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抗体

SHP-1重组兔单克隆抗体(3H20L13)

703568

100微克

美国325.00

重组

domestic rabbit

未共轭

3H20L13

免疫印迹, 免疫细胞化学

SHP-1重组兔单克隆抗体(3H20L13)

703568

100微克

美国325.00

重组单克隆

蛋白质A

兔

人类

Immunocytochemistry: 1:100, Western Blot: 1:5,000

人类

3H20L13

IgG

短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.

Protein corresponding to human SHP-1 [aa243-aa541]

液体

Immunocytochemistry: 1:100, Western Blot: 1:5,000

70Z-SHP; EC 3.1.3.48; hcp; Hcph; hematopoietic cell phosphatase; hematopoietic cell protein-tyrosine phosphatase; HPTP1C; me; motheaten; protein tyrosine phosphatase, non-receptor type 6; protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; Ptp1C; PTP-1C; Ptph6; PTPN6; PTPTY-42; SH2 phosphatase 1; SHP1; Shp-1; SHP-1L; SH-PTP1; Tyrosine-protein phosphatase non-receptor type 6