产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
alpha突触核蛋白重组兔单克隆抗体(14H2L1)
目录 :
701085
规格 :
100微克
价格 :
美国375.00
克隆性 :
重组
宿主 :
domestic rabbit
共轭标签 :
未共轭
克隆名称 :
14H2L1
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 10
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 小鼠; 图 3a
  • 免疫细胞化学; 人类; 图 1f
Reyes J, Ekmark Lewén S, Perdiki M, Klingstedt T, Hoffmann A, Wiechec E, et al. Accumulation of alpha-synuclein within the liver, potential role in the clearance of brain pathology associated with Parkinson's disease. Acta Neuropathol Commun. 2021;9:46 pubmed 出版商
  • 免疫印迹; 人类; 1:1500
Lai Y, Kim S, Varkey J, Lou X, Song J, Diao J, et al. Nonaggregated ?-synuclein influences SNARE-dependent vesicle docking via membrane binding. Biochemistry. 2014;53:3889-96 pubmed 出版商
Moudio S, Rodin F, Albargothy N, Karlsson U, Reyes J, Hallbeck M. Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease. Front Neurol. 2022;13:826102 pubmed 出版商
Calamini B, Geyer N, Huss Braun N, Bernhardt A, Harsany V, Rival P, et al. Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2-driven Parkinson's disease. Dis Model Mech. 2021;14: pubmed 出版商
Schwab N, Grenier K, Hazrati L. DNA repair deficiency and senescence in concussed professional athletes involved in contact sports. Acta Neuropathol Commun. 2019;7:182 pubmed 出版商
Sackmann V, Sinha M, Sackmann C, Civitelli L, Bergström J, Ansell Schultz A, et al. Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia. Front Mol Neurosci. 2019;12:200 pubmed 出版商
Gorecki A, Preskey L, Bakeberg M, Kenna J, Gildenhuys C, MacDougall G, et al. Altered Gut Microbiome in Parkinson's Disease and the Influence of Lipopolysaccharide in a Human α-Synuclein Over-Expressing Mouse Model. Front Neurosci. 2019;13:839 pubmed 出版商
Schwab N, Tator C, Hazrati L. DNA damage as a marker of brain damage in individuals with history of concussions. Lab Invest. 2019;: pubmed 出版商
Höllerhage M, Moebius C, Melms J, Chiu W, Goebel J, Chakroun T, et al. Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells. Sci Rep. 2017;7:11469 pubmed 出版商
Coelho Cerqueira E, Carmo Gonçalves P, Pinheiro A, Cortines J, Follmer C. ?-Synuclein as an intrinsically disordered monomer--fact or artefact?. FEBS J. 2013;280:4915-27 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
alpha突触核蛋白重组兔单克隆抗体(14H2L1)
目录# :
701085
规格 :
100微克
价格 :
美国375.00
克隆性 :
重组单克隆
纯度 :
蛋白质A
宿主 :
兔
反应物种 :
人类
应用 :
Immunocytochemistry: 1:500-1:5,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:5,000
物种 :
人类
克隆 :
14H2L1
抗体亚型 :
IgG
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
免疫原 :
Peptide corresponding to amino acids 117-125 of human synuclein, alpha
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:500-1:5,000, Immunohistochemistry (Paraffin): 1:100-1:1,000, Western Blot: 1:500-1:5,000
别名 :
Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国