产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
NMDAR2B多克隆抗体
目录 :
71-8600
规格 :
100微克
价格 :
美国430.00
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, domestic rabbit
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-冰冻切片, 抑制或激活实验
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 9
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 人类; 1:300; 图 3
Dong Y, Hsu F, Koziol White C, Stepanova V, Jude J, Gritsiuta A, et al. Functional NMDA receptors are expressed by human pulmonary artery smooth muscle cells. Sci Rep. 2021;11:8205 pubmed 出版商
  • 免疫印迹; 小鼠; 1:250; 图 3a
Haubrich J, Bernabo M, Nader K. Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation. elife. 2020;9: pubmed 出版商
  • 免疫印迹; 小鼠; 1:3000; 图 4
Frank R, Komiyama N, Ryan T, Zhu F, O Dell T, Grant S. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation. Nat Commun. 2016;7:11264 pubmed 出版商
  • 抑制或激活实验; 大鼠; 图 s2
Würdemann T, Kersten M, Tokay T, Guli X, Kober M, Rohde M, et al. Stereotactic injection of cerebrospinal fluid from anti-NMDA receptor encephalitis into rat dentate gyrus impairs NMDA receptor function. Brain Res. 2016;1633:10-18 pubmed 出版商
Ferrari E, Scheggia D, Zianni E, Italia M, Brumana M, Palazzolo L, et al. Rabphilin-3A as a novel target to reverse α-synuclein-induced synaptic loss in Parkinson's disease. Pharmacol Res. 2022;183:106375 pubmed 出版商
Franchini L, Stanic J, Ponzoni L, Mellone M, Carrano N, Musardo S, et al. Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition. iScience. 2019;19:927-939 pubmed 出版商
McKay S, Ryan T, McQueen J, Indersmitten T, Marwick K, Hasel P, et al. The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences. Cell Rep. 2018;25:841-851.e4 pubmed 出版商
Guo Y, Zhang W, Chen X, Fu J, Cheng W, Song D, et al. Timing-dependent LTP and LTD in mouse primary visual cortex following different visual deprivation models. PLoS ONE. 2017;12:e0176603 pubmed 出版商
Megill A, Tran T, Eldred K, Lee N, Wong P, HOE H, et al. Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease. J Neurosci. 2015;35:11346-57 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
NMDAR2B多克隆抗体
目录# :
71-8600
规格 :
100微克
价格 :
美国430.00
克隆性 :
多克隆
纯度 :
抗原亲和色谱
宿主 :
兔
反应物种 :
兔, 大鼠
应用 :
Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent
物种 :
兔, 大鼠
抗体亚型 :
IgG
储存 :
-20°C
描述 :
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer’s Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.
免疫原 :
Fusion protein including a 251 amino acid sequence from the N-terminal portion of the rat NMDAR 2B protein.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent
别名 :
AW490526; EIEE27; GluN2B; GluRepsilon2; glutamate [NMDA] receptor subunit epsilon-2; glutamate ionotropic receptor NMDA type subunit 2B; glutamate receptor; glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, NMDA2B; glutamate receptor, ionotropic, NMDA2B (epsilon 2); glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN 2B; GRIN2B; HGNC:4586; hNR 3; hNR3; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B; MGC142178; MGC142180; MRD6; Nmdar2b; NMDE2; NME2; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 2B; N-methyl-D-aspartate receptor subunit 3; NR2B; NR3
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国