产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Phospho-Tau (Ser199) Antibody (2H23L4), ABfinity™ Rabbit Monoclonal
目录 :
701054
规格 :
100µg
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
共轭标签 :
nonconjugated
抗原修饰 :
磷酸化
克隆名称 :
2H23L4
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 2
出版应用/物种/样品/稀释参考文献
  • 免疫印迹; 小鼠
  • 免疫印迹基因敲除验证; 人类; 1:500; 表 1
  • 免疫细胞化学; 人类; 1:100; 表 2
Ercan E, Eid S, Weber C, Kowalski A, Bichmann M, Behrendt A, et al. A validated antibody panel for the characterization of tau post-translational modifications. Mol Neurodegener. 2017;12:87 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Loeffler D, Smith L, Klaver A, Martic S. Effects of antibodies to phosphorylated and non-phosphorylated tau on in vitro tau phosphorylation at Serine-199: Preliminary report. Exp Gerontol. 2015;67:15-8 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
Phospho-Tau (Ser199) Antibody (2H23L4), ABfinity™ Rabbit Monoclonal
目录# :
701054
规格 :
100µg
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Immunohistochemistry (Paraffin): 1:50-1:500, Western Blot: 1:500-1:5000
物种 :
人类, 小鼠, 大鼠
克隆 :
2H23L4
抗体亚型 :
IgG
储存 :
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
描述 :
Tau protein plays a very important role in nucleation and stabilization of microtubules by associating with tubulin subunits. In humans, Tau is predominantly expressed in the brain, and is involved in neurodegeneration when the protein is misfolded, hyperphosphorylated, or self-assembles into tangles. Six isoforms of Tau with varying degree of affinity to tubulin exist. Numerous serine/threonine kinases, including GSK-3 beta, protein kinase A, and casein kinase II (CK2) phosphorylate Tau. Phosphorylation of the serine 396 residue is triggered through GSK-3beta and cdk5. The gene encoding the Tau protein consists of 16 exons, and is located at chromosomal locus 17q21.
免疫原 :
Phosphopeptide corresponding to amino acids 193–203 of human microtubule-associated protein tau
格式 :
Liquid
应用w/稀释 :
Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Immunohistochemistry (Paraffin): 1:50-1:500, Western Blot: 1:500-1:5000
别名 :
DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, TAU
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
www.thermo.com.cn
1084193588
公司总部: 美国