产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
乙淀粉样蛋白多克隆抗体(CT695)
目录 :
51-2700
规格 :
50微克
价格 :
美国375.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
CT695
反应物种 :
longfin inshore squid, 人类, 小鼠, 大鼠, pigs
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-冰冻切片, 免疫组化-自由浮动切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 35
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; pigs ; 1:250; 图 1a
Kallakuri S, Desai A, Feng K, Tummala S, Saif T, Chen C, et al. Neuronal Injury and Glial Changes Are Hallmarks of Open Field Blast Exposure in Swine Frontal Lobe. PLoS ONE. 2017;12:e0169239 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 图 2e
Hübner N, Mechling A, Lee H, Reisert M, Bienert T, Hennig J, et al. The connectomics of brain demyelination: Functional and structural patterns in the cuprizone mouse model. Neuroimage. 2017;146:1-18 pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Tapia Rojas C, Burgos P, Inestrosa N. Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-? (A?)42 peptides. J Neurochem. 2016;139:1175-1191 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3a
Qin X, Wang Y, Paudel H. Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of ?-Secretase 1 (BACE-1) in the Brain. J Biol Chem. 2016;291:22276-22287 pubmed
  • 免疫细胞化学; longfin inshore squid; 图 1
Stevenson J, Conaty E, Walsh R, Poidomani P, Samoriski C, Scollins B, et al. The Amyloid Precursor Protein of Alzheimer's Disease Clusters at the Organelle/Microtubule Interface on Organelles that Bind Microtubules in an ATP Dependent Manner. PLoS ONE. 2016;11:e0147808 pubmed 出版商
Bradshaw D, Knutsen A, Korotcov A, Sullivan G, Radomski K, Dardzinski B, et al. Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures. Acta Neuropathol Commun. 2021;9:89 pubmed 出版商
Cai C, Yang C, Zhuang X, Yuan N, Wu M, Tan J, et al. NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation. Autophagy. 2020;:1-19 pubmed 出版商
Losurdo M, Davidsson J, Sköld M. Diffuse Axonal Injury in the Rat Brain: Axonal Injury and Oligodendrocyte Activity Following Rotational Injury. Brain Sci. 2020;10: pubmed 出版商
Song J, Malampati S, Zeng Y, Durairajan S, Yang C, Tong B, et al. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. Aging Cell. 2019;:e13069 pubmed 出版商
d Uscio L, Katusic Z. Vascular phenotype of amyloid precursor protein-deficient mice. Am J Physiol Heart Circ Physiol. 2019;316:H1297-H1308 pubmed 出版商
Anthony Jalin A, Jin R, Wang M, Li G. EPPS treatment attenuates traumatic brain injury in mice by reducing Aβ burden and ameliorating neuronal autophagic flux. Exp Neurol. 2019;314:20-33 pubmed 出版商
Chierto E, Simon A, Castoldi F, Meffre D, Cristinziano G, Sapone F, et al. Mechanical Stretch of High Magnitude Provokes Axonal Injury, Elongation of Paranodal Junctions, and Signaling Alterations in Oligodendrocytes. Mol Neurobiol. 2019;56:4231-4248 pubmed 出版商
Gorse K, Lafrenaye A. The Importance of Inter-Species Variation in Traumatic Brain Injury-Induced Alterations of Microglial-Axonal Interactions. Front Neurol. 2018;9:778 pubmed 出版商
McDonald W, Jones E, Wojciak J, Drake R, Sabbadini R, Harris N. Matrix-Assisted Laser Desorption Ionization Mapping of Lysophosphatidic Acid Changes after Traumatic Brain Injury and the Relationship to Cellular Pathology. Am J Pathol. 2018;188:1779-1793 pubmed 出版商
Kawa L, Kamnaksh A, Long J, Arborelius U, Hokfelt T, Agoston D, et al. A Comparative Study of Two Blast-Induced Traumatic Brain Injury Models: Changes in Monoamine and Galanin Systems Following Single and Repeated Exposure. Front Neurol. 2018;9:479 pubmed 出版商
Lyons D, Vekaria H, Macheda T, Bakshi V, Powell D, Gold B, et al. A mild traumatic brain injury in mice produces lasting deficits in brain metabolism. J Neurotrauma. 2018;: pubmed 出版商
Sauerbeck A, Fanizzi C, Kim J, Gangolli M, Bayly P, Wellington C, et al. modCHIMERA: a novel murine closed-head model of moderate traumatic brain injury. Sci Rep. 2018;8:7677 pubmed 出版商
Ziogas N, Koliatsos V. Primary Traumatic Axonopathy in Mice Subjected to Impact Acceleration: A Reappraisal of Pathology and Mechanisms with High-Resolution Anatomical Methods. J Neurosci. 2018;38:4031-4047 pubmed 出版商
Young J, Fong L, Frankowski H, Petsko G, Small S, Goldstein L. Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein. Stem Cell Reports. 2018;10:1046-1058 pubmed 出版商
Vascak M, Jin X, Jacobs K, Povlishock J. Mild Traumatic Brain Injury Induces Structural and Functional Disconnection of Local Neocortical Inhibitory Networks via Parvalbumin Interneuron Diffuse Axonal Injury. Cereb Cortex. 2018;28:1625-1644 pubmed 出版商
Tapia Rojas C, Inestrosa N. Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20-APP transgenic and wild-type mice. J Neurochem. 2017;: pubmed 出版商
Yang C, Cai C, Song J, Tan J, Durairajan S, Iyaswamy A, et al. NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models. Autophagy. 2017;13:2028-2040 pubmed 出版商
Haber M, Hutchinson E, Sadeghi N, Cheng W, Namjoshi D, Cripton P, et al. Defining an Analytic Framework to Evaluate Quantitative MRI Markers of Traumatic Axonal Injury: Preliminary Results in a Mouse Closed Head Injury Model. Eneuro. 2017;4: pubmed 出版商
Kallakuri S, Purkait H, Dalavayi S, VandeVord P, Cavanaugh J. Blast overpressure induced axonal injury changes in rat brainstem and spinal cord. J Neurosci Rural Pract. 2015;6:481-7 pubmed 出版商
Gyoneva S, Kim D, Katsumoto A, Kokiko Cochran O, Lamb B, Ransohoff R. Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury. J Neuroinflammation. 2015;12:228 pubmed 出版商
Quigley H, Pitha I, Welsbie D, Nguyen C, Steinhart M, Nguyen T, et al. Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma. PLoS ONE. 2015;10:e0141137 pubmed 出版商
Lafrenaye A, Todani M, Walker S, Povlishock J. Microglia processes associate with diffusely injured axons following mild traumatic brain injury in the micro pig. J Neuroinflammation. 2015;12:186 pubmed 出版商
Rolyan H, Tyurina Y, Hernandez M, Amoscato A, Sparvero L, Nmezi B, et al. Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression. J Neurosci. 2015;35:12002-17 pubmed 出版商
Cavieres V, González A, Muñoz V, Yefi C, Bustamante H, Barraza R, et al. Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy. PLoS ONE. 2015;10:e0136313 pubmed 出版商
Del Mar N, von Buttlar X, Yu A, Guley N, Reiner A, Honig M. A novel closed-body model of spinal cord injury caused by high-pressure air blasts produces extensive axonal injury and motor impairments. Exp Neurol. 2015;271:53-71 pubmed 出版商
Bennett R, Brody D. Array tomography for the detection of non-dilated, injured axons in traumatic brain injury. J Neurosci Methods. 2015;245:25-36 pubmed 出版商
Cantoni C, Bollman B, Licastro D, Xie M, Mikesell R, Schmidt R, et al. TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta Neuropathol. 2015;129:429-47 pubmed 出版商
HÃ¥nell A, Greer J, McGinn M, Povlishock J. Traumatic brain injury-induced axonal phenotypes react differently to treatment. Acta Neuropathol. 2015;129:317-32 pubmed 出版商
Kawa L, Arborelius U, Yoshitake T, Kehr J, Hökfelt T, Risling M, et al. Neurotransmitter Systems in a Mild Blast Traumatic Brain Injury Model: Catecholamines and Serotonin. J Neurotrauma. 2015;32:1190-9 pubmed 出版商
Yan Y, Eipper B, Mains R. Kalirin-9 and Kalirin-12 Play Essential Roles in Dendritic Outgrowth and Branching. Cereb Cortex. 2015;25:3487-501 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
乙淀粉样蛋白多克隆抗体(CT695)
目录# :
51-2700
规格 :
50微克
价格 :
美国375.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
人类, 小鼠, 猪, 大鼠
应用 :
ELISA: 0.1-1.0 µg/mL, Immunohistochemistry: 0.1-1.0 µg/mL, Western Blot: 0.2-2 µg/mL
物种 :
人类, 小鼠, 猪, 大鼠
克隆 :
CT695
抗体亚型 :
IgG
储存 :
-20°C
描述 :
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer's disease. Abeta peptide is 40-43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease, beta-secretase (BACE) which is synthesized as a propeptide and must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP, and a membrane-bound remnant. The remnant protein is processed by another protease, gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. The transmembrane glycoprotein, nicastrin, is associated with presinilins and has been found to bind to the carboxyl-terminus of beta APP and helps to modulate the production of the amyloid beta peptide. Abeta is an extracellular filamentous protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles. Alzheimer’s disease, the most common cause of senile dementia, is characterized by abnormal filamentous protein deposits in the brain. Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type), cerebroarterial amyloidosis (cerebral amyloid angiopathy) and in the Guam Parkinson-Dementia complex.
免疫原 :
A 22 amino acid synthetic peptide derived from the C-terminus of the human beta-amyloid precursor protein (beta-APP). This sequence is 100% conserved in human, monkey, mouse, rat, guinea pig, and chicken beta-APP proteins.
格式 :
液体
应用w/稀释 :
ELISA: 0.1-1.0 µg/mL, Immunohistochemistry: 0.1-1.0 µg/mL, Western Blot: 0.2-2 µg/mL
别名 :
A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; Amyloid; amyloid A4; Amyloid b; Amyloid beta; amyloid beta (A4) precursor protein; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; amyloid precursor protein variant 1; amyloid precursor protein variant 2; Amyloid ß; amyloid-beta A4 protein; amyloid-beta A4 protein; amyloid beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta amyloid protein; beta amyloid protein precursor; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); Beta-amyloid precursor protein; betaApp; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTF gamma; CTF-alpha; CTFgamma; CVAP; E030013M08Rik; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; OTTHUMP00000096096; P3(40); P3(42); Pan-Abeta; peptidase nexin-II; PN2; PN-II; PreA4; PreA4 751; protease nexin II; protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国