determines degenerative changes in skeletal muscle. Nat Commun. 2021;12:2099 pubmed 出版商
Ohigashi I, Tanaka Y, Kondo K, Fujimori S, Kondo H, Palin A, et al. Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells. Cell Rep. 2019;29:2901-2916.e6 pubmed 出版商
Wang H, Hogquist K. CCR7 defines a precursor for murine iNKT cells in thymus and periphery. elife. 2018;7: pubmed 出版商
Liang Z, Zhang L, Su H, Luan R, Na N, Sun L, et al. MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance. Autophagy. 2017;: pubmed 出版商
Ohigashi I, Ohte Y, Setoh K, Nakase H, Maekawa A, Kiyonari H, et al. A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production. JCI Insight. 2017;2: pubmed 出版商
Takahashi T, Asano Y, Sugawara K, Yamashita T, Nakamura K, Saigusa R, et al. Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma. J Exp Med. 2017;214:1129-1151 pubmed 出版商
Bansal K, Yoshida H, Benoist C, Mathis D. The transcriptional regulator Aire binds to and activates super-enhancers. Nat Immunol. 2017;18:263-273 pubmed 出版商
McCarthy N, Cowan J, Nakamura K, Bacon A, Baik S, White A, et al. Osteoprotegerin-Mediated Homeostasis of Rank+ Thymic Epithelial Cells Does Not Limit Foxp3+ Regulatory T Cell Development. J Immunol. 2015;195:2675-82 pubmed 出版商
Coder B, Wang H, Ruan L, Su D. Thymic involution perturbs negative selection leading to autoreactive T cells that induce chronic inflammation. J Immunol. 2015;194:5825-37 pubmed 出版商
Waterfield M, Khan I, Cortez J, Fan U, Metzger T, Greer A, et al. The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nat Immunol. 2014;15:258-65 pubmed 出版商
Irla M, Guenot J, Sealy G, Reith W, Imhof B, Serge A. Three-dimensional visualization of the mouse thymus organization in health and immunodeficiency. J Immunol. 2013;190:586-96 pubmed 出版商
Rossi S, Kim M, Leibbrandt A, Parnell S, Jenkinson W, Glanville S, et al. RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med. 2007;204:1267-72 pubmed
产品信息
产品类型 :
抗体
产品名称 :
AIRE Monoclonal Antibody (5H12), eFluor™ 660, eBioscience
目录# :
50-5934-80
规格 :
25微克
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
大鼠
反应物种 :
小鼠
应用 :
Flow Cytometry: Assay-Dependent, Immunocytochemistry: 10 µg/mL, Immunohistochemistry (Frozen): 10 µg/mL
物种 :
小鼠
克隆 :
5H12
抗体亚型 :
IgG2c, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression. A nuclear protein, AIRE is a 545 amino acid protein with an HSR domain, two PHD type zinc fingers, and a SAND domain, and may be present in soluble high-molecular-weight complexes. It may form homodimer, homotetramer and also nuclear bodies and interacts with the transcriptional coactivator CBP and CREBBP. Three isoforms of AIRE are reported and one of them is predicted to be a candidate for nuclear-mediated decay (NMD). AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity. Defects in AIRE are responsible for the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-Dependent, Immunocytochemistry: 10 µg/mL, Immunohistochemistry (Frozen): 10 µg/mL
别名 :
Aire; AIRE protein; AIRE1; APECED; APECED protein; APECED protein homolog; APS1; APSI; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; Autoimmune regulator; autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); autoimmune regulator AIRE1a; LOW QUALITY PROTEIN: autoimmune regulator; OTTHUMP00000109529; PGA1
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国