产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
雌激素受体β多克隆抗体
目录 :
51-7700
规格 :
100µg
价格 :
331美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, , 猕猴
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 17
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 牛; 1:50; 图 6
Medina Estrada I, López Meza J, Ochoa Zarzosa A. Anti-Inflammatory and Antimicrobial Effects of Estradiol in Bovine Mammary Epithelial Cells during Staphylococcus aureus Internalization. Mediators Inflamm. 2016;2016:6120509 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 1
  • 免疫印迹; 小鼠; 图 1
Pedram A, Razandi M, Blumberg B, Levin E. Membrane and nuclear estrogen receptor α collaborate to suppress adipogenesis but not triglyceride content. FASEB J. 2016;30:230-40 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 9
  • 免疫印迹; 大鼠; 1:500; 图 9
Bean L, Kumar A, Rani A, Guidi M, Rosario A, Cruz P, et al. Re-Opening the Critical Window for Estrogen Therapy. J Neurosci. 2015;35:16077-93 pubmed 出版商
  • 免疫印迹; 人类
Razandi M, Pedram A, Jordan V, Fuqua S, Levin E. Tamoxifen regulates cell fate through mitochondrial estrogen receptor beta in breast cancer. Oncogene. 2013;32:3274-85 pubmed 出版商
  • 免疫组化; 人类; 1:250; 图 1
Munchrath L, Hofmann H. Distribution of sex steroid hormone receptors in the brain of an African cichlid fish, Astatotilapia burtoni. J Comp Neurol. 2010;518:3302-26 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 4
Meireles S, Esteves G, Hirata R, Peri S, Devarajan K, Slifker M, et al. Early changes in gene expression induced by tobacco smoke: Evidence for the importance of estrogen within lung tissue. Cancer Prev Res (Phila). 2010;3:707-17 pubmed 出版商
  • 免疫印迹; 猕猴; 图 7
  • 免疫印迹; 大鼠; 1:100
  • 免疫印迹; 小鼠
  • 免疫印迹; 人类; 1:100; 图 7
Fu X, Zhu B. Human pancreas-specific protein disulfide isomerase homolog (PDIp) is an intracellular estrogen-binding protein that modulates estrogen levels and actions in target cells. J Steroid Biochem Mol Biol. 2009;115:20-9 pubmed 出版商
Bado I, Pham E, Soibam B, Nikolos F, Gustafsson J, Thomas C. ERβ alters the chemosensitivity of luminal breast cancer cells by regulating p53 function. Oncotarget. 2018;9:22509-22522 pubmed 出版商
Novaira H, Graceli J, Capellino S, Schoeffield A, Hoffman G, Wolfe A, et al. Development and Characterization of Novel Rat Anti-mER? Sera. Endocrinology. 2016;157:2844-52 pubmed 出版商
Snyder M, Smejkalova T, Forlano P, Woolley C. Multiple ERbeta antisera label in ERbeta knockout and null mouse tissues. J Neurosci Methods. 2010;188:226-34 pubmed 出版商
Sassi F, Benazzi C, Castellani G, Sarli G. Molecular-based tumour subtypes of canine mammary carcinomas assessed by immunohistochemistry. BMC Vet Res. 2010;6:5 pubmed 出版商
Pedram A, Razandi M, Sainson R, Kim J, Hughes C, Levin E. A conserved mechanism for steroid receptor translocation to the plasma membrane. J Biol Chem. 2007;282:22278-88 pubmed
Mhyre A, Shapiro R, Dorsa D. Estradiol reduces nonclassical transcription at cyclic adenosine 3',5'-monophosphate response elements in glioma cells expressing estrogen receptor alpha. Endocrinology. 2006;147:1796-804 pubmed
Mhyre A, Dorsa D. Estrogen activates rapid signaling in the brain: role of estrogen receptor alpha and estrogen receptor beta in neurons and glia. Neuroscience. 2006;138:851-8 pubmed
Kanda N, Watanabe S. 17beta-estradiol enhances heparin-binding epidermal growth factor-like growth factor production in human keratinocytes. Am J Physiol Cell Physiol. 2005;288:C813-23 pubmed
Razandi M, Pedram A, Merchenthaler I, Greene G, Levin E. Plasma membrane estrogen receptors exist and functions as dimers. Mol Endocrinol. 2004;18:2854-65 pubmed
Skliris G, Parkes A, Limer J, Burdall S, Carder P, Speirs V. Evaluation of seven oestrogen receptor beta antibodies for immunohistochemistry, western blotting, and flow cytometry in human breast tissue. J Pathol. 2002;197:155-62 pubmed
产品信息
产品类型 :
抗体
产品名称 :
雌激素受体β多克隆抗体
目录# :
51-7700
规格 :
100µg
价格 :
331美元
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
反应物种 :
人类
应用 :
ELISA: 1.0 µg/mL, Immunohistochemistry (Frozen): Assay Dependent, Western Blot: 1-2 µg/mL
物种 :
人类
抗体亚型 :
IgG
储存 :
-20°C
描述 :
Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.
免疫原 :
A 19 amino acid synthetic peptide derived from the C-terminus of the human Estrogen Receptor-beta protein.
格式 :
液体
应用w/稀释 :
ELISA: 1.0 µg/mL, Immunohistochemistry (Frozen): Assay Dependent, Western Blot: 1-2 µg/mL
别名 :
Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2, ESR2, ESTRB, NR3A2
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国