产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
缺氧诱导因子1A抗体(16H4L13), ABfinity™兔单克隆
目录 :
700505
规格 :
100µg
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
共轭标签 :
nonconjugated
克隆名称 :
16H4L13
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫细胞化学
更多信息或购买 :
文章摘录数: 3
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 人类; 1:250; 图 s1a
Lima L, Gaiteiro C, Peixoto A, Soares J, Neves M, Santos L, et al. Reference Genes for Addressing Gene Expression of Bladder Cancer Cell Models under Hypoxia: A Step Towards Transcriptomic Studies. PLoS ONE. 2016;11:e0166120 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 6
Wood L, Cox N, Phelps C, Lai S, Poddar A, Talbot C, et al. Thyroid Transcription Factor 1 Reprograms Angiogenic Activities of Secretome. Sci Rep. 2016;6:19857 pubmed 出版商
Lazaridis I, Nadel D, Rollefson G, Merrett D, Rohland N, Mallick S, et al. Genomic insights into the origin of farming in the ancient Near East. Nature. 2016;536:419-24 pubmed
产品信息
产品类型 :
抗体
产品名称 :
缺氧诱导因子1A抗体(16H4L13), ABfinity™兔单克隆
目录# :
700505
规格 :
100µg
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
反应物种 :
人类
应用 :
ChIP assay: 1 µL, ELISA: Assay-dependent, Immunocytochemistry: 1:100-1:500, Immunofluorescence: 1:100-1:500, Western Blot: 1:500-1:5000
物种 :
人类
克隆 :
16H4L13
抗体亚型 :
IgG
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
HIF1-alpha (HIF1A) is a subunit of HIF1, which is a transcription factor found in mammalian cells cultured under reduced oxygen tension. HIF-1 is a heterodimer consisting of an alpha and beta subunit, both belonging to the basic-helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator-Sim (PAS) family of transcription factors. HIF1 functions as a transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, HIF-1 activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF1-alpha regulates hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis. Hypoxia which induces p53 protein accumulation, directly interacts with HIF1-alpha and reduces hypoxia-induced expression of HIF1-alpha by promoting MDM2-mediated ubiquitination and proteasomal degradation under hypoxic conditions. Recent studies suggest that induction of NOX4 by HIF1-alpha contributes to maintain ROS levels after hypoxia and hypoxia-induced proliferation. In humans, it is located on the q arm of chromosome 14. The C-terminal of HIF1A binds to p300. p300/CBP-HIF complexes participate in the induction of hypoxia-responsive genes, including VEGF. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease.
免疫原 :
proprietary
格式 :
Liquid
应用w/稀释 :
ChIP assay: 1 µL, ELISA: Assay-dependent, Immunocytochemistry: 1:100-1:500, Immunofluorescence: 1:100-1:500, Western Blot: 1:500-1:5000
别名 :
HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, ARNT interacting protein, ARNT-interacting protein, HIF-1-alpha, PAS domain-containing protein 8, basic-helix-loop-helix-PAS protein MOP1, class E basic helix-loop-helix protein 78, hypoxia-inducible factor 1 alpha isoform I.3, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), hypoxia-inducible factor 1-alpha, member of PAS protein 1, member of PAS superfamily 1
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
www.thermo.com.cn
1084193588
公司总部: 美国