产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化STAT5甲(Tyr694)多克隆抗体
目录 :
71-6900
规格 :
50微克
价格 :
美国500.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
抗原修饰 :
磷酸化
反应物种 :
人类, 小鼠, 大鼠, 牛, 家羊
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-自由浮动切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 14
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 4g
  • 免疫印迹; 小鼠; 1:1000; 图 4a
Barcus C, O Leary K, Brockman J, Rugowski D, Liu Y, Garcia N, et al. Elevated collagen-I augments tumor progressive signals, intravasation and metastasis of prolactin-induced estrogen receptor alpha positive mammary tumor cells. Breast Cancer Res. 2017;19:9 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Schauwecker S, Kim J, Licht J, Clevenger C. Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells. J Biol Chem. 2017;292:2237-2254 pubmed 出版商
  • 免疫印迹; 人类; 图 2c
Barcus C, Keely P, Eliceiri K, Schuler L. Prolactin signaling through focal adhesion complexes is amplified by stiff extracellular matrices in breast cancer cells. Oncotarget. 2016;7:48093-48106 pubmed 出版商
  • 免疫组化-自由浮动切片; 大鼠; 1:100
Moravcová S, ÄŒervená K, Pačesová D, Bendová Z. Identification of STAT3 and STAT5 proteins in the rat suprachiasmatic nucleus and the Day/Night difference in astrocytic STAT3 phosphorylation in response to lipopolysaccharide. J Neurosci Res. 2016;94:99-108 pubmed 出版商
Lu Y, Zhou T, Xu C, Wang R, Feng D, Li J, et al. Occludin is a target of Src kinase and promotes lipid secretion by binding to BTN1a1 and XOR. PLoS Biol. 2022;20:e3001518 pubmed 出版商
Hadzijusufovic E, Keller A, Berger D, Greiner G, Wingelhofer B, Witzeneder N, et al. STAT5 is Expressed in CD34+/CD38- Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms. Cancers (Basel). 2020;12: pubmed 出版商
Hackl M, Fürnsinn C, Schuh C, Krssak M, Carli F, Guerra S, et al. Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis. Nat Commun. 2019;10:2717 pubmed 出版商
de Araujo E, Erdogan F, Neubauer H, Meneksedag Erol D, Manaswiyoungkul P, Eram M, et al. Structural and functional consequences of the STAT5BN642H driver mutation. Nat Commun. 2019;10:2517 pubmed 出版商
Wu T, Yang J, Wang Y, Yu F, Liu B. Mycotoxin ochratoxin A disrupts renal development via a miR-731/prolactin receptor axis in zebrafish. Toxicol Res (Camb). 2016;5:519-529 pubmed 出版商
Pham H, Maurer B, Prchal Murphy M, Grausenburger R, Grundschober E, Javaheri T, et al. STAT5BN642H is a driver mutation for T cell neoplasia. J Clin Invest. 2017;: pubmed 出版商
Gillinder K, Tuckey H, Bell C, Magor G, Huang S, Ilsley M, et al. Direct targets of pSTAT5 signalling in erythropoiesis. PLoS ONE. 2017;12:e0180922 pubmed 出版商
Botbol Y, Patel B, Macian F. Common γ-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation. Autophagy. 2015;11:1864-77 pubmed 出版商
Moon P, Kim M, Oh H, Nam S, Han N, Jeong H, et al. Cysteine induces longitudinal bone growth in mice by upregulating IGF-I. Int J Mol Med. 2015;36:571-6 pubmed 出版商
Wang R, Vadlamudi R, Bagheri Yarmand R, Beuvink I, Hynes N, Kumar R. Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands. J Cell Biol. 2003;161:583-92 pubmed
产品信息
产品类型 :
抗体
产品名称 :
磷酸化STAT5甲(Tyr694)多克隆抗体
目录# :
71-6900
规格 :
50微克
价格 :
美国500.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
Bovine, Human, Mouse, Ovine, Rat
应用 :
ELISA: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry: Assay-dependent, Western Blot: Assay-dependent
物种 :
Bovine, Human, Mouse, Ovine, Rat
抗体亚型 :
IgG
储存 :
-20°C
描述 :
STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5 alpha is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of STAT5 alpha in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of STAT5 alpha is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells. STAT5 alpha, along with STAT5 beta, were identified in mouse. The amino acid sequences of STAT5 alpha and STAT5 beta show 96% sequence similarity, and both proteins are co expressed in most tissues in virgin and lactating mice. However, differential accumulation of STAT5 alpha and STAT5 beta mRNA has been reported for both muscle and mammary tissue. STAT5 alpha is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.
免疫原 :
Synthetic tyrosine-phosphorylated peptide encompassing the conserved C-terminal tyrosine phosphorylation site (Y694) of murine STAT5. This peptide is conserved in human, bovine, sheep, and rat STAT5 proteins
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry: Assay-dependent, Western Blot: Assay-dependent
别名 :
AA959963; mammary gland factor; mammary gland factor STAT5A; mammary gland factor; transcription factor; Mgf; Mpf; signal transducer and activator of transcription 5; signal transducer and activator of transcription 5a; signal transducer and activator of transcription factor 5A; STAT; STAT5; STAT5A; STAT5A, Mammary Gland Factor; STAT5A/MGF; STAT5B; STATA5
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国