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抗体

CD200R3 Monoclonal Antibody (Ba13), Alexa Fluor 488, eBioscience™

53-2001-80

25微克

美国139.00

单克隆

大鼠

AF488

Ba13

CD200R3 Monoclonal Antibody (Ba13), Alexa Fluor 488, eBioscience™

53-2001-80

25微克

美国139.00

单克隆

亲和色谱

大鼠

小鼠

Flow Cytometry: 0.25 µg/test

小鼠

Ba13

IgG2a, kappa

4° C, store in dark, DO NOT FREEZE!

CD200R3 is a dimeric cell surface receptor also known as CD200RLb. CD200R3 contains two Ig-like extracellular domains and as such is a member of the immunoglobulin superfamily of receptors. The intracellular region of CD200R3 associates with the adaptor molecule DAP12, and possibly also DAP10, CD3 zeta and FcR gamma-chain, indicating that it is capable of transducing stimulatory signals. In this respect CD200R3 bears similarity to activatory receptors CD200R2 and CD200R4. In contrast, an inhibitory receptor CD200R (also known as CD200R1) relies on other adaptors. CD200R3 is primarily expressed by basophils and mast cells, cells known to be involved in anti-parasitic immune responses and frequently also allergic reactions. The surface expression of CD200R3 decreases when basophils are activated by ligating their CD16 and CD32. Remarkably, most of this downregulation is observed within the first 30 minutes after activation. Unlike CD200R, CD200R3 does not bind CD200.

Mouse primary basophils

液体

Flow Cytometry: 0.25 µg/test

4733401I18Rik; 4833409J19Rik; AI505817; BB106877; CD200 cell surface glycoprotein receptor 3; CD200 cell surface glycoprotein receptor-like 3; CD200 cell surface glycoprotein receptor-like b; CD200 receptor 3; CD200 receptor-like 3; Cd200r3; CD200RLb; cell surface glycoprotein CD200 receptor 3; Cell surface glycoprotein OX2 receptor 3; mCD200RLb