产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
ZO-2多克隆抗体
目录 :
71-1400
规格 :
100微克
价格 :
美国439
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 犬
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, proximity ligation assay
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 21
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 3s2a
Fearnley G, Young K, Edgar J, Antrobus R, Hay I, Liang W, et al. The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion. elife. 2019;8: pubmed 出版商
  • proximity ligation assay; 犬; 1:100
  • 免疫细胞化学; 犬; 1:100; 图 1a
  • 免疫印迹; 犬; 1:1000; 图 1a
Raya Sandino A, Castillo Kauil A, Domínguez Calderón A, Alarcón L, Flores Benitez D, Cuellar Perez F, et al. Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function. Biochim Biophys Acta Mol Cell Res. 2017;1864:1714-1733 pubmed 出版商
  • 免疫细胞化学; 犬; 图 1A
Domínguez Calderón A, Ávila Flores A, Ponce A, López Bayghen E, Calderón Salinas J, Luis Reyes J, et al. ZO-2 silencing induces renal hypertrophy through a cell cycle mechanism and the activation of YAP and the mTOR pathway. Mol Biol Cell. 2016;27:1581-95 pubmed 出版商
Bhargavan B, Woollard S, McMillan J, Kanmogne G. CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice. Mol Neurodegener. 2021;16:78 pubmed 出版商
Hern xe1 ndez Guzm xe1 n C, Gallego Guti xe9 rrez H, Ch xe1 vez Mungu xed a B, Mart xed n Tapia D, Gonz xe1 lez Mariscal L. Zonula occludens 2 and Cell-Cell Contacts Are Required for Normal Nuclear Shape in Epithelia. Cells. 2021;10: pubmed 出版商
Ren Z, Pan L, Huang Y, Chen H, Liu Y, Liu H, et al. Gut microbiota-CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten-induced enteropathy. EMBO Mol Med. 2021;13:e14059 pubmed 出版商
Gallego Gutiérrez H, González González L, Ramírez Martínez L, Lopez Bayghen E, Gonzalez Mariscal L. Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD. Mol Biol Cell. 2021;32:1347-1358 pubmed 出版商
Thomsen M, Humle N, Hede E, Moos T, Burkhart A, Thomsen L. The blood-brain barrier studied in vitro across species. PLoS ONE. 2021;16:e0236770 pubmed 出版商
Bai H, Zhou R, Barravecchia M, Norman R, Friedman A, Yu D, et al. The Na+, K+-ATPase β1 subunit regulates epithelial tight junctions via MRCKα. JCI Insight. 2021;6: pubmed 出版商
Dai W, Nadadur R, Brennan J, Smith H, Shen K, Gadek M, et al. ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction. Circ Res. 2020;127:e28-e43 pubmed 出版商
Miranda J, Martín Tapia D, Valdespino Vazquez Y, Alarcón L, Espejel Nuñez A, Guzmán Huerta M, et al. Syncytiotrophoblast of Placentae from Women with Zika Virus Infection Has Altered Tight Junction Protein Expression and Increased Paracellular Permeability. Cells. 2019;8: pubmed 出版商
Amaya E, Alarcón L, Martín Tapia D, Cuellar Perez F, Cano Cortina M, Ortega Olvera J, et al. Activation of the Ca2+ sensing receptor and the PKC/WNK4 downstream signaling cascade induces incorporation of ZO-2 to tight junctions and its separation from 14-3-3. Mol Biol Cell. 2019;30:2377-2398 pubmed 出版商
García Aguirre I, Alamillo Iniesta A, Rodríguez Pérez R, Vélez Aguilera G, Amaro Encarnación E, Jiménez Gutiérrez E, et al. Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity. Aging Cell. 2019;18:e13002 pubmed 出版商
Li F, Pascal L, Stolz D, Wang K, Zhou Y, Chen W, et al. E-cadherin is downregulated in benign prostatic hyperplasia and required for tight junction formation and permeability barrier in the prostatic epithelial cell monolayer. Prostate. 2019;79:1226-1237 pubmed 出版商
Hsieh J, Rathore A, Soundarajan G, St John A. Japanese encephalitis virus neuropenetrance is driven by mast cell chymase. Nat Commun. 2019;10:706 pubmed 出版商
Rodríguez Uribe G, Serafín Higuera N, Damian Morales G, Cortés Malagón E, García Hernández V, Verdejo Torres O, et al. HPV16-E6 Oncoprotein Activates TGF-β and Wnt/β-Catenin Pathways in the Epithelium-Mesenchymal Transition of Cataracts in a Transgenic Mouse Model. Biomed Res Int. 2018;2018:2847873 pubmed 出版商
Bilal S, Jaggi S, Janosevic D, Shah N, Teymour S, Voronina A, et al. ZO-1 protein is required for hydrogen peroxide to increase MDCK cell paracellular permeability in an ERK 1/2-dependent manner. Am J Physiol Cell Physiol. 2018;315:C422-C431 pubmed 出版商
Cheng Y, Desse S, Martinez A, Worthen R, Jope R, Beurel E. TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice. Brain Behav Immun. 2018;69:556-567 pubmed 出版商
Tello Lafoz M, Martínez Martínez G, Rodríguez Rodríguez C, Albar J, Huse M, Gharbi S, et al. Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse. Traffic. 2017;18:491-504 pubmed 出版商
Martínez Revollar G, Garay E, Martín Tapia D, Nava P, Huerta M, Lopez Bayghen E, et al. Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways. Exp Cell Res. 2015;339:67-80 pubmed 出版商
Watari A, Hashegawa M, Yagi K, Kondoh M. Homoharringtonine increases intestinal epithelial permeability by modulating specific claudin isoforms in Caco-2 cell monolayers. Eur J Pharm Biopharm. 2015;89:232-8 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
ZO-2多克隆抗体
目录# :
71-1400
规格 :
100微克
定价 :
美国439
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
狗, 人类, 小鼠
应用 :
ELISA: Assay-dependent, Immunocytochemistry: 1 µg/mL, Immunohistochemistry: Assay-dependent, Western Blot: 1-2 µg/mL
物种 :
狗, 人类, 小鼠
抗体亚型 :
IgG
储存 :
-20°C
描述 :
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.
免疫原 :
Synthetic peptide derived from the central portion of the ZO-2 protein.
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Immunocytochemistry: 1 µg/mL, Immunohistochemistry: Assay-dependent, Western Blot: 1-2 µg/mL
别名 :
C9DUPq21.11; DFNA51; DUP9q21.11; Friedreich ataxia region gene X104 (tight junction protein ZO-2); PFIC4; tight junction protein; tight junction protein 2; tight junction protein 2 (zona occludens 2); tight junction protein ZO-2; Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2); Tjp2; X104; ZO2; ZO-2; zona occludens 2; zona occludens protein 2; Zonula occludens protein 2
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国