产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD3 Monoclonal Antibody (UCHT1), Super Bright 780, eBioscience™
目录 :
78-0038-41
规格 :
25Tests
价格 :
美国163
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
UCHT1
反应物种 :
人类
应用 :
流式细胞仪
更多信息或购买 :
文章摘录数: 54
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 人类; 图 s2a
Scheper W, Kelderman S, Fanchi L, Linnemann C, Bendle G, de Rooij M, et al. Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers. Nat Med. 2019;25:89-94 pubmed 出版商
Papaioannou E, Yanez D, Ross S, Lau C, Solanki A, Chawda M, et al. Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulation. J Clin Invest. 2019;129:3153-3170 pubmed 出版商
Hill D, Pierson W, Bolland D, Mkindi C, Carr E, Wang J, et al. The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes. J Exp Med. 2019;: pubmed 出版商
Mielke L, Liao Y, Clemens E, Firth M, Duckworth B, Huang Q, et al. TCF-1 limits the formation of Tc17 cells via repression of the MAF-RORγt axis. J Exp Med. 2019;: pubmed 出版商
Fenwick C, Loredo Varela J, Joo V, Pellaton C, Farina A, Rajah N, et al. Tumor suppression of novel anti-PD-1 antibodies mediated through CD28 costimulatory pathway. J Exp Med. 2019;: pubmed 出版商
Hammerich L, Marron T, Upadhyay R, Svensson Arvelund J, Dhainaut M, Hussein S, et al. Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination. Nat Med. 2019;25:814-824 pubmed 出版商
Colin York H, Javanmardi Y, Skamrahl M, Kumari S, Chang V, Khuon S, et al. Cytoskeletal Control of Antigen-Dependent T Cell Activation. Cell Rep. 2019;26:3369-3379.e5 pubmed 出版商
Strecker J, Jones S, Koopal B, Schmid Burgk J, Zetsche B, Gao L, et al. Engineering of CRISPR-Cas12b for human genome editing. Nat Commun. 2019;10:212 pubmed 出版商
Mensali N, Dillard P, Hebeisen M, Lorenz S, Theodossiou T, Myhre M, et al. NK cells specifically TCR-dressed to kill cancer cells. EBioMedicine. 2019;40:106-117 pubmed 出版商
Fiore A, Ugel S, De Sanctis F, Sandri S, Fracasso G, Trovato R, et al. Induction of immunosuppressive functions and NF-κB by FLIP in monocytes. Nat Commun. 2018;9:5193 pubmed 出版商
Chee J, Watson M, Chopra A, Nguyen B, Cook A, Creaney J, et al. Tumour associated lymphocytes in the pleural effusions of patients with mesothelioma express high levels of inhibitory receptors. BMC Res Notes. 2018;11:864 pubmed 出版商
Guo J, Zhang Y, Li H, Chu H, Wang Q, Jiang S, et al. Intramembrane ionic protein-lipid interaction regulates integrin structure and function. PLoS Biol. 2018;16:e2006525 pubmed 出版商
Patel N, Vukmanovic Stejic M, Suárez Fariñas M, Chambers E, Sandhu D, Fuentes Duculan J, et al. Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen-Specific Challenge. J Infect Dis. 2018;218:S88-S98 pubmed 出版商
Pissani F, Schulte B, Eller M, Schultz B, Ratto Kim S, Marovich M, et al. Modulation of Vaccine-Induced CD4 T Cell Functional Profiles by Changes in Components of HIV Vaccine Regimens in Humans. J Virol. 2018;92: pubmed 出版商
Desimio M, Giuliani E, Ferraro A, Adorno G, Doria M. In Vitro Exposure to Prostratin but Not Bryostatin-1 Improves Natural Killer Cell Functions Including Killing of CD4+ T Cells Harboring Reactivated Human Immunodeficiency Virus. Front Immunol. 2018;9:1514 pubmed 出版商
Zhao M, Svensson M, Venken K, Chawla A, Liang S, Engel I, et al. Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70. Nat Commun. 2018;9:2627 pubmed 出版商
Porichis F, Hart M, Massa A, Everett H, Morou A, Richard J, et al. Immune Checkpoint Blockade Restores HIV-Specific CD4 T Cell Help for NK Cells. J Immunol. 2018;201:971-981 pubmed 出版商
Provine N, Binder B, FitzPatrick M, Schuch A, Garner L, Williamson K, et al. Unique and Common Features of Innate-Like Human Vδ2+ γδT Cells and Mucosal-Associated Invariant T Cells. Front Immunol. 2018;9:756 pubmed 出版商
Vadrevu S, Trbojević Akmačić I, Kossenkov A, Colomb F, Giron L, Anzurez A, et al. Frontline Science: Plasma and immunoglobulin G galactosylation associate with HIV persistence during antiretroviral therapy. J Leukoc Biol. 2018;104:461-471 pubmed 出版商
Murray L, Satti I, Meyerowitz J, Jones M, Willberg C, Ussher J, et al. Human Immunodeficiency Virus Infection Impairs Th1 and Th17 Mycobacterium tuberculosis-Specific T-Cell Responses. J Infect Dis. 2018;217:1782-1792 pubmed 出版商
Duggal N, Pollock R, Lazarus N, Harridge S, Lord J. Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood. Aging Cell. 2018;17: pubmed 出版商
Dillen C, Pinsker B, Marusina A, Merleev A, Farber O, Liu H, et al. Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection. J Clin Invest. 2018;128:1026-1042 pubmed 出版商
Rivino L, Le Bert N, Gill U, Kunasegaran K, Cheng Y, Tan D, et al. Hepatitis B virus-specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation. J Clin Invest. 2018;128:668-681 pubmed 出版商
Peled M, Tocheva A, Sandigursky S, Nayak S, Philips E, Nichols K, et al. Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor. Proc Natl Acad Sci U S A. 2018;115:E468-E477 pubmed 出版商
Simons L, Ma K, de Chappedelaine C, Moiranghtem R, Elkaim E, Olivré J, et al. Generation of adult human T-cell progenitors for immunotherapeutic applications. J Allergy Clin Immunol. 2018;141:1491-1494.e4 pubmed 出版商
Schulten V, Tripple V, Seumois G, Qian Y, Scheuermann R, Fu Z, et al. Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells. J Allergy Clin Immunol. 2018;141:775-777.e6 pubmed 出版商
Roux C, Saviane G, Pini J, Belaïd N, Dhib G, Voha C, et al. Immunosuppressive Mesenchymal Stromal Cells Derived from Human-Induced Pluripotent Stem Cells Induce Human Regulatory T Cells In Vitro and In Vivo. Front Immunol. 2017;8:1991 pubmed 出版商
Seu L, Tidwell C, Timares L, Duverger A, Wagner F, Goepfert P, et al. CD151 Expression Is Associated with a Hyperproliferative T Cell Phenotype. J Immunol. 2017;199:3336-3347 pubmed 出版商
Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Hayashi T, Nakachi K, et al. Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol. 2017;199:2777-2793 pubmed 出版商
Dusséaux M, Masse Ranson G, Darche S, Ahodantin J, Li Y, Fiquet O, et al. Viral Load Affects the Immune Response to HBV in Mice With Humanized Immune System and Liver. Gastroenterology. 2017;153:1647-1661.e9 pubmed 出版商
Dillon S, Castleman M, Frank D, Austin G, Gianella S, Cogswell A, et al. Brief Report: Inflammatory Colonic Innate Lymphoid Cells Are Increased During Untreated HIV-1 Infection and Associated With Markers of Gut Dysbiosis and Mucosal Immune Activation. J Acquir Immune Defic Syndr. 2017;76:431-437 pubmed 出版商
Hegazy A, West N, Stubbington M, Wendt E, Suijker K, Datsi A, et al. Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation. Gastroenterology. 2017;153:1320-1337.e16 pubmed 出版商
Horwitz J, Bar On Y, Lu C, Fera D, Lockhart A, Lorenzi J, et al. Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo. Cell. 2017;170:637-648.e10 pubmed 出版商
van den Broek T, Madi A, Delemarre E, Schadenberg A, Tesselaar K, Borghans J, et al. Human neonatal thymectomy induces altered B-cell responses and autoreactivity. Eur J Immunol. 2017;47:1970-1981 pubmed 出版商
Li L, Guo X, Shi X, Li C, Wu W, Yan C, et al. Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling. Proc Natl Acad Sci U S A. 2017;114:E5891-E5899 pubmed 出版商
Miller S, Miles B, Guo K, Folkvord J, Meditz A, McCarter M, et al. Follicular Regulatory T Cells Are Highly Permissive to R5-Tropic HIV-1. J Virol. 2017;91: pubmed 出版商
Fløe A, Løppke C, Hilberg O, Wejse C, Brix L, Jacobsen K. Development of an epitope panel for consistent identification of antigen-specific T-cells in humans. Immunology. 2017;152:298-307 pubmed 出版商
Wadkin J, Patten D, Kamarajah S, Shepherd E, Novitskaya V, Berditchevski F, et al. CD151 supports VCAM-1-mediated lymphocyte adhesion to liver endothelium and is upregulated in chronic liver disease and hepatocellular carcinoma. Am J Physiol Gastrointest Liver Physiol. 2017;313:G138-G149 pubmed 出版商
Buranapraditkun S, Pissani F, Teigler J, Schultz B, Alter G, Marovich M, et al. Preservation of Peripheral T Follicular Helper Cell Function in HIV Controllers. J Virol. 2017;91: pubmed 出版商
Nouri Shirazi M, Bible B, Zeng M, Tamjidi S, Bossart G. Phenotyping and comparing the immune cell populations of free-ranging Atlantic bottlenose dolphins (Tursiops truncatus) and dolphins under human care. BMC Vet Res. 2017;13:78 pubmed 出版商
Restorick S, Durant L, Kalra S, Hassan Smith G, Rathbone E, Douglas M, et al. CCR6+ Th cells in the cerebrospinal fluid of persons with multiple sclerosis are dominated by pathogenic non-classic Th1 cells and GM-CSF-only-secreting Th cells. Brain Behav Immun. 2017;64:71-79 pubmed 出版商
Tyler C, McCarthy N, Lindsay J, Stagg A, Moser B, Eberl M. Antigen-Presenting Human γδ T Cells Promote Intestinal CD4+ T Cell Expression of IL-22 and Mucosal Release of Calprotectin. J Immunol. 2017;198:3417-3425 pubmed 出版商
Weinacht K, Charbonnier L, Alroqi F, Plant A, Qiao Q, Wu H, et al. Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation. J Allergy Clin Immunol. 2017;139:1629-1640.e2 pubmed 出版商
Aw Yeang H, Piersma S, Lin Y, Yang L, Malkova O, Miner C, et al. Cutting Edge: Human CD49e- NK Cells Are Tissue Resident in the Liver. J Immunol. 2017;198:1417-1422 pubmed 出版商
Ribeiro S, Tesio M, Ribot J, Macintyre E, Barata J, Silva Santos B. Casein kinase 2 controls the survival of normal thymic and leukemic ?? T cells via promotion of AKT signaling. Leukemia. 2017;31:1603-1610 pubmed 出版商
Cheeseman H, Olejniczak N, Rogers P, Evans A, King D, Ziprin P, et al. Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies. J Virol. 2017;91: pubmed 出版商
Chen H, Händel N, Ngeow J, Muller J, Huhn M, Yang H, et al. Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells. J Allergy Clin Immunol. 2017;139:607-620.e15 pubmed 出版商
Amicarella F, Muraro M, Hirt C, Cremonesi E, Padovan E, Mele V, et al. Dual role of tumour-infiltrating T helper 17 cells in human colorectal cancer. Gut. 2017;66:692-704 pubmed 出版商
Yi J, Manna A, Barr V, Hong J, Neuman K, Samelson L. madSTORM: a superresolution technique for large-scale multiplexing at single-molecule accuracy. Mol Biol Cell. 2016;27:3591-3600 pubmed
Perdu S, Castellana B, Kim Y, Chan K, DeLuca L, Beristain A. Maternal obesity drives functional alterations in uterine NK cells. JCI Insight. 2016;1:e85560 pubmed 出版商
Bertin S, Aoki Nonaka Y, de Jong P, Nohara L, Xu H, Stanwood S, et al. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4? T cells. Nat Immunol. 2014;15:1055-1063 pubmed 出版商
Viglietta V, Baecher Allan C, Weiner H, Hafler D. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med. 2004;199:971-9 pubmed
Bunnell S, Hong D, Kardon J, Yamazaki T, McGlade C, Barr V, et al. T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J Cell Biol. 2002;158:1263-75 pubmed
Kirchgessner H, Dietrich J, Scherer J, Isomaki P, Korinek V, Hilgert I, et al. The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J Exp Med. 2001;193:1269-84 pubmed
产品信息
产品类型 :
抗体
产品名称 :
CD3 Monoclonal Antibody (UCHT1), Super Bright 780, eBioscience™
目录# :
78-0038-41
规格 :
25Tests
价格 :
美国163
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 5 µL (0.5 µg)/test
物种 :
人类
克隆 :
UCHT1
抗体亚型 :
IgG1, kappa
储存 :
4° C, store in dark, DO NOT FREEZE!
描述 :
The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 5 µL (0.5 µg)/test
别名 :
HCD3
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国