产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
STAT4重组兔单克隆抗体(2H9L5)
目录 :
700185
规格 :
100微克
价格 :
美国425.00
克隆性 :
重组
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
2H9L5
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
产品类型 :
抗体
产品名称 :
STAT4重组兔单克隆抗体(2H9L5)
目录# :
700185
规格 :
100微克
价格 :
美国425.00
克隆性 :
重组单克隆
纯度 :
蛋白质A
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用 :
ELISA: 1-5 µg/mL, Flow Cytometry: 1:100-1:500, Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 3-5 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
2H9L5
抗体亚型 :
IgG
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
STAT4 was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins. The STAT4 protein is most similar to STAT1 (52%) and STAT3 (47%). Functionally, STAT4 is similar to other STAT family members in that it can be tyrosine phosphorylated by Jak1 or Jak2. STAT4 forms homodimers and heterodimers with related STAT family members. Tyrosine phosphorylated STAT4 can bind the IFN-gamma activated site (GAS). Serine phosphorylation of STAT is also required for maximal transcriptional activity. STAT4 expression is restricted to the thymus, spleen and testis. Until recently the cytokine(s) responsible for activation of STAT4 had not been identified. STAT4 is now known to be activated by the cytokine interleukin 12 (IL-12). IL-12 is required for the T-cell independent induction of IFN-gamma which is a key step in the initial suppression of bacterial and parasitic infections. In addition, IL-12 is required for the development of a Th1 response which is necessary for effective host defense against intracellular pathogens. STAT4-deficient mice display impaired IL-12 development of Th1 cells and enhanced development of Th2 cells. A recent study in mouse has shown that in response to viral infection IFN-a/b activation of STAT4 is required for IFN-g production.
免疫原 :
A peptide corresponding to amino acids 730-748 of Q14765.
格式 :
液体
应用w/稀释 :
ELISA: 1-5 µg/mL, Flow Cytometry: 1:100-1:500, Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 3-5 µg/mL
别名 :
CIS4; HSPC060; OTTHUMP00000163553; Signal transducer and activator of transcription 4; SLEB11; SOCS4; SOCS6; SSI4; STAI4; STAT; Stat4; STATI4
更多信息或购买 :
公司信息
赛默飞世尔