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抗体

EGF Polyclonal Antibody, PeproTech

500-P45毫克

1毫克

美国1836.00

多克隆

domestic rabbit

未共轭

免疫印迹, 酶联免疫吸附测定

EGF Polyclonal Antibody, PeproTech

500-P45毫克

1毫克

美国1836.00

多克隆

抗原亲和色谱

兔

人类

ELISA: 0.5-2.0 µg/mL, Western Blot: 0.1-0.2 µg/mL

人类

-20°C

EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.

E.coli-derived Recombinant Human EGF

冻干

ELISA: 0.5-2.0 µg/mL, Western Blot: 0.1-0.2 µg/mL

AI790464; beta-urogastrone; EGF; Epidermal growth factor; epidermal growth factor (beta-urogastrone); epidermal growth factor precursor; H-EGF; HOMG4; Pro-epidermal growth factor; Pro-epidermal growth factor precursor (EGF); sb:eu639; URG; Urogastrone