产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD284 (TLR4) Monoclonal Antibody (HTA125), Alexa Fluor™ 488, eBioscience
目录 :
53-9917-41
规格 :
25试验
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
AF488
克隆名称 :
HTA125
反应物种 :
人类
应用 :
流式细胞仪
更多信息或购买 :
文章摘录数: 239
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 5
Lindsay S, Johnstone S, McGrath M, Mallinson D, Barnett S. Comparative miRNA-Based Fingerprinting Reveals Biological Differences in Human Olfactory Mucosa- and Bone-Marrow-Derived Mesenchymal Stromal Cells. Stem Cell Reports. 2016;6:729-742 pubmed 出版商
Roth C, Craveiro R, Niederau C, Malyaran H, Neuss S, Jankowski J, et al. Mechanical Compression by Simulating Orthodontic Tooth Movement in an In Vitro Model Modulates Phosphorylation of AKT and MAPKs via TLR4 in Human Periodontal Ligament Cells. Int J Mol Sci. 2022;23: pubmed 出版商
Yang Y, Hu Y, Zhou Y, Liang T, Tang H, Ju H, et al. Lys694Arg polymorphism leads to blunted responses to LPS by interfering TLR4 with recruitment of MyD88. Innate Immun. 2020;:1753425920927479 pubmed 出版商
Quirino Teixeira A, Rozini S, Barbosa Lima G, Coelho D, Carneiro P, Mohana Borges R, et al. Inflammatory signaling in dengue-infected platelets requires translation and secretion of nonstructural protein 1. Blood Adv. 2020;4:2018-2031 pubmed 出版商
Suzuki K, Ohkuma M, Nagaoka I. Bacterial lipopolysaccharide and antimicrobial LL-37 enhance ICAM-1 expression and NF-κB p65 phosphorylation in senescent endothelial cells. Int J Mol Med. 2019;44:1187-1196 pubmed 出版商
Faraj T, Stover C, Erridge C. Dietary Toll-Like Receptor Stimulants Promote Hepatic Inflammation and Impair Reverse Cholesterol Transport in Mice via Macrophage-Dependent Interleukin-1 Production. Front Immunol. 2019;10:1404 pubmed 出版商
Xiao T, Wu S, Yan C, Zhao C, Jin H, Yan N, et al. Butyrate upregulates the TLR4 expression and the phosphorylation of MAPKs and NK-κB in colon cancer cell in vitro. Oncol Lett. 2018;16:4439-4447 pubmed 出版商
Hamon R, Tran H, Roscioli E, Ween M, Jersmann H, Hodge S. Bushfire smoke is pro-inflammatory and suppresses macrophage phagocytic function. Sci Rep. 2018;8:13424 pubmed 出版商
Li X, Ding M, Ding C, Li L, Feng J, Yu X. Toll‑Like receptor 4 promotes the phosphorylation of CRMP2 via the activation of Rho‑kinase in MCAO rats. Mol Med Rep. 2018;18:342-348 pubmed 出版商
Liang H, Lum H, Alvarez A, Garduno García J, Daniel B, Musi N. A low dose lipid infusion is sufficient to induce insulin resistance and a pro-inflammatory response in human subjects. PLoS ONE. 2018;13:e0195810 pubmed 出版商
Tobouti P, BOLT R, Radhakrishnan R, de Sousa S, Hunter K. Altered Toll-like receptor expression and function in HPV-associated oropharyngeal carcinoma. Oncotarget. 2018;9:236-248 pubmed 出版商
Wu B, Wang L, Jiang L, Dong L, Xu F, Lu Y, et al. n-butanol extract from Folium isatidis inhibits the lipopolysaccharide-induced downregulation of CXCR1 and CXCR2 on human neutrophils. Mol Med Rep. 2017;: pubmed 出版商
Trugilho M, Hottz E, Brunoro G, Teixeira Ferreira A, Carvalho P, Salazar G, et al. Platelet proteome reveals novel pathways of platelet activation and platelet-mediated immunoregulation in dengue. PLoS Pathog. 2017;13:e1006385 pubmed 出版商
Di Candia L, Gomez E, Venereau E, Chachi L, Kaur D, Bianchi M, et al. HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4. J Allergy Clin Immunol. 2017;140:584-587.e8 pubmed 出版商
Li Q, Bao F, Zhi D, Liu M, Yan Q, Zheng X, et al. Lipopolysaccharide induces SBD-1 expression via the P38 MAPK signaling pathway in ovine oviduct epithelial cells. Lipids Health Dis. 2016;15:127 pubmed 出版商
Nakstad B, Sonerud T, Solevåg A. Early detection of neonatal group B streptococcus sepsis and the possible diagnostic utility of IL-6, IL-8, and CD11b in a human umbilical cord blood in vitro model. Infect Drug Resist. 2016;9:171-9 pubmed 出版商
Shi R, Wang Q, Ouyang Y, Wang Q, Xiong X. Picfeltarraenin IA inhibits lipopolysaccharide-induced inflammatory cytokine production by the nuclear factor-κB pathway in human pulmonary epithelial A549 cells. Oncol Lett. 2016;11:1195-1200 pubmed
Chiappini N, Cantisani R, Pancotto L, Ruggiero P, Rosa D, Manetti A, et al. Innate Response Activator (IRA) B Cells Reside in Human Tonsils and Internalize Bacteria In Vitro. PLoS ONE. 2015;10:e0129879 pubmed 出版商
Avlas O, Bragg A, Fuks A, Nicholson J, Farkash A, Porat E, et al. TLR4 Expression Is Associated with Left Ventricular Dysfunction in Patients Undergoing Coronary Artery Bypass Surgery. PLoS ONE. 2015;10:e0120175 pubmed 出版商
Eichholz K, Mennechet F, Kremer E. Human coagulation factor X-adenovirus type 5 complexes poorly stimulate an innate immune response in human mononuclear phagocytes. J Virol. 2015;89:2884-91 pubmed 出版商
Johnston J, Nickerson J, Daroszewski J, Mogg T, Burton G. Biologically active polymers from spontaneous carotenoid oxidation: a new frontier in carotenoid activity. PLoS ONE. 2014;9:e111346 pubmed 出版商
Liaunardy Jopeace A, Bryant C, Gay N. The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane. Sci Signal. 2014;7:ra70 pubmed 出版商
Rivadeneyra L, Carestia A, Etulain J, Pozner R, Fondevila C, Negrotto S, et al. Regulation of platelet responses triggered by Toll-like receptor 2 and 4 ligands is another non-genomic role of nuclear factor-kappaB. Thromb Res. 2014;133:235-43 pubmed 出版商
Young B, Stanic A, Panda B, Rueda B, Panda A. Longitudinal expression of Toll-like receptors on dendritic cells in uncomplicated pregnancy and postpartum. Am J Obstet Gynecol. 2014;210:445.e1-6 pubmed 出版商
Xu L, Feng X, Tan W, Gu W, Guo D, Zhang M, et al. IL-29 enhances Toll-like receptor-mediated IL-6 and IL-8 production by the synovial fibroblasts from rheumatoid arthritis patients. Arthritis Res Ther. 2013;15:R170 pubmed 出版商
Bretz N, Ridinger J, Rupp A, Rimbach K, Keller S, Rupp C, et al. Body fluid exosomes promote secretion of inflammatory cytokines in monocytic cells via Toll-like receptor signaling. J Biol Chem. 2013;288:36691-702 pubmed 出版商
Trop S, Marshall J, Mazer C, Gupta M, Dumont D, Bourdeau A, et al. Perioperative cardiovascular system failure in South Asians undergoing cardiopulmonary bypass is associated with prolonged inflammation and increased Toll-like receptor signaling in inflammatory monocytes. J Surg Res. 2014;187:43-52 pubmed 出版商
Huizinga R, van Rijs W, Bajramovic J, Kuijf M, Laman J, Samsom J, et al. Sialylation of Campylobacter jejuni endotoxin promotes dendritic cell-mediated B cell responses through CD14-dependent production of IFN-? and TNF-?. J Immunol. 2013;191:5636-45 pubmed 出版商
Ben Haij N, Leghmari K, Planès R, Thieblemont N, Bahraoui E. HIV-1 Tat protein binds to TLR4-MD2 and signals to induce TNF-? and IL-10. Retrovirology. 2013;10:123 pubmed 出版商
Suurmond J, Stoop J, Rivellese F, Bakker A, Huizinga T, Toes R. Activation of human basophils by combined toll-like receptor- and Fc?RI-triggering can promote Th2 skewing of naive T helper cells. Eur J Immunol. 2014;44:386-96 pubmed 出版商
Nazli A, Kafka J, Ferreira V, Anipindi V, Mueller K, Osborne B, et al. HIV-1 gp120 induces TLR2- and TLR4-mediated innate immune activation in human female genital epithelium. J Immunol. 2013;191:4246-58 pubmed 出版商
Haddadi S, Kim D, Jasmine H, van der Meer F, Czub M, Abdul Careem M. Induction of Toll-like receptor 4 signaling in avian macrophages inhibits infectious laryngotracheitis virus replication in a nitric oxide dependent way. Vet Immunol Immunopathol. 2013;155:270-5 pubmed 出版商
Ojaimi S, Skinner N, Strauss B, Sundararajan V, Woolley I, Visvanathan K. Vitamin D deficiency impacts on expression of toll-like receptor-2 and cytokine profile: a pilot study. J Transl Med. 2013;11:176 pubmed 出版商
Potnis P, Dutta D, Wood S. Toll-like receptor 4 signaling pathway mediates proinflammatory immune response to cobalt-alloy particles. Cell Immunol. 2013;282:53-65 pubmed 出版商
Zhang G, Chen F, Cao Y, See W. Contributors to HMGB1 release by urothelial carcinoma cells in response to bacillus Calmette-Guérin. J Urol. 2013;190:1398-403 pubmed 出版商
Ramani V, Madhusoodhanan R, Kosanke S, Awasthi S. A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation. Innate Immun. 2013;19:596-610 pubmed 出版商
Velegraki M, Papakonstanti E, Mavroudi I, Psyllaki M, Tsatsanis C, Oulas A, et al. Impaired clearance of apoptotic cells leads to HMGB1 release in the bone marrow of patients with myelodysplastic syndromes and induces TLR4-mediated cytokine production. Haematologica. 2013;98:1206-15 pubmed 出版商
Freeman C, Martinez F, Han M, Washko G, McCubbrey A, Chensue S, et al. Lung CD8+ T cells in COPD have increased expression of bacterial TLRs. Respir Res. 2013;14:13 pubmed 出版商
Cheng A, Dong Y, Zhu F, Liu Y, Hou F, Nie J. AGE-LDL activates Toll like receptor 4 pathway and promotes inflammatory cytokines production in renal tubular epithelial cells. Int J Biol Sci. 2013;9:94-107 pubmed 出版商
Huang X, Yi J, Yin S, Chen R, Li M, Gong Z, et al. Exposure to heat-inactivated Trichophyton rubrum resulting in a limited immune response of human keratinocytes. Chin Med J (Engl). 2013;126:215-9 pubmed
Liang L, Tan X, Zhou Q, Zhu Y, Tian Y, Yu H, et al. IL-1? triggered by peptidoglycan and lipopolysaccharide through TLR2/4 and ROS-NLRP3 inflammasome-dependent pathways is involved in ocular Behçet's disease. Invest Ophthalmol Vis Sci. 2013;54:402-14 pubmed 出版商
Harman A, Bye C, Nasr N, Sandgren K, Kim M, Mercier S, et al. Identification of lineage relationships and novel markers of blood and skin human dendritic cells. J Immunol. 2013;190:66-79 pubmed 出版商
Osterbur K, Yu D, DeClue A. Interleukin-1?, tumour necrosis factor-? and lipopolysaccharide induce C-type natriuretic peptide from canine aortic endothelial cells. Res Vet Sci. 2013;94:478-83 pubmed 出版商
Mayumi N, Watanabe E, Norose Y, Watari E, Kawana S, Geijtenbeek T, et al. E-cadherin interactions are required for Langerhans cell differentiation. Eur J Immunol. 2013;43:270-80 pubmed 出版商
Jalilian I, Spildrejorde M, Seavers A, Curtis B, McArthur J, Sluyter R. Functional expression of the damage-associated molecular pattern receptor P2X7 on canine kidney epithelial cells. Vet Immunol Immunopathol. 2012;150:228-33 pubmed 出版商
Furugen R, Hayashida H, Saito T. Porphyromonas gingivalis and Escherichia coli lipopolysaccharide causes resistin release from neutrophils. Oral Dis. 2013;19:479-83 pubmed 出版商
Jonker M, Wubben J, Haanstra K, Vierboom M, t Hart B. Comparative analysis of inflammatory infiltrates in collagen-induced arthritis, kidney graft rejection and delayed-type hypersensitivity in non-human primates. Inflamm Res. 2013;62:181-94 pubmed 出版商
Belmonte L, Beutheu Youmba S, Bertiaux Vandaële N, Antonietti M, Lecleire S, Zalar A, et al. Role of toll like receptors in irritable bowel syndrome: differential mucosal immune activation according to the disease subtype. PLoS ONE. 2012;7:e42777 pubmed 出版商
Kim K, Jo M, Suh D, Yoon M, Shin D, Lee J, et al. Expression and significance of the TLR4/MyD88 signaling pathway in ovarian epithelial cancers. World J Surg Oncol. 2012;10:193 pubmed 出版商
Yoshino H, Kashiwakura I. Impairment of mature dendritic cells derived from X-irradiated human monocytes depends on the type of maturation stimulus used. Radiat Res. 2012;178:280-8 pubmed
Al ofi E, Coffelt S, Anumba D. Monocyte subpopulations from pre-eclamptic patients are abnormally skewed and exhibit exaggerated responses to Toll-like receptor ligands. PLoS ONE. 2012;7:e42217 pubmed 出版商
Das S, Rani M, Pandey K, Sahoo G, Rabidas V, Singh D, et al. Combination of paromomycin and miltefosine promotes TLR4-dependent induction of antileishmanial immune response in vitro. J Antimicrob Chemother. 2012;67:2373-8 pubmed 出版商
Leoratti F, Trevelin S, Cunha F, Rocha B, Costa P, Gravina H, et al. Neutrophil paralysis in Plasmodium vivax malaria. PLoS Negl Trop Dis. 2012;6:e1710 pubmed 出版商
Ichii H, Masuda Y, Hassanzadeh T, Saffarian M, Gollapudi S, Vaziri N. Iron sucrose impairs phagocytic function and promotes apoptosis in polymorphonuclear leukocytes. Am J Nephrol. 2012;36:50-7 pubmed 出版商
Sato K, Yoshimura A, Kaneko T, Ukai T, Ozaki Y, Nakamura H, et al. A single nucleotide polymorphism in 3'-untranslated region contributes to the regulation of Toll-like receptor 4 translation. J Biol Chem. 2012;287:25163-72 pubmed 出版商
de Jong P, Schadenberg A, van den Broek T, Beekman J, van Wijk F, Coffer P, et al. STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass. PLoS ONE. 2012;7:e35070 pubmed 出版商
Nair A, Kanda V, Bush Joseph C, Verma N, Chubinskaya S, Mikecz K, et al. Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14. Arthritis Rheum. 2012;64:2268-77 pubmed 出版商
Garbe K, Bratke K, Wagner S, Virchow J, Lommatzsch M. Plasmacytoid dendritic cells and their Toll-like receptor 9 expression selectively decrease with age. Hum Immunol. 2012;73:493-7 pubmed 出版商
Sivaram G, Tiwari S, Bardia A, Anjum F, Vishnupriya S, Habeeb A, et al. Macrophage migration inhibitory factor, Toll-like receptor 4, and CD14 polymorphisms with altered expression levels in patients with ulcerative colitis. Hum Immunol. 2012;73:201-5 pubmed 出版商
Chávez Galán L, Sada Ovalle I, Báez Saldaña R, Chavez R, Lascurain R. Monocytes from tuberculosis patients that exhibit cleaved caspase 9 and denaturalized cytochrome c are more susceptible to death mediated by Toll-like receptor 2. Immunology. 2012;135:299-311 pubmed 出版商
Nadigel J, Préfontaine D, Baglole C, Maltais F, Bourbeau J, Eidelman D, et al. Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease. Respir Res. 2011;12:149 pubmed 出版商
Hill M, Deghmane A, Segovia M, Zarantonelli M, Tilly G, Blancou P, et al. Penicillin binding proteins as danger signals: meningococcal penicillin binding protein 2 activates dendritic cells through Toll-like receptor 4. PLoS ONE. 2011;6:e23995 pubmed 出版商
Aguilar Ruiz S, Torres Aguilar H, González Domínguez E, Narváez J, González Pérez G, Vargas Ayala G, et al. Human CD16+ and CD16- monocyte subsets display unique effector properties in inflammatory conditions in vivo. J Leukoc Biol. 2011;90:1119-31 pubmed 出版商
Doi H, Iyer T, Carpenter E, Li H, Chang K, Vonderheide R, et al. Dysfunctional B-cell activation in cirrhosis resulting from hepatitis C infection associated with disappearance of CD27-positive B-cell population. Hepatology. 2012;55:709-19 pubmed 出版商
Allam J, Duan Y, Heinemann F, Winter J, Gotz W, Deschner J, et al. IL-23-producing CD68(+) macrophage-like cells predominate within an IL-17-polarized infiltrate in chronic periodontitis lesions. J Clin Periodontol. 2011;38:879-86 pubmed 出版商
Sen A, Chowdhury I, Mukhopadhyay D, Paine S, Mukherjee A, Mondal L, et al. Increased Toll-like receptor-2 expression on nonclassic CD16+ monocytes from patients with inflammatory stage of Eales' disease. Invest Ophthalmol Vis Sci. 2011;52:6940-8 pubmed 出版商
Scian R, Barrionuevo P, Giambartolomei G, De Simone E, Vanzulli S, Fossati C, et al. Potential role of fibroblast-like synoviocytes in joint damage induced by Brucella abortus infection through production and induction of matrix metalloproteinases. Infect Immun. 2011;79:3619-32 pubmed 出版商
Geraghty P, Dabo A, D ARMIENTO J. TLR4 protein contributes to cigarette smoke-induced matrix metalloproteinase-1 (MMP-1) expression in chronic obstructive pulmonary disease. J Biol Chem. 2011;286:30211-8 pubmed 出版商
Caras I, Tucureanu C, Pitica R, Salageanu A. Bacterial extract cantastim activates macrophages via TLR-2. Roum Arch Microbiol Immunol. 2011;70:28-36 pubmed
Semeraro F, Ammollo C, Morrissey J, Dale G, Friese P, Esmon N, et al. Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood. 2011;118:1952-61 pubmed 出版商
Colmont C, Raby A, Dioszeghy V, LeBouder E, Foster T, Jones S, et al. Human peritoneal mesothelial cells respond to bacterial ligands through a specific subset of Toll-like receptors. Nephrol Dial Transplant. 2011;26:4079-90 pubmed 出版商
Khoo A, Chai L, Koenen H, Oosting M, Steinmeyer A, Zuegel U, et al. Vitamin D(3) down-regulates proinflammatory cytokine response to Mycobacterium tuberculosis through pattern recognition receptors while inducing protective cathelicidin production. Cytokine. 2011;55:294-300 pubmed 出版商
Li W, Katz B, Spinola S. Haemophilus ducreyi lipooligosaccharides induce expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase via type I interferons and tumor necrosis factor alpha in human dendritic cells. Infect Immun. 2011;79:3338-47 pubmed 出版商
Liang J, Jiang D, Jung Y, Xie T, Ingram J, Church T, et al. Role of hyaluronan and hyaluronan-binding proteins in human asthma. J Allergy Clin Immunol. 2011;128:403-411.e3 pubmed 出版商
Nanthakumar N, Meng D, Goldstein A, Zhu W, Lu L, Uauy R, et al. The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: an immature innate immune response. PLoS ONE. 2011;6:e17776 pubmed 出版商
von Scheele I, Larsson K, Dahlen B, Billing B, Skedinger M, Lantz A, et al. Toll-like receptor expression in smokers with and without COPD. Respir Med. 2011;105:1222-30 pubmed 出版商
Awasthi S, Madhusoodhanan R, Wolf R. Surfactant protein-A and toll-like receptor-4 modulate immune functions of preterm baboon lung dendritic cell precursor cells. Cell Immunol. 2011;268:87-96 pubmed 出版商
Suzuki K, Murakami T, Kuwahara Arai K, Tamura H, Hiramatsu K, Nagaoka I. Human anti-microbial cathelicidin peptide LL-37 suppresses the LPS-induced apoptosis of endothelial cells. Int Immunol. 2011;23:185-93 pubmed 出版商
Wang M, Chen Y, Zhang Y, Zhang L, Lu X, Chen Z. Mannan-binding lectin directly interacts with Toll-like receptor 4 and suppresses lipopolysaccharide-induced inflammatory cytokine secretion from THP-1 cells. Cell Mol Immunol. 2011;8:265-75 pubmed 出版商
Jozefowski S, Czerkies M, Sobota A, Kwiatkowska K. Determination of cell surface expression of Toll-like receptor 4 by cellular enzyme-linked immunosorbent assay and radiolabeling. Anal Biochem. 2011;413:185-91 pubmed 出版商
Khoo A, Chai L, Koenen H, Sweep F, Joosten I, Netea M, et al. Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals. Clin Exp Immunol. 2011;164:72-9 pubmed 出版商
Coler R, Bertholet S, Moutaftsi M, Guderian J, Windish H, Baldwin S, et al. Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant. PLoS ONE. 2011;6:e16333 pubmed 出版商
Perez Barcena J, Crespí C, Regueiro V, Marsé P, Raurich J, Ibáñez J, et al. Lack of effect of glutamine administration to boost the innate immune system response in trauma patients in the intensive care unit. Crit Care. 2010;14:R233 pubmed 出版商
Khoo A, Chai L, Koenen H, Kullberg B, Joosten I, van der Ven A, et al. 1,25-dihydroxyvitamin D3 modulates cytokine production induced by Candida albicans: impact of seasonal variation of immune responses. J Infect Dis. 2011;203:122-30 pubmed 出版商
He K, Sui G, Xiong H, Broekman M, Huang B, Marcus A, et al. Feedback regulation of endothelial cell surface plasmin generation by PKC-dependent phosphorylation of annexin A2. J Biol Chem. 2011;286:15428-39 pubmed 出版商
Barrionuevo P, Delpino M, Velásquez L, García Samartino C, Coria L, Ibañez A, et al. Brucella abortus inhibits IFN-?-induced Fc?RI expression and Fc?RI-restricted phagocytosis via toll-like receptor 2 on human monocytes/macrophages. Microbes Infect. 2011;13:239-50 pubmed 出版商
Dasari P, Zola H, Nicholson I. Expression of Toll-like receptors by neonatal leukocytes. Pediatr Allergy Immunol. 2011;22:221-8 pubmed 出版商
Tanaka S, Koizumi S, Makiuchi N, Aoyagi Y, Quivy E, Mitamura R, et al. The extract of Japanese soybean, Kurosengoku activates the production of IL-12 and IFN-? by DC or NK1.1(+) cells in a TLR4- and TLR2-dependent manner. Cell Immunol. 2011;266:135-42 pubmed 出版商
Scian R, Barrionuevo P, Giambartolomei G, Fossati C, Baldi P, Delpino M. Granulocyte-macrophage colony-stimulating factor- and tumor necrosis factor alpha-mediated matrix metalloproteinase production by human osteoblasts and monocytes after infection with Brucella abortus. Infect Immun. 2011;79:192-202 pubmed 出版商
de Mast Q, de Groot P, van Heerde W, Roestenberg M, van Velzen J, Verbruggen B, et al. Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy. Br J Haematol. 2010;151:495-503 pubmed 出版商
Holmlund U, Amoudruz P, Johansson M, Haileselassie Y, Ongoiba A, Kayentao K, et al. Maternal country of origin, breast milk characteristics and potential influences on immunity in offspring. Clin Exp Immunol. 2010;162:500-9 pubmed 出版商
Zhang J, Yang Y, Levy O, Chen C. Human neonatal peripheral blood leukocytes demonstrate pathogen-specific coordinate expression of TLR2, TLR4/MD2, and MyD88 during bacterial infection in vivo. Pediatr Res. 2010;68:479-83 pubmed 出版商
Gomes N, Brunialti M, Mendes M, Freudenberg M, Galanos C, Salomao R. Lipopolysaccharide-induced expression of cell surface receptors and cell activation of neutrophils and monocytes in whole human blood. Braz J Med Biol Res. 2010;43:853-8 pubmed
Sturges N, Wikstrom M, Winfield K, Gard S, Brennan S, Sly P, et al. Monocytes from children with clinically stable cystic fibrosis show enhanced expression of Toll-like receptor 4. Pediatr Pulmonol. 2010;45:883-9 pubmed 出版商
Soylu A, Ates H, Cingoz S, Turkmen M, Demir B, Tunca M, et al. TLR polymorphisms in FMF: association of TLR-2 (Arg753Gln) and TLR-4 (Asp299Gly, Thre399Ile) polymorphisms and myeloid cell TLR-2 and TLR-4 expression with the development of secondary amyloidosis in FMF. Inflammation. 2011;34:379-87 pubmed 出版商
Lang L, Wang L, Liu L. Exogenous MD-2 confers lipopolysaccharide responsiveness to human corneal epithelial cells with intracellular expression of TLR4 and CD14. Inflammation. 2011;34:371-8 pubmed 出版商
Chung H, Watanabe T, Kudo M, Chiba T. Hepatitis C virus core protein induces homotolerance and cross-tolerance to Toll-like receptor ligands by activation of Toll-like receptor 2. J Infect Dis. 2010;202:853-61 pubmed 出版商
Préfontaine D, Banville Langelier A, Fiset P, Guay J, An J, Mazer M, et al. Children with atopic histories exhibit impaired lipopolysaccharide-induced Toll-like receptor-4 signalling in peripheral monocytes. Clin Exp Allergy. 2010;40:1648-57 pubmed 出版商
Quevedo Diaz M, Song C, Xiong Y, Chen H, Wahl L, Radulovic S, et al. Involvement of TLR2 and TLR4 in cell responses to Rickettsia akari. J Leukoc Biol. 2010;88:675-85 pubmed 出版商
Ahmad U, Ali R, Lebastchi A, Qin L, Lo S, Yakimov A, et al. IFN-gamma primes intact human coronary arteries and cultured coronary smooth muscle cells to double-stranded RNA- and self-RNA-induced inflammatory responses by upregulating TLR3 and melanoma differentiation-associated gene 5. J Immunol. 2010;185:1283-94 pubmed 出版商
Kuijf M, Samsom J, van Rijs W, Bax M, Huizinga R, Heikema A, et al. TLR4-mediated sensing of Campylobacter jejuni by dendritic cells is determined by sialylation. J Immunol. 2010;185:748-55 pubmed 出版商
Loser K, Vogl T, Voskort M, Lueken A, Kupas V, Nacken W, et al. The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells. Nat Med. 2010;16:713-7 pubmed 出版商
Burger Kentischer A, Abele I, Finkelmeier D, Wiesmüller K, Rupp S. A new cell-based innate immune receptor assay for the examination of receptor activity, ligand specificity, signalling pathways and the detection of pyrogens. J Immunol Methods. 2010;358:93-103 pubmed 出版商
Shin S, Lee Y. Airborne fungi induce nasal polyp epithelial cell activation and Toll-like receptor expression. Int Arch Allergy Immunol. 2010;153:46-52 pubmed 出版商
Drewniak A, Tool A, Geissler J, van Bruggen R, van den Berg T, Kuijpers T. Toll-like receptor-induced reactivity and strongly potentiated IL-8 production in granulocytes mobilized for transfusion purposes. Blood. 2010;115:4588-96 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
CD284 (TLR4) Monoclonal Antibody (HTA125), Alexa Fluor™ 488, eBioscience
目录# :
53-9917-41
规格 :
25试验
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 5 µL (1 µg)/test
物种 :
人类
克隆 :
HTA125
抗体亚型 :
IgG2a, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
TLR4 is member of the Toll like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. Mammalian cells respond to LPS by activating TLR4. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. TLR4 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. Mutations in the TLR4 gene have been associated with differences in LPS responsiveness. Also, several transcript variants of the TLR4 gene have been found, but the protein coding potential of most of them is uncertain. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 5 µL (1 µg)/test
别名 :
ARMD10; CD284; EGK_07381; homolog of Drosophila toll; hToll; lipopolysaccharide response; Lps; Ly87; Ran/M1; Rasl2-8; Tlr4; TLR-4; TOLL; toll like receptor 4; toll/interleukin-l receptor (TIR) domain; toll4; toll-like receptor 4; toll-like receptor 4 immunity-related protein; Toll-like receptor 4-like protein; Toll-like receptor4 protein
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国