产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
ALK多克隆抗体
目录 :
51-3900
规格 :
100微克
价格 :
425美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 3
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 1
Lee J, Li C, Huang H, Zhu M, Mariño Enríquez A, Lee C, et al. ALK oncoproteins in atypical inflammatory myofibroblastic tumours: novel RRBP1-ALK fusions in epithelioid inflammatory myofibroblastic sarcoma. J Pathol. 2017;241:316-323 pubmed 出版商
Seashore Ludlow B, Rees M, Cheah J, Cokol M, Price E, Coletti M, et al. Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset. Cancer Discov. 2015;5:1210-23 pubmed 出版商
He D, Chen H, Muramatsu H, Lasek A. Ethanol activates midkine and anaplastic lymphoma kinase signaling in neuroblastoma cells and in the brain. J Neurochem. 2015;135:508-21 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
ALK多克隆抗体
目录# :
51-3900
规格 :
100微克
价格 :
425美元
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
人类
应用 :
ELISA: 0.1-1.0 µg/mL, Immunofluorescence: Assay Dependent, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1-5 µg/mL
物种 :
人类
抗体亚型 :
IgG
储存 :
-20°C
描述 :
The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
免疫原 :
A recombinant protein derived from amino acids 1359-1466 of the 1620 amino acid human ALK protein which corresponds to amino acids 426-528 of the 680 NPM-ALK chimeric protein.
格式 :
液体
应用w/稀释 :
ELISA: 0.1-1.0 µg/mL, Immunofluorescence: Assay Dependent, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1-5 µg/mL
别名 :
Alk; ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; EC 2.7.10.1; kinase ALK; mutant anaplastic lymphoma kinase; NBLST3; npm-alk; p80; Tcrz; TFG/ALK
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国