产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
雌激素受体β多克隆抗体
目录 :
51-7700
规格 :
100微克
价格 :
美国398.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 牛
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 6
出版应用/物种/样本/稀释参考文献
  • 免疫沉淀; 小鼠; 图 3b
Yuan B, Yang J, Dubeau L, Hu Y, Li R. A Phosphotyrosine Switch in Estrogen Receptor β Is Required for Mouse Ovarian Function. Front Cell Dev Biol. 2021;9:649087 pubmed 出版商
  • 流式细胞仪; 牛; 1:50; 图 6
Medina Estrada I, López Meza J, Ochoa Zarzosa A. Anti-Inflammatory and Antimicrobial Effects of Estradiol in Bovine Mammary Epithelial Cells during Staphylococcus aureus Internalization. Mediators Inflamm. 2016;2016:6120509 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 1
  • 免疫印迹; 小鼠; 图 1
Pedram A, Razandi M, Blumberg B, Levin E. Membrane and nuclear estrogen receptor α collaborate to suppress adipogenesis but not triglyceride content. FASEB J. 2016;30:230-40 pubmed 出版商
Bado I, Pham E, Soibam B, Nikolos F, Gustafsson J, Thomas C. ERβ alters the chemosensitivity of luminal breast cancer cells by regulating p53 function. Oncotarget. 2018;9:22509-22522 pubmed 出版商
Novaira H, Graceli J, Capellino S, Schoeffield A, Hoffman G, Wolfe A, et al. Development and Characterization of Novel Rat Anti-mER? Sera. Endocrinology. 2016;157:2844-52 pubmed 出版商
Bean L, Kumar A, Rani A, Guidi M, Rosario A, Cruz P, et al. Re-Opening the Critical Window for Estrogen Therapy. J Neurosci. 2015;35:16077-93 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
雌激素受体β多克隆抗体
目录# :
51-7700
规格 :
100微克
价格 :
美国398.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
人类
应用 :
ELISA: 1.0 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 1-2 µg/mL
物种 :
人类
抗体亚型 :
IgG
储存 :
-20°C
描述 :
Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.
免疫原 :
A 19 amino acid synthetic peptide derived from the C-terminus of the human Estrogen Receptor-beta protein.
格式 :
液体
应用w/稀释 :
ELISA: 1.0 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 1-2 µg/mL
别名 :
ER; ER beta; ER[b]; Erb; Erb2; Erbeta; ER-beta; Esr2; ESRB; ESR-BETA; ESTRB; estrogen receptor 2; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; estrogen receptor beta; estrogen receptor beta 1 isoform deletion variant; estrogen receptor beta 4; NR3A2; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta; steroid receptor
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国