产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Phospho-Tau (Thr231) Antibody (1H6L6), ABfinity™ Rabbit Monoclonal
目录 :
701056
规格 :
100µg
价格 :
美国309.00
克隆性 :
单克隆
宿主 :
共轭标签 :
nonconjugated
抗原修饰 :
磷酸化
克隆名称 :
1H6L6
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 3
出版应用/物种/样品/稀释参考文献
  • 免疫印迹基因敲除验证; 人类; 1:500; 表 1
  • 免疫细胞化学; 人类; 1:100; 表 2
  • 免疫印迹; 小鼠
Ercan E, Eid S, Weber C, Kowalski A, Bichmann M, Behrendt A, et al. A validated antibody panel for the characterization of tau post-translational modifications. Mol Neurodegener. 2017;12:87 pubmed 出版商
  • 免疫组化-冰冻切片; 人类; 1:400; 图 4
  • 免疫组化-冰冻切片; 小鼠; 1:400; 图 4
Dengler Crish C, Smith M, Wilson G. Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease. J Alzheimers Dis. 2017;55:1605-1619 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Loeffler D, Smith L, Klaver A, Martić S. Effects of antibodies to phosphorylated and non-phosphorylated tau on in vitro tau phosphorylation at Serine-199: Preliminary report. Exp Gerontol. 2015;67:15-8 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
Phospho-Tau (Thr231) Antibody (1H6L6), ABfinity™ Rabbit Monoclonal
目录# :
701056
规格 :
100µg
价格 :
美国309.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
反应物种 :
人类, 大鼠
应用 :
Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Immunohistochemistry (Paraffin): 1:50-1:500, Western Blot: 1:500-1:5000
物种 :
人类, 大鼠
克隆 :
1H6L6
抗体亚型 :
IgG
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
Phosphopeptide corresponding to amino acids 224–236 of human microtubule-associated protein tau
格式 :
Liquid
应用w/稀释 :
Immunocytochemistry: 1:100-1:1000, Immunofluorescence: 1:100-1:1000, Immunohistochemistry (Paraffin): 1:50-1:500, Western Blot: 1:500-1:5000
别名 :
DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, TAU
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
www.thermo.com.cn
1084193588
公司总部: 美国