公司名称 :
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
产品名称 :
目录 :
规格 :
价格 :
克隆性 :
宿主 :
domestic rabbit
共轭标签 :
反应物种 :
Mongolian jird, 人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-冰冻切片, 免疫组化-自由浮动切片
更多信息或购买 :
文章摘录数: 45
  • 免疫组化; 小鼠
Wani A, Zhu J, ULRICH J, Eteleeb A, Sauerbeck A, Reitz S, et al. Neuronal VCP loss of function recapitulates FTLD-TDP pathology. Cell Rep. 2021;36:109399 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 4d
Rosa J, Farré Alins V, Ortega M, Navarrete M, López Rodríguez A, Palomino Antolin A, et al. TLR4 pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury. Br J Pharmacol. 2021;178:3395-3413 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2b
Zhong X, Harris G, Smirnova L, Zufferey V, Sá R, Baldino Russo F, et al. Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model. Front Cell Neurosci. 2020;14:25 pubmed 出版商
  • 免疫细胞化学; 人类; 图 3b
Cifelli J, Berg K, Yang J. Benzothiazole amphiphiles promote RasGRF1-associated dendritic spine formation in human stem cell-derived neurons. FEBS Open Bio. 2020;10:386-395 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 1:350; 图 3c
Velasco S, Kedaigle A, Simmons S, Nash A, Rocha M, Quadrato G, et al. Individual brain organoids reproducibly form cell diversity of the human cerebral cortex. Nature. 2019;: pubmed 出版商
  • 免疫组化; 小鼠; 1:250; 图 1d
Salazar S, Cox T, Lee S, Brody A, Chyung A, Haas L, et al. Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss. J Neurosci. 2019;39:758-772 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 1f
Norris G, Smirnov I, Filiano A, Shadowen H, Cody K, Thompson J, et al. Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury. J Exp Med. 2018;215:1789-1801 pubmed 出版商
  • 免疫组化; 小鼠; 1:300; 图 s8a
Vainchtein I, Chin G, Cho F, Kelley K, Miller J, Chien E, et al. Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science. 2018;359:1269-1273 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 3c
Nakao A, Miyazaki N, Ohira K, Hagihara H, Takagi T, Usuda N, et al. Immature morphological properties in subcellular-scale structures in the dentate gyrus of Schnurri-2 knockout mice: a model for schizophrenia and intellectual disability. Mol Brain. 2017;10:60 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:250; 图 5c
Salazar S, Gallardo C, Kaufman A, Herber C, Haas L, Robinson S, et al. Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease. J Neurosci. 2017;37:9207-9221 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 1a
Dwyer C, Scudder S, Lin Y, Dozier L, Phan D, Allen N, et al. Neurodevelopmental Changes in Excitatory Synaptic Structure and Function in the Cerebral Cortex of Sanfilippo Syndrome IIIA Mice. Sci Rep. 2017;7:46576 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s1a
Zhang Q, Esrafilzadeh D, Crook J, Kapsa R, Stewart E, Tomaskovic Crook E, et al. Electrical Stimulation Using Conductive Polymer Polypyrrole Counters Reduced Neurite Outgrowth of Primary Prefrontal Cortical Neurons from NRG1-KO and DISC1-LI Mice. Sci Rep. 2017;7:42525 pubmed 出版商
  • 免疫组化; 小鼠; 1:200; 图 6c
Takahashi H, Klein Z, Bhagat S, Kaufman A, Kostylev M, Ikezu T, et al. Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathol. 2017;133:785-807 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4d
Nguyen T, Schreiner D, Xiao L, Traunmüller L, Bornmann C, Scheiffele P. An alternative splicing switch shapes neurexin repertoires in principal neurons versus interneurons in the mouse hippocampus. elife. 2016;5: pubmed 出版商
  • 免疫组化; 小鼠; 1:1000; 图 2
Breton Provencher V, Bakhshetyan K, Hardy D, Bammann R, Cavarretta F, Snapyan M, et al. Principal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb. Nat Commun. 2016;7:12659 pubmed 出版商
  • 免疫组化; Mongolian jird; 1:200; 图 1
Zhang T, Huang L, Zhang L, Tan M, Pu M, Pickard G, et al. ON and OFF retinal ganglion cells differentially regulate serotonergic and GABAergic activity in the dorsal raphe nucleus. Sci Rep. 2016;6:26060 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:500; 图 1
Kim S, Hayashi H, Ishikawa T, Shibata K, Shigetomi E, Shinozaki Y, et al. Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain. J Clin Invest. 2016;126:1983-97 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 1
Williams P, Tribble J, Pepper K, Cross S, Morgan B, Morgan J, et al. Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma. Mol Neurodegener. 2016;11:26 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 1:200; 图 6
Sekar A, Bialas A, de Rivera H, Davis A, Hammond T, Kamitaki N, et al. Schizophrenia risk from complex variation of complement component 4. Nature. 2016;530:177-83 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:200; 图 6
Jara J, Stanford M, Zhu Y, Tu M, Hauswirth W, Bohn M, et al. Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex. Gene Ther. 2016;23:272-82 pubmed 出版商
  • 免疫组化; 小鼠; 1:250; 图 s10
Haas L, Salazar S, Kostylev M, Um J, Kaufman A, Strittmatter S. Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease. Brain. 2016;139:526-46 pubmed 出版商
Yang N, Zhang Y, Wang J, Chen C, Song Y, Liang J, et al. Effects of Dexamethasone on Remodeling of the Hippocampal Synaptic Filamentous Actin Cytoskeleton in a Model of Pilocarpine-induced Status Epilepticus. Int J Med Sci. 2020;17:1683-1691 pubmed 出版商
Sathyamurthy A, Barik A, Dobrott C, Matson K, Stoica S, Pursley R, et al. Cerebellospinal Neurons Regulate Motor Performance and Motor Learning. Cell Rep. 2020;31:107595 pubmed 出版商
Gomez Giro G, Arias Fuenzalida J, Jarazo J, Zeuschner D, Ali M, Possemis N, et al. Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis. Acta Neuropathol Commun. 2019;7:222 pubmed 出版商
Gao X, Grendel J, Muhia M, Castro Gomez S, Süsens U, Isbrandt D, et al. Disturbed prefrontal cortex activity in the absence of schizophrenia-like behavioral dysfunction in Arc/Arg3.1 deficient mice. J Neurosci. 2019;: pubmed 出版商
Zhou B, Chen L, Liao P, Huang L, Chen Z, Liao D, et al. Astroglial dysfunctions drive aberrant synaptogenesis and social behavioral deficits in mice with neonatal exposure to lengthy general anesthesia. PLoS Biol. 2019;17:e3000086 pubmed 出版商
Xu R, Brawner A, Li S, Liu J, Kim H, Xue H, et al. OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome. Cell Stem Cell. 2019;: pubmed 出版商
Huang C, Muszynski K, Bolshakov V, Balu D. Deletion of Dtnbp1 in mice impairs threat memory consolidation and is associated with enhanced inhibitory drive in the amygdala. Transl Psychiatry. 2019;9:132 pubmed 出版商
Zhang W, Yang B, Weng H, Liu T, Shi L, Yu P, et al. Wheel Running Improves Motor Function and Spinal Cord Plasticity in Mice With Genetic Absence of the Corticospinal Tract. Front Cell Neurosci. 2019;13:106 pubmed 出版商
Cox T, Gunther E, Brody A, Chiasseu M, Stoner A, Smith L, et al. Anti-PrPC antibody rescues cognition and synapses in transgenic alzheimer mice. Ann Clin Transl Neurol. 2019;6:554-574 pubmed 出版商
Gunther E, Smith L, Kostylev M, Cox T, Kaufman A, Lee S, et al. Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists. Cell Rep. 2019;26:145-158.e8 pubmed 出版商
Dhar M, Hantman A, Nishiyama H. Developmental pattern and structural factors of dendritic survival in cerebellar granule cells in vivo. Sci Rep. 2018;8:17561 pubmed 出版商
Dell Anno M, Wang X, Onorati M, Li M, Talpo F, Sekine Y, et al. Human neuroepithelial stem cell regional specificity enables spinal cord repair through a relay circuit. Nat Commun. 2018;9:3419 pubmed 出版商
Risher W, Kim N, Koh S, Choi J, Mitev P, Spence E, et al. Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1. J Cell Biol. 2018;217:3747-3765 pubmed 出版商
He H, Shen W, Zheng L, Guo X, Cline H. Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity. Nat Commun. 2018;9:2893 pubmed 出版商
Helleringer R, Le Verger D, Li X, Izabelle C, Chaussenot R, Belmaati Cherkaoui M, et al. Cerebellar synapse properties and cerebellum-dependent motor and non-motor performance in Dp71-null mice. Dis Model Mech. 2018;11: pubmed 出版商
Koh S, Chen W, Dejneka N, Harris I, Lu B, Girman S, et al. Subretinal Human Umbilical Tissue-Derived Cell Transplantation Preserves Retinal Synaptic Connectivity and Attenuates Müller Glial Reactivity. J Neurosci. 2018;38:2923-2943 pubmed 出版商
Smith L, Zhu R, Strittmatter S. Disease-modifying benefit of Fyn blockade persists after washout in mouse Alzheimer's model. Neuropharmacology. 2018;130:54-61 pubmed 出版商
Farhy Tselnicker I, van Casteren A, Lee A, Chang V, Aricescu A, Allen N. Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation. Neuron. 2017;96:428-445.e13 pubmed 出版商
Singh S, Stogsdill J, Pulimood N, Dingsdale H, Kim Y, Pilaz L, et al. Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. Cell. 2016;164:183-196 pubmed 出版商
Kim E, Woo M, Qin L, Ma T, Beltran C, Bao Y, et al. Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke. J Neurosci. 2015;35:15113-26 pubmed 出版商
Nygaard H, Kaufman A, Sekine Konno T, Huh L, Going H, Feldman S, et al. Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model. Alzheimers Res Ther. 2015;7:25 pubmed 出版商
Risher M, Fleming R, Risher W, Miller K, Klein R, WILLS T, et al. Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood. Alcohol Clin Exp Res. 2015;39:989-97 pubmed 出版商
Goyer D, Fensky L, Hilverling A, Kurth S, Kuenzel T. Expression of the postsynaptic scaffold PSD-95 and development of synaptic physiology during giant terminal formation in the auditory brainstem of the chicken. Eur J Neurosci. 2015;41:1416-29 pubmed 出版商
Kaufman A, Salazar S, Haas L, Yang J, Kostylev M, Jeng A, et al. Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann Neurol. 2015;77:953-71 pubmed 出版商
产品类型 :
产品名称 :
目录# :
规格 :
价格 :
克隆性 :
纯度 :
宿主 :
反应物种 :
人类, 小鼠, 大鼠
应用 :
ELISA: 0.1-1.0 µg/mL, Immunocytochemistry: 1:200, Immunoprecipitation: 5 µg, Western Blot: 1.0 µg/mL
物种 :
人类, 小鼠, 大鼠
抗体亚型 :
储存 :
描述 :
Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors, Shaker-type potassium channels at the synaptic membrane in central nervous system (CNS) neurons. There are two principal modes of interaction between PSD-95 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits), and some of these proteins may interact with PSD-95 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-95 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
免疫原 :
KLH-conjugated synthethic peptide derived from the C-terminal region of human PSD-95.
格式 :
应用w/稀释 :
ELISA: 0.1-1.0 µg/mL, Immunocytochemistry: 1:200, Immunoprecipitation: 5 µg, Western Blot: 1.0 µg/mL
别名 :
discs large homolog 4; discs large MAGUK scaffold protein 4; discs, large homolog 4; discs, large homolog 4 (Drosophila); disks large homolog 4; Dlg4; Dlgh4; FLJ97752; FLJ98574; post synaptic density; postsynaptic density protein 95; post-synaptic density protein 95; PSD95; PSD-95; PSD-95 alpha 2b; PSD-95 beta; Sap90; SAP-90; SAP90A; Synapse-associated protein 90; synapse-associated protein SAP90; Tax interaction protein 15
更多信息或购买 :
公司总部: 美国