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抗体

IRF8 Monoclonal Antibody (V3GYWCH), Alexa Fluor™ 488, eBioscience

53-9852-80

25微克

美国135.00

单克隆

小鼠

AF488

V3GYWCH

人类, 小鼠

IRF8 Monoclonal Antibody (V3GYWCH), Alexa Fluor™ 488, eBioscience

53-9852-80

25微克

美国135.00

单克隆

亲和色谱

小鼠

人类, 小鼠

Flow Cytometry: 0.25 µg/test

人类, 小鼠

V3GYWCH

IgG1, kappa

4° C, store in dark, DO NOT FREEZE!

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.

液体

Flow Cytometry: 0.25 µg/test

AI893568; H-ICSBP; Icsbp; Icsbp1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; Irf8; IRF-8; Myls; transcription factor ICSBP