产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
NMDAR2B多克隆抗体
目录 :
A-6474
规格 :
10µg
价格 :
美国459
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 3
出版应用/物种/样本/稀释参考文献
  • 免疫细胞化学; 大鼠; 1:500; 图 6a
Ampuero E, Jury N, Hartel S, Marzolo M, van Zundert B. Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons. J Cell Physiol. 2017;232:1187-1199 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Sceniak M, Lang M, Enomoto A, James Howell C, Hermes D, Katz D. Mechanisms of Functional Hypoconnectivity in the Medial Prefrontal Cortex of Mecp2 Null Mice. Cereb Cortex. 2016;26:1938-1956 pubmed 出版商
Ma Q, Ying M, Sui X, Zhang H, Huang H, Yang L, et al. Chronic copper exposure causes spatial memory impairment, selective loss of hippocampal synaptic proteins, and activation of PKR/eIF2α pathway in mice. J Alzheimers Dis. 2015;43:1413-27 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
NMDAR2B多克隆抗体
目录# :
A-6474
规格 :
10µg
价格 :
美国459
克隆性 :
多克隆
纯度 :
IgG分馏成分
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠
应用 :
ELISA: Assay Dependent, Immunofluorescence: 1:500-1:5000, Immunohistochemistry (Frozen): 1:500-1:5000, Immunoprecipitation: 3 µL, Western Blot: 1:100-1:500
物种 :
人类, 小鼠, 大鼠
抗体亚型 :
IgG
储存 :
-20°C
描述 :
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer’s Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.
免疫原 :
Fusion protein containing amino acid residues 984–1104 of the C-terminal region of rat brain subunit 2B
格式 :
冻干
应用w/稀释 :
ELISA: Assay Dependent, Immunofluorescence: 1:500-1:5000, Immunohistochemistry (Frozen): 1:500-1:5000, Immunoprecipitation: 3 µL, Western Blot: 1:100-1:500
别名 :
AW490526; BOS_5813; EIEE27; GluN2B; GluRepsilon2; Glutamate [NMDA] receptor subunit epsilon-2; glutamate ionotropic receptor NMDA type subunit 2B; glutamate receptor; Glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, NMDA2B; glutamate receptor, ionotropic, NMDA2B (epsilon 2); glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN 2B; Grin2b; HGNC:4586; hNR 3; hNR3; MGC142178; MGC142180; MRD6; NMDAR2B; NMDE2; NME2; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 2B; N-methyl-D-aspartate receptor subunit 3; NR2B; NR3
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国