产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
LAMP-2A多克隆抗体(AMC2)
目录 :
51-2200
规格 :
100微克
价格 :
375美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
AMC2
反应物种 :
小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 23
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 小鼠; 1:1000; 图 st10
  • 免疫组化-石蜡切片; 大鼠; 1:100; 图 st10
Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed 出版商
  • 免疫印迹; 小鼠; 1:4000; 图 3a
Vodicka P, Chase K, Iuliano M, Tousley A, Valentine D, Sapp E, et al. Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice. J Huntingtons Dis. 2016;5:249-260 pubmed
  • 免疫印迹; 小鼠; 1:1000; 图 6
Basisty N, Dai D, Gagnidze A, Gitari L, Fredrickson J, Maina Y, et al. Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: 'reverse' antagonistic pleiotropy?. Aging Cell. 2016;15:634-45 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 s6
Shimshek D, Jacobson L, Kolly C, Zamurovic N, Balavenkatraman K, Morawiec L, et al. Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice. Sci Rep. 2016;6:21917 pubmed 出版商
Lo Dico A, Salvatore D, Martelli C, Ronchi D, Diceglie C, Lucignani G, et al. Intracellular Redox-Balance Involvement in Temozolomide Resistance-Related Molecular Mechanisms in Glioblastoma. Cells. 2019;8: pubmed 出版商
Kirchner P, Bourdenx M, Madrigal Matute J, Tiano S, Díaz A, Bartholdy B, et al. Proteome-wide analysis of chaperone-mediated autophagy targeting motifs. PLoS Biol. 2019;17:e3000301 pubmed 出版商
Wu Z, Geng Y, Lu X, Shi Y, Wu G, Zhang M, et al. Chaperone-mediated autophagy is involved in the execution of ferroptosis. Proc Natl Acad Sci U S A. 2019;116:2996-3005 pubmed 出版商
Lee S, Shin S, Zhong P, Kim H, Kim D, Kim J, et al. Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes. Nat Commun. 2018;9:3434 pubmed 出版商
Trachsel Moncho L, Benlloch Navarro S, Fernández Carbonell Á, Ramírez Lamelas D, Olivar T, Silvestre D, et al. Oxidative stress and autophagy-related changes during retinal degeneration and development. Cell Death Dis. 2018;9:812 pubmed 出版商
Sakurai T, Kamio K, Sasaki K, Nishimoto T, Yamaguchi J, Sasaki M, et al. Imaging Mass Microscopy of Kidneys from Azithromycin-Treated Rats with Phospholipidosis. Am J Pathol. 2018;188:1993-2003 pubmed 出版商
Ma J, Snook S, Garrovillo S, Johnson C, La D. An Immunohistochemical Investigation of Renal Phospholipidosis and Toxicity in Rats. Int J Toxicol. 2017;36:386-394 pubmed 出版商
Kim Y, Hood D. Regulation of the autophagy system during chronic contractile activity-induced muscle adaptations. Physiol Rep. 2017;5: pubmed 出版商
Zhang J, Johnson J, He J, Napolitano G, Ramadass M, Rocca C, et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J Biol Chem. 2017;292:10328-10346 pubmed 出版商
Into T, Horie T, Inomata M, Gohda J, Inoue J, Murakami Y, et al. Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88. Sci Rep. 2017;7:1009 pubmed 出版商
Gomes L, Menck C, Cuervo A. Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation. Autophagy. 2017;13:928-940 pubmed 出版商
Braendli Baiocco A, Festag M, Dumong Erichsen K, Persson R, Mihatsch M, Fisker N, et al. From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides. Toxicol Sci. 2017;157:112-128 pubmed 出版商
Xilouri M, Brekk O, Polissidis A, Chrysanthou Piterou M, Kloukina I, Stefanis L. Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats. Autophagy. 2016;12:2230-2247 pubmed
Mitchell S, Madrigal Matute J, Scheibye Knudsen M, Fang E, Aon M, González Reyes J, et al. Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab. 2016;23:1093-1112 pubmed 出版商
Kaushik S, Cuervo A. AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA. Autophagy. 2016;12:432-8 pubmed 出版商
Mareninova O, Sendler M, Malla S, Yakubov I, French S, Tokhtaeva E, et al. Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis. Cell Mol Gastroenterol Hepatol. 2015;1:678-694 pubmed
Kaushik S, Cuervo A. Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis. Nat Cell Biol. 2015;17:759-70 pubmed 出版商
Park Y, Liu C, Luo T, Dietrich W, Bramlett H, Hu B. Chaperone-Mediated Autophagy after Traumatic Brain Injury. J Neurotrauma. 2015;32:1449-57 pubmed 出版商
Kett L, Stiller B, Bernath M, Tasset I, Blesa J, Jackson Lewis V, et al. α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2. J Neurosci. 2015;35:5724-42 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
LAMP-2A多克隆抗体(AMC2)
目录# :
51-2200
规格 :
100微克
价格 :
375美元
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
小鼠, 大鼠
应用 :
ELISA: 0.1-1 µg/mL, Inhibition Assays: Assay Dependent, Western Blot: 0.1-1 µg/mL
物种 :
小鼠, 大鼠
克隆 :
AMC2
抗体亚型 :
IgG
储存 :
-20°C
描述 :
LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome. Prior to posttranslational modification, LAMP2 is approximately 46 kDa polypeptide. Mature, functional LAMP2 is extensively glycosylated with a variety of different N-linked and O-linked oligosaccharides with a total molecular weight of about 100-130 kDa. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. LAMP2 is used to monitor a very selective form of autophagy called chaperone-mediated autophagy. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. The LAMP protein has 3 variant forms: LAMP-2A, -2B, and 2C. LAMP2, together with CD107a/LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, and LAMP2 is an important regulator in successful phagosomal maturation. LAMP2 deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danon’s disease).
免疫原 :
A synthetic peptide of the cytosolic tail of rat LAMP-2A (GLKRHHTGYEQF)
格式 :
液体
应用w/稀释 :
ELISA: 0.1-1 µg/mL, Inhibition Assays: Assay Dependent, Western Blot: 0.1-1 µg/mL
别名 :
CD107 antigen-like family member B; CD107b; EGK_20887; Igp96; Lamp II; LAMP2; Lamp-2; LAMP-2 Isoform 2A; LAMP-2 Variant A; Lamp-2a; Lamp-2b; Lamp-2c; LAMPB; LGP110; LGP-110; LGP-96; LGP-B; lysosomal associated membrane protein 2; lysosomal membrane glycoprotein 2; lysosomal membrane glycoprotein type B; lysosomal-associated membrane protein 2; lysosome-associated membrane glycoprotein 2; lysosome-associated membrane protein 2; Mac3; RP23-193O17.2
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国