产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
乙淀粉样蛋白重组兔单克隆抗体(H31L21)
目录 :
700254
规格 :
100微克
价格 :
美国375.00
克隆性 :
重组
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
H31L21
反应物种 :
African green monkey, 人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫组化-自由浮动切片, dot blot
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 36
出版应用/物种/样本/稀释参考文献
  • 免疫组化-冰冻切片; African green monkey; 1:2500; 图 1d
Edler M, Sherwood C, Meindl R, Hopkins W, Ely J, Erwin J, et al. Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease. Neurobiol Aging. 2017;59:107-120 pubmed 出版商
  • 免疫印迹; 人类; 图 6b
Rocchi A, Yamamoto S, Ting T, Fan Y, SADLEIR K, Wang Y, et al. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. PLoS Genet. 2017;13:e1006962 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:200; 图 st1
Klementieva O, Willén K, Martinsson I, Israelsson B, Engdahl A, Cladera J, et al. Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP. Nat Commun. 2017;8:14726 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 图 1a
Lejbman N, OLIVERA A, Heinzelmann M, Feng R, Yun S, Kim H, et al. Active duty service members who sustain a traumatic brain injury have chronically elevated peripheral concentrations of A?40 and lower ratios of A?42/40. Brain Inj. 2016;30:1436-1441 pubmed
  • dot blot; 小鼠; 1:1000; 图 6a
  • 免疫组化; 小鼠; 1:500; 图 6b
Fan Y, Wang N, Rocchi A, Zhang W, Vassar R, Zhou Y, et al. Identification of natural products with neuronal and metabolic benefits through autophagy induction. Autophagy. 2017;13:41-56 pubmed 出版商
  • 免疫组化; 小鼠; 图 2a
  • 酶联免疫吸附测定; 小鼠; 图 5a
  • 免疫印迹; 小鼠; 图 1f
Dinkins M, Enasko J, Hernandez C, Wang G, Kong J, Helwa I, et al. Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse. J Neurosci. 2016;36:8653-67 pubmed 出版商
  • 免疫组化; 小鼠; 图 7e
Badea A, Kane L, Anderson R, Qi Y, Foster M, Cofer G, et al. The fornix provides multiple biomarkers to characterize circuit disruption in a mouse model of Alzheimer's disease. Neuroimage. 2016;142:498-511 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:600; 图 1b
Sadleir K, Kandalepas P, Buggia Prevot V, Nicholson D, Thinakaran G, Vassar R. Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease. Acta Neuropathol. 2016;132:235-56 pubmed 出版商
  • 免疫组化-自由浮动切片; 人类; 1:100; 表 2
Perez S, Sherwood C, Cranfield M, Erwin J, Mudakikwa A, Hof P, et al. Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei). Neurobiol Aging. 2016;39:195-201 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠
Kan M, Lee J, Wilson J, Everhart A, Brown C, Hoofnagle A, et al. Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. J Neurosci. 2015;35:5969-82 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 4
Postupna N, Keene C, Crane P, Gonzalez Cuyar L, Sonnen J, Hewitt J, et al. Cerebral cortical Aβ42 and PHF-Ï„ in 325 consecutive brain autopsies stratified by diagnosis, location, and APOE. J Neuropathol Exp Neurol. 2015;74:100-9 pubmed 出版商
  • 酶联免疫吸附测定; 小鼠; 图 3
  • 免疫印迹; 小鼠; 1:2500; 图 2
Sadleir K, Eimer W, Cole S, Vassar R. Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level. Mol Neurodegener. 2015;10:1 pubmed 出版商
  • 免疫细胞化学; 人类; 1:2000
Wu Z, Guo Z, Gearing M, Chen G. Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer's [corrected] disease model. Nat Commun. 2014;5:4159 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:500
Washington P, Morffy N, Parsadanian M, Zapple D, Burns M. Experimental traumatic brain injury induces rapid aggregation and oligomerization of amyloid-beta in an Alzheimer's disease mouse model. J Neurotrauma. 2014;31:125-34 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Li W, Tang Y, Fan Z, Meng Y, Yang G, Luo J, et al. Autophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide. Mol Neurodegener. 2013;8:27 pubmed 出版商
  • 免疫印迹; 人类; 1:2500
Sadleir K, Bennett D, Schneider J, Vassar R. Elevated A?42 in aged, non-demented individuals with cerebral atherosclerosis. Curr Alzheimer Res. 2013;10:785-9 pubmed
  • 免疫组化-冰冻切片; 小鼠; 1:60
Toth M, Szegedi V, Varga E, Juhasz G, Horváth J, Borbély E, et al. Overexpression of Hsp27 ameliorates symptoms of Alzheimer's disease in APP/PS1 mice. Cell Stress Chaperones. 2013;18:759-71 pubmed 出版商
  • 免疫组化-自由浮动切片; 小鼠; 1:1000
Eimer W, Vassar R. Neuron loss in the 5XFAD mouse model of Alzheimer's disease correlates with intraneuronal A?42 accumulation and Caspase-3 activation. Mol Neurodegener. 2013;8:2 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 0.1 ug/ml
Zetterberg H, Mörtberg E, Song L, Chang L, Provuncher G, Patel P, et al. Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid ? levels in humans. PLoS ONE. 2011;6:e28263 pubmed 出版商
Elsherbini A, Kirov A, Dinkins M, Wang G, Qin H, Zhu Z, et al. Association of Aβ with ceramide-enriched astrosomes mediates Aβ neurotoxicity. Acta Neuropathol Commun. 2020;8:60 pubmed 出版商
Carreras I, Aytan N, Choi J, Tognoni C, Kowall N, Jenkins B, et al. Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer's disease. Sci Rep. 2019;9:10972 pubmed 出版商
Leyns C, Gratuze M, Narasimhan S, Jain N, Koscal L, Jiang H, et al. TREM2 function impedes tau seeding in neuritic plaques. Nat Neurosci. 2019;: pubmed 出版商
More J, Galusso N, Veloso P, Montecinos L, Finkelstein J, Sanchez G, et al. N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer's Disease Rat Model. Front Aging Neurosci. 2018;10:399 pubmed 出版商
Keene C, Wilson A, Kilgore M, Bruner L, Postupna N, Darvas M. Luminex-based quantification of Alzheimer's disease neuropathologic change in formalin-fixed post-mortem human brain tissue. Lab Invest. 2018;: pubmed 出版商
Sadleir K, Popovic J, Vassar R. ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease. J Biol Chem. 2018;293:18434-18443 pubmed 出版商
Ilievski V, Zuchowska P, Green S, Toth P, Ragozzino M, Le K, et al. Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice. PLoS ONE. 2018;13:e0204941 pubmed 出版商
Milanovic D, Petrović S, Brkic M, Avramović V, Perovic M, Ivkovic S, et al. Short-Term Fish Oil Treatment Changes the Composition of Phospholipids While Not Affecting the Expression of Mfsd2a Omega-3 Transporter in the Brain and Liver of the 5xFAD Mouse Model of Alzheimer's Disease. Nutrients. 2018;10: pubmed 出版商
Eimer W, Vijaya Kumar D, Navalpur Shanmugam N, Rodriguez A, Mitchell T, Washicosky K, et al. Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection. Neuron. 2018;99:56-63.e3 pubmed 出版商
Chai Q, Jovasevic V, Malikov V, Sabo Y, MORHAM S, Walsh D, et al. HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration. Nat Commun. 2017;8:1522 pubmed 出版商
Willén K, Sroka A, Takahashi R, Gouras G. Heterogeneous Association of Alzheimer's Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses. J Alzheimers Dis. 2017;60:511-524 pubmed 出版商
Willén K, Edgar J, Hasegawa T, Tanaka N, Futter C, Gouras G. A? accumulation causes MVB enlargement and is modelled by dominant negative VPS4A. Mol Neurodegener. 2017;12:61 pubmed 出版商
Ubelmann F, Burrinha T, Salavessa L, Gomes R, Ferreira C, Moreno N, et al. Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep. 2017;18:102-122 pubmed 出版商
Condello C, Yuan P, Schain A, Grutzendler J. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. Nat Commun. 2015;6:6176 pubmed 出版商
Dinkins M, Dasgupta S, Wang G, Zhu G, Bieberich E. Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease. Neurobiol Aging. 2014;35:1792-800 pubmed 出版商
Perez S, Raghanti M, Hof P, Kramer L, Ikonomovic M, Lacor P, et al. Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla). J Comp Neurol. 2013;521:4318-38 pubmed 出版商
Zhang Q, Wang R, Scott E, Han D, Dong Y, Tu J, et al. Hypersensitivity of the hippocampal CA3 region to stress-induced neurodegeneration and amyloidogenesis in a rat model of surgical menopause. Brain. 2013;136:1432-45 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
乙淀粉样蛋白重组兔单克隆抗体(H31L21)
目录# :
700254
规格 :
100微克
价格 :
美国375.00
克隆性 :
重组单克隆
纯度 :
蛋白质A
宿主 :
兔
反应物种 :
人类, 小鼠
应用 :
ELISA:0.1 0.2微克/毫升, 免疫组化(石蜡):1微克/毫升
物种 :
人类, 小鼠
克隆 :
H31L21
抗体亚型 :
IgG
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer's disease. Abeta peptide is 40-43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease, beta-secretase (BACE) which is synthesized as a propeptide and must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP, and a membrane-bound remnant. The remnant protein is processed by another protease, gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. The transmembrane glycoprotein, nicastrin, is associated with presinilins and has been found to bind to the carboxyl-terminus of beta APP and helps to modulate the production of the amyloid beta peptide. Abeta is an extracellular filamentous protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles. Alzheimer’s disease, the most common cause of senile dementia, is characterized by abnormal filamentous protein deposits in the brain. Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, amyloidosis (Dutch type), cerebroarterial amyloidosis (cerebral amyloid angiopathy) and in the Guam Parkinson-Dementia complex.
免疫原 :
A peptide corresponding to amino acids 707-713 of P05067.
格式 :
液体
应用w/稀释 :
ELISA:0.1 0.2微克/毫升, 免疫组化(石蜡):1微克/毫升
别名 :
A4; AAA; ABETA; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; Amyloid; amyloid A4; Amyloid b; Amyloid beta; amyloid beta (A4) precursor protein; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; amyloid precursor protein variant 1; amyloid precursor protein variant 2; Amyloid ß; amyloid-beta A4 protein; amyloid-beta A4 protein; amyloid beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; beta amyloid protein; beta amyloid protein precursor; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); Beta-amyloid precursor protein; betaApp; Beta-APP40; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTF gamma; CTF-alpha; CTFgamma; CVAP; E030013M08Rik; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; OTTHUMP00000096096; P3(40); P3(42); Pan-Abeta; peptidase nexin-II; PN2; PN-II; PreA4; PreA4 751; protease nexin II; protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国