产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
OxPhos Complex IV subunit IV Monoclonal Antibody (10G8D12C12)
目录 :
A-21347
规格 :
100微克
价格 :
美国339.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
10G8D12C12
反应物种 :
仓鼠, 人类, 小鼠, 大鼠, , 猕猴
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 45
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 3b
Moren C, Gonzalez Casacuberta I, Alvarez Fernández C, Bano M, Catalán García M, Guitart Mampel M, et al. HIV-1 promonocytic and lymphoid cell lines: an in vitro model of in vivo mitochondrial and apoptotic lesion. J Cell Mol Med. 2017;21:402-409 pubmed 出版商
  • 免疫印迹; 人类; 1:5000; 图 2b
Reed G, Schiller G, Kambhampati S, Tallman M, Douer D, Minden M, et al. A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia. Cancer Med. 2016;5:3031-3040 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 5c
Wei R, Lin S, Wu W, Chen L, Li C, Chen H, et al. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016;311:88-98 pubmed 出版商
  • 免疫印迹; 人类; 图 3c
Maughan R, Feeney E, Capel E, Capeau J, Domingo P, Giralt M, et al. Improved adipose tissue function with initiation of protease inhibitor-only ART. J Antimicrob Chemother. 2016;71:3212-3221 pubmed
  • 免疫印迹; 人类; 图 5
Scott A, Wilkinson A, Wilkinson J. Basal metabolic state governs AIF-dependent growth support in pancreatic cancer cells. BMC Cancer. 2016;16:286 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, et al. Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA. Autophagy. 2015;11:1623-35 pubmed 出版商
  • 免疫印迹; 人类
Kim T, Kim J, Kim Z, Huang R, Chae Y, Wang R. Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive ox. BMC Complement Altern Med. 2014;14:236 pubmed 出版商
  • 免疫印迹; 大鼠; 图 6
Smith B, Perry C, Herbst E, Ritchie I, Beaudoin M, Smith J, et al. Submaximal ADP-stimulated respiration is impaired in ZDF rats and recovered by resveratrol. J Physiol. 2013;591:6089-101 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Lewis E, Wilkinson A, Jackson J, Mehra R, Varambally S, Chinnaiyan A, et al. The enzymatic activity of apoptosis-inducing factor supports energy metabolism benefiting the growth and invasiveness of advanced prostate cancer cells. J Biol Chem. 2012;287:43862-75 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 7
Kuo K, Chen Y, Chen L, Li C, Lan Y, Chang F, et al. Involvement of phorbol-12-myristate-13-acetate-induced protein 1 in goniothalamin-induced TP53-dependent and -independent apoptosis in hepatocellular carcinoma-derived cells. Toxicol Appl Pharmacol. 2011;256:8-23 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Kim J, Yu S, Oh H, Lee J, Kim Y, Sohn J. Panaxydol induces apoptosis through an increased intracellular calcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species. Apoptosis. 2011;16:347-58 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Hou W, Han J, Lu C, Goldstein L, Rabinowich H. Autophagic degradation of active caspase-8: a crosstalk mechanism between autophagy and apoptosis. Autophagy. 2010;6:891-900 pubmed 出版商
  • 免疫印迹; 大鼠; 图 1
McConell G, Ng G, Phillips M, Ruan Z, Macaulay S, Wadley G. Central role of nitric oxide synthase in AICAR and caffeine-induced mitochondrial biogenesis in L6 myocytes. J Appl Physiol (1985). 2010;108:589-95 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Garibal J, Hollville E, Renouf B, Tétaud C, Wiels J. Caspase-8-mediated cleavage of Bid and protein phosphatase 2A-mediated activation of Bax are necessary for Verotoxin-1-induced apoptosis in Burkitt's lymphoma cells. Cell Signal. 2010;22:467-75 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Kutuk O, Arisan E, Tezil T, Shoshan M, Basaga H. Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation. Carcinogenesis. 2009;30:1517-27 pubmed 出版商
  • 免疫印迹; 人类
Yee K, Wilkinson S, James J, Ryan K, Vousden K. PUMA- and Bax-induced autophagy contributes to apoptosis. Cell Death Differ. 2009;16:1135-45 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Trougakos I, Lourda M, Antonelou M, Kletsas D, Gorgoulis V, Papassideri I, et al. Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex. Clin Cancer Res. 2009;15:48-59 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Sibayama Imazu T, Fujisawa Y, Masuda Y, Aiuchi T, Nakajo S, Itabe H, et al. Induction of apoptosis in PA-1 ovarian cancer cells by vitamin K2 is associated with an increase in the level of TR3/Nur77 and its accumulation in mitochondria and nuclei. J Cancer Res Clin Oncol. 2008;134:803-12 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 2
Castello P, Drechsel D, Day B, Patel M. Inhibition of mitochondrial hydrogen peroxide production by lipophilic metalloporphyrins. J Pharmacol Exp Ther. 2008;324:970-6 pubmed
  • 免疫印迹; 人类; 图 4c
Yee K, Vousden K. Contribution of membrane localization to the apoptotic activity of PUMA. Apoptosis. 2008;13:87-95 pubmed
  • 免疫印迹; 人类; 图 3
Autret A, Martin Latil S, Mousson L, Wirotius A, Petit F, Arnoult D, et al. Poliovirus induces Bax-dependent cell death mediated by c-Jun NH2-terminal kinase. J Virol. 2007;81:7504-16 pubmed
  • 免疫印迹; 大鼠; 1:1000
Castello P, Drechsel D, Patel M. Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain. J Biol Chem. 2007;282:14186-93 pubmed
  • 免疫印迹; 猕猴
Martin Latil S, Mousson L, Autret A, Colbere Garapin F, Blondel B. Bax is activated during rotavirus-induced apoptosis through the mitochondrial pathway. J Virol. 2007;81:4457-64 pubmed
  • 免疫印迹; 大鼠; 1:20,000
Brown M, Sullivan P, Geddes J. Synaptic mitochondria are more susceptible to Ca2+overload than nonsynaptic mitochondria. J Biol Chem. 2006;281:11658-68 pubmed
  • 免疫印迹; 人类; 图 1
Iuso A, Scacco S, Piccoli C, Bellomo F, Petruzzella V, Trentadue R, et al. Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I. J Biol Chem. 2006;281:10374-80 pubmed
  • 免疫印迹; 大鼠; 1:1000; 图 6A
Ishihara Y, Shimamoto N. Involvement of endonuclease G in nucleosomal DNA fragmentation under sustained endogenous oxidative stress. J Biol Chem. 2006;281:6726-33 pubmed
  • 免疫印迹; 人类; 图 4
Boehning D, van Rossum D, Patterson R, Snyder S. A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways. Proc Natl Acad Sci U S A. 2005;102:1466-71 pubmed
  • 免疫组化-石蜡切片; 小鼠; 1:100; 图 2
Plesnila N, Zhu C, Culmsee C, Gröger M, Moskowitz M, Blomgren K. Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia. J Cereb Blood Flow Metab. 2004;24:458-66 pubmed
  • 免疫印迹; 小鼠; 图 1b
Lustbader J, Cirilli M, Lin C, Xu H, Takuma K, Wang N, et al. ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science. 2004;304:448-52 pubmed
  • 免疫细胞化学; 人类; 图 4
Thomenius M, Wang N, Reineks E, Wang Z, Distelhorst C. Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3-only proteins. J Biol Chem. 2003;278:6243-50 pubmed
  • 免疫组化-石蜡切片; 大鼠; 1:200; 图 1
Walzel B, Speer O, Zanolla E, Eriksson O, Bernardi P, Wallimann T. Novel mitochondrial creatine transport activity. Implications for intracellular creatine compartments and bioenergetics. J Biol Chem. 2002;277:37503-11 pubmed
  • 免疫细胞化学; 仓鼠; 图 2
Pan Z, Bhat M, Nieminen A, Ma J. Synergistic movements of Ca(2+) and Bax in cells undergoing apoptosis. J Biol Chem. 2001;276:32257-63 pubmed
  • 免疫组化-冰冻切片; 人类; 1:100; 图 2
Tanji K, Bonilla E. Optical imaging techniques (histochemical, immunohistochemical, and in situ hybridization staining methods) to visualize mitochondria. Methods Cell Biol. 2001;65:311-32 pubmed
  • 免疫印迹; 人类
Griffiths G, Dubrez L, Morgan C, Jones N, Whitehouse J, Corfe B, et al. Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis. J Cell Biol. 1999;144:903-14 pubmed
  • 免疫印迹; 人类; 1 ug/ml; 图 4
Marusich M, Robinson B, Taanman J, Kim S, Schillace R, Smith J, et al. Expression of mtDNA and nDNA encoded respiratory chain proteins in chemically and genetically-derived Rho0 human fibroblasts: a comparison of subunit proteins in normal fibroblasts treated with ethidium bromide and fibroblasts from a patient with mtD. Biochim Biophys Acta. 1997;1362:145-59 pubmed
  • 免疫印迹; 人类; 图 1
Taanman J, Burton M, Marusich M, Kennaway N, Capaldi R. Subunit specific monoclonal antibodies show different steady-state levels of various cytochrome-c oxidase subunits in chronic progressive external ophthalmoplegia. Biochim Biophys Acta. 1996;1315:199-207 pubmed
  • 免疫印迹; 牛; 图 3
  • 免疫印迹; 人类; 图 3
Capaldi R, Marusich M, Taanman J. Mammalian cytochrome-c oxidase: characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells. Methods Enzymol. 1995;260:117-32 pubmed
  • 免疫印迹; 大鼠
Nangaku M, Sato Yoshitake R, Okada Y, Noda Y, Takemura R, Yamazaki H, et al. KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell. 1994;79:1209-20 pubmed
Suh D, Park S, Jin H, Lee K, Bae J. LRIG2 is a growth suppressor of Hec-1A and Ishikawa endometrial adenocarcinoma cells by regulating PI3K/AKT- and EGFR-mediated apoptosis and cell-cycle. Oncogenesis. 2018;7:3 pubmed 出版商
Srinivasan S, Cesa L, Li X, Julien O, Zhuang M, Shao H, et al. Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades. Mol Cancer Res. 2018;16:58-68 pubmed 出版商
Nag T, Wadhwa S. Immunolocalisation pattern of complex I-V in ageing human retina: Correlation with mitochondrial ultrastructure. Mitochondrion. 2016;31:20-32 pubmed 出版商
Ripolone M, Ronchi D, Violano R, Vallejo D, Fagiolari G, Barca E, et al. Impaired Muscle Mitochondrial Biogenesis and Myogenesis in Spinal Muscular Atrophy. JAMA Neurol. 2015;72:666-75 pubmed 出版商
Kim T, Kim J, Kim Z, Huang R, Wang R. Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species. PLoS ONE. 2012;7:e46208 pubmed 出版商
Vitte J, Traver S, Maués De Paula A, Lesage S, Rovelli G, Corti O, et al. Leucine-rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease. J Neuropathol Exp Neurol. 2010;69:959-72 pubmed 出版商
Masuda Y, Shima G, Aiuchi T, Horie M, Hori K, Nakajo S, et al. Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. J Biol Chem. 2004;279:42503-15 pubmed
产品信息
产品类型 :
抗体
产品名称 :
OxPhos Complex IV subunit IV Monoclonal Antibody (10G8D12C12)
目录# :
A-21347
规格 :
100微克
价格 :
美国339.00
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
牛, 人类
应用 :
Immunohistochemistry (Paraffin): 1:20, Western Blot: 1.0 µg/mL
物种 :
牛, 人类
克隆 :
10G8D12C12
抗体亚型 :
IgG2a, kappa
储存 :
4° C
描述 :
Complex IV, also called cytochrome c oxidoreductase or cytochrome c oxidase, is a complex of 13 different subunits, three of which (I, II and III) are encoded on mitochondrial DNA and the remainder in the nuclear DNA. The complex contains two heme groups (a and a3) and two copper atoms as prosthetic groups.
免疫原 :
Bovine Complex IV subunit IV
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:20, Western Blot: 1.0 µg/mL
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国