产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-17A Monoclonal Antibody (eBio64CAP17), eFluor™ 660, eBioscience
目录 :
50-7178-42
规格 :
100试验
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
efluor 660
克隆名称 :
eBio64CAP17
反应物种 :
人类
应用 :
流式细胞仪
更多信息或购买 :
文章摘录数: 79
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 s4c
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Vagenas P, Aravantinou M, Williams V, Jasny E, Piatak M, Lifson J, et al. A tonsillar PolyICLC/AT-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation. PLoS ONE. 2010;5:e12891 pubmed 出版商
DeForge L, Loyet K, Delarosa D, Chinn J, Zamanian F, Chuntharapai A, et al. Evaluation of heterophilic antibody blocking agents in reducing false positive interference in immunoassays for IL-17AA, IL-17FF, and IL-17AF. J Immunol Methods. 2010;362:70-81 pubmed 出版商
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Ersvaer E, Liseth K, Skavland J, Gjertsen B, Bruserud Ø. Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells. BMC Immunol. 2010;11:38 pubmed 出版商
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Klatt N, Harris L, Vinton C, Sung H, Briant J, Tabb B, et al. Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection. Mucosal Immunol. 2010;3:387-98 pubmed 出版商
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Chaudhary N, Staab J, Marr K. Healthy human T-Cell Responses to Aspergillus fumigatus antigens. PLoS ONE. 2010;5:e9036 pubmed 出版商
Jeffery L, Burke F, Mura M, Zheng Y, Qureshi O, Hewison M, et al. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol. 2009;183:5458-67 pubmed 出版商
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Lim H, Lee J, Hillsamer P, Kim C. Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells. J Immunol. 2008;180:122-9 pubmed
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产品信息
产品类型 :
抗体
产品名称 :
IL-17A Monoclonal Antibody (eBio64CAP17), eFluor™ 660, eBioscience
目录# :
50-7178-42
规格 :
100试验
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 5 µL (0.125 µg)/test
物种 :
人类
克隆 :
eBio64CAP17
抗体亚型 :
IgG1, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO).
格式 :
液体
应用w/稀释 :
Flow Cytometry: 5 µL (0.125 µg)/test
别名 :
Ctla8; CTLA-8; cytokine; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; il 17; Il17; IL-17; IL17A; IL-17a; ILN; Interleukin; interleukin 17; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17 precursor; interleukin 17A; interleukin-17; Interleukin17A; interleukin-17A; R-IL-17-A
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国