产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (TAU-5)
目录 :
AHB0042
规格 :
100µg
价格 :
美国331
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
Tau-5
反应物种 :
人类, 小鼠, 大鼠, ,
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片, 免疫印迹基因敲除验证, 免疫细胞化学基因敲除验证
更多信息或购买 :
文章摘录数: 100
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000
Silva M, Ferguson F, Cai Q, Donovan K, Nandi G, Patnaik D, et al. Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. elife. 2019;8: pubmed 出版商
  • 免疫组化; 小鼠; 图 1c
Merezhko M, Brunello C, Yan X, Vihinen H, Jokitalo E, Uronen R, et al. Secretion of Tau via an Unconventional Non-vesicular Mechanism. Cell Rep. 2018;25:2027-2035.e4 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 8b
Quaranta V, Rainer C, Nielsen S, Raymant M, Ahmed M, Engle D, et al. Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer. Cancer Res. 2018;78:4253-4269 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 1a
Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2A
Chen S, Sun J, Zhao G, Guo A, Chen Y, Fu R, et al. Liraglutide Improves Water Maze Learning and Memory Performance While Reduces Hyperphosphorylation of Tau and Neurofilaments in APP/PS1/Tau Triple Transgenic Mice. Neurochem Res. 2017;42:2326-2335 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5a
Maphis N, Jiang S, Binder J, Wright C, Gopalan B, Lamb B, et al. Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology. Front Mol Neurosci. 2017;10:69 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:100; 图 2e
Li Y, Li Z, Jin T, Wang Z, Zhao P. Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases. J Alzheimers Dis. 2017;57:395-409 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 4b
Shin S, Kim J, Lee J, Son Y, Lee M, Kim H, et al. Docosahexaenoic acid-mediated protein aggregates may reduce proteasome activity and delay myotube degradation during muscle atrophy in vitro. Exp Mol Med. 2017;49:e287 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 7a
Takahashi H, Klein Z, Bhagat S, Kaufman A, Kostylev M, Ikezu T, et al. Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathol. 2017;133:785-807 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 1:1000; 图 4b
Van Hummel A, Bi M, Ippati S, van der Hoven J, Volkerling A, Lee W, et al. No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapttm1(EGFP)Kit GFP Knockin Mice. PLoS ONE. 2016;11:e0163236 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:1000; 图 s1a
Soo Hoo L, Banna C, Radeke C, Sharma N, Albertolle M, Low S, et al. The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons. PLoS ONE. 2016;11:e0163671 pubmed 出版商
  • 免疫细胞化学基因敲除验证; 小鼠; 图 3
  • 免疫细胞化学; 人类; 图 3
Mansuroglu Z, Benhelli Mokrani H, Marcato V, Sultan A, Violet M, Chauderlier A, et al. Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin. Sci Rep. 2016;6:33047 pubmed 出版商
  • 免疫印迹; 人类; 图 3d
Yoshitake J, Soeda Y, Ida T, Sumioka A, Yoshikawa M, Matsushita K, et al. Modification of Tau by 8-Nitroguanosine 3',5'-Cyclic Monophosphate (8-Nitro-cGMP): EFFECTS OF NITRIC OXIDE-LINKED CHEMICAL MODIFICATION ON TAU AGGREGATION. J Biol Chem. 2016;291:22714-22720 pubmed
  • 免疫印迹; 人类; 图 s3
Sohn P, Tracy T, Son H, Zhou Y, Leite R, Miller B, et al. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Mol Neurodegener. 2016;11:47 pubmed 出版商
  • 免疫细胞化学; 人类; 1:600; 图 4
  • 免疫印迹; 人类; 1:1000; 图 2
Yan X, Nykänen N, Brunello C, Haapasalo A, Hiltunen M, Uronen R, et al. FRMD4A-cytohesin signaling modulates the cellular release of tau. J Cell Sci. 2016;129:2003-15 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:500; 表 1
  • 免疫印迹; 小鼠; 1:500; 表 1
Krishnan V, White Z, McMahon C, Hodgetts S, Fitzgerald M, Shavlakadze T, et al. A Neurogenic Perspective of Sarcopenia: Time Course Study of Sciatic Nerves From Aging Mice. J Neuropathol Exp Neurol. 2016;75:464-78 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Ortuno D, Carlisle H, Miller S. Does inactivation of USP14 enhance degradation of proteasomal substrates that are associated with neurodegenerative diseases?. F1000Res. 2016;5:137 pubmed 出版商
  • 免疫印迹; 人类; 1:10,000; 图 3f
Choi W, de Poot S, Lee J, Kim J, Han D, Kim Y, et al. Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation. Nat Commun. 2016;7:10963 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Urnukhsaikhan E, Cho H, Mishig Ochir T, Seo Y, Park J. Pulsed electromagnetic fields promote survival and neuronal differentiation of human BM-MSCs. Life Sci. 2016;151:130-138 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Kailainathan S, Piers T, Yi J, Choi S, Fahey M, Borger E, et al. Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF). Pharmacol Res. 2016;104:97-107 pubmed 出版商
  • 免疫印迹; 人类; 1 mg/ml; 图 10
Puvenna V, Engeler M, Banjara M, Brennan C, Schreiber P, Dadas A, et al. Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy. Brain Res. 2016;1630:225-40 pubmed 出版商
  • 免疫印迹; 人类
de Paula C, Santiago F, de Oliveira A, Oliveira F, Almeida M, Carrettiero D. The Co-chaperone BAG2 Mediates Cold-Induced Accumulation of Phosphorylated Tau in SH-SY5Y Cells. Cell Mol Neurobiol. 2016;36:593-602 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 表 1
  • 免疫印迹; 人类; 1:1000; 表 1
Piedrahita D, Castro Álvarez J, Boudreau R, Villegas Lanau A, Kosik K, Gallego Gómez J, et al. β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice. Front Cell Neurosci. 2015;9:498 pubmed 出版商
  • 免疫印迹; 猫; 1:1000; 图 4
Chambers J, Tokuda T, Uchida K, Ishii R, Tatebe H, Takahashi E, et al. The domestic cat as a natural animal model of Alzheimer's disease. Acta Neuropathol Commun. 2015;3:78 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 5
Gyoneva S, Kim D, Katsumoto A, Kokiko Cochran O, Lamb B, Ransohoff R. Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury. J Neuroinflammation. 2015;12:228 pubmed 出版商
  • 免疫沉淀; 人类; 图 1
  • 免疫印迹; 人类; 图 1
Min S, Chen X, Tracy T, Li Y, Zhou Y, Wang C, et al. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nat Med. 2015;21:1154-62 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Sun L, Ban T, Liu C, Chen Q, Wang X, Yan M, et al. Activation of Cdk5/p25 and tau phosphorylation following chronic brain hypoperfusion in rats involves microRNA-195 down-regulation. J Neurochem. 2015;134:1139-51 pubmed 出版商
  • 免疫印迹; 人类; 1:5000; 图 1
Sheik Mohideen S, Yamasaki Y, Omata Y, Tsuda L, Yoshiike Y. Nontoxic singlet oxygen generator as a therapeutic candidate for treating tauopathies. Sci Rep. 2015;5:10821 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4
Petrov D, Pedrós I, Artiach G, Sureda F, Barroso E, Pallas M, et al. High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents. Biochim Biophys Acta. 2015;1852:1687-99 pubmed 出版商
  • 免疫印迹; 人类
De Zio D, Molinari F, Rizza S, Gatta L, Ciotti M, Salvatore A, et al. Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth. Cell Mol Life Sci. 2015;72:4173-91 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 图 2
  • 免疫印迹; 人类; 1:1000; 图 4
Ohia Nwoko O, Montazari S, Lau Y, Eriksen J. Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice. Mol Neurodegener. 2014;9:54 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Castro Alvarez J, Uribe Arias S, Kosik K, Cardona Gómez G. Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice. Front Aging Neurosci. 2014;6:243 pubmed 出版商
  • 免疫印迹; 小鼠; 1:20000
Lee S, Xu G, Jay T, Bhatta S, Kim K, Jung S, et al. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. J Neurosci. 2014;34:12538-46 pubmed 出版商
  • 免疫组化; 小鼠; 1:3000
Gheyara A, Ponnusamy R, Djukic B, Craft R, Ho K, Guo W, et al. Tau reduction prevents disease in a mouse model of Dravet syndrome. Ann Neurol. 2014;76:443-56 pubmed 出版商
  • 免疫印迹; 小鼠
Pedr s I, Petrov D, Allgaier M, Sureda F, Barroso E, Beas Zarate C, et al. Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease. Biochim Biophys Acta. 2014;1842:1556-66 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Liu X, Zhou J, Abid M, Yan H, Huang H, Wan L, et al. Berberine attenuates axonal transport impairment and axonopathy induced by Calyculin A in N2a cells. PLoS ONE. 2014;9:e93974 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Liu C, Götz J. Profiling murine tau with 0N, 1N and 2N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus. PLoS ONE. 2013;8:e84849 pubmed 出版商
  • 免疫印迹; 小鼠; 1:4000
Notter T, Panzanelli P, PFISTER S, Mircsof D, Fritschy J. A protocol for concurrent high-quality immunohistochemical and biochemical analyses in adult mouse central nervous system. Eur J Neurosci. 2014;39:165-75 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠
Manich G, del Valle J, Cabezón I, Camins A, Pallas M, Pelegri C, et al. Presence of a neo-epitope and absence of amyloid beta and tau protein in degenerative hippocampal granules of aged mice. Age (Dordr). 2014;36:151-65 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Ordóñez Gutiérrez L, Torres J, Gavin R, Anton M, Arroba Espinosa A, Espinosa J, et al. Cellular prion protein modulates ?-amyloid deposition in aged APP/PS1 transgenic mice. Neurobiol Aging. 2013;34:2793-804 pubmed 出版商
  • 免疫组化; 人类; 1:1000
  • 免疫印迹; 人类; 1:1000; 图 3
Hebron M, Algarzae N, Lonskaya I, Moussa C. Fractalkine signaling and Tau hyper-phosphorylation are associated with autophagic alterations in lentiviral Tau and A?1-42 gene transfer models. Exp Neurol. 2014;251:127-38 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 6
Porquet D, Casadesus G, Bayod S, Vicente A, Canudas A, Vilaplana J, et al. Dietary resveratrol prevents Alzheimer's markers and increases life span in SAMP8. Age (Dordr). 2013;35:1851-65 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3
Tian M, Zhu D, Xie W, Shi J. Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains. FEBS Lett. 2012;586:3737-45 pubmed 出版商
  • 免疫组化; 大鼠; 1:2000
Karlsson O, Berg A, Lindström A, Hanrieder J, Arnerup G, Roman E, et al. Neonatal exposure to the cyanobacterial toxin BMAA induces changes in protein expression and neurodegeneration in adult hippocampus. Toxicol Sci. 2012;130:391-404 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Sontag J, Nunbhakdi Craig V, White C, Halpain S, Sontag E. The protein phosphatase PP2A/B? binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies. J Biol Chem. 2012;287:14984-93 pubmed 出版商
  • 免疫组化; 小鼠; 图 3
Kaul T, Credle J, Haggerty T, Oaks A, Masliah E, Sidhu A. Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease. BMC Neurosci. 2011;12:79 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2
Maldonado H, Ramírez E, Utreras E, Pando M, Kettlun A, Chiong M, et al. Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-β prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes. J Neurosci Res. 2011;89:1489-98 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 2
Haggerty T, Credle J, Rodriguez O, Wills J, Oaks A, Masliah E, et al. Hyperphosphorylated Tau in an ?-synuclein-overexpressing transgenic model of Parkinson's disease. Eur J Neurosci. 2011;33:1598-610 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500; 图 3
Wills J, Credle J, Haggerty T, Lee J, Oaks A, Sidhu A. Tauopathic changes in the striatum of A53T ?-synuclein mutant mouse model of Parkinson's disease. PLoS ONE. 2011;6:e17953 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:1000; 图 5
  • 免疫印迹; 大鼠; 1:2000; 图 4
Nakajima T, Ochi S, Oda C, Ishii M, Ogawa K. Ischemic preconditioning attenuates of ischemia-induced degradation of spectrin and tau: implications for ischemic tolerance. Neurol Sci. 2011;32:229-39 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Spatara M, Robinson A. Transgenic mouse and cell culture models demonstrate a lack of mechanistic connection between endoplasmic reticulum stress and tau dysfunction. J Neurosci Res. 2010;88:1951-61 pubmed 出版商
  • 酶联免疫吸附测定; 人类; 图 1a
Hall E, Lee S, Mairuae N, Simmons Z, Connor J. Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues. Neurobiol Aging. 2011;32:1409-19 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 3
Kim H, Sul D, Lim J, Lee D, Joo S, Hwang K, et al. Delphinidin ameliorates beta-amyloid-induced neurotoxicity by inhibiting calcium influx and tau hyperphosphorylation. Biosci Biotechnol Biochem. 2009;73:1685-9 pubmed
  • 免疫印迹; 大鼠; 1:1000
Sul D, Kim H, Lee D, Joo S, Hwang K, Park S. Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation. Life Sci. 2009;84:257-62 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Sul D, Kim H, Cho E, Lee M, Kim H, Jung W, et al. 2,3,7,8-TCDD neurotoxicity in neuroblastoma cells is caused by increased oxidative stress, intracellular calcium levels, and tau phosphorylation. Toxicology. 2009;255:65-71 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 6
Park S, Kim H, Cho E, Kwon B, Phark S, Hwang K, et al. Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation. Food Chem Toxicol. 2008;46:2881-7 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Fukuzaki E, Takuma K, Himeno Y, Yoshida S, Funatsu Y, Kitahara Y, et al. Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits. Neurosci Lett. 2008;433:141-5 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5
Liu R, Zhou X, Tanila H, Bjorkdahl C, Wang J, Guan Z, et al. Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology. J Cell Mol Med. 2008;12:241-57 pubmed 出版商
  • 免疫印迹; 大鼠; 1:5000
Selenica M, Jensen H, Larsen A, Pedersen M, Helboe L, Leist M, et al. Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation. Br J Pharmacol. 2007;152:959-79 pubmed
  • 免疫组化-冰冻切片; 人类; 1:500
  • 免疫印迹; 人类; 1:500
Bai Q, Garver J, Hukriede N, Burton E. Generation of a transgenic zebrafish model of Tauopathy using a novel promoter element derived from the zebrafish eno2 gene. Nucleic Acids Res. 2007;35:6501-16 pubmed
  • 免疫印迹; 小鼠; 图 4
Jossin Y, Goffinet A. Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth. Mol Cell Biol. 2007;27:7113-24 pubmed
  • 免疫印迹; 大鼠; 1:1000; 图 3
Park S, Tournell C, Sinjoanu R, Ferreira A. Caspase-3- and calpain-mediated tau cleavage are differentially prevented by estrogen and testosterone in beta-amyloid-treated hippocampal neurons. Neuroscience. 2007;144:119-27 pubmed
  • 免疫组化-石蜡切片; 人类; 1:10,000; 表 1
  • 免疫印迹; 人类; 1:10,000; 表 1
Schindowski K, Bretteville A, Leroy K, Bégard S, Brion J, Hamdane M, et al. Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. Am J Pathol. 2006;169:599-616 pubmed
  • 免疫印迹; 小鼠
Yoshida S, Maeda M, Kaku S, Ikeya H, Yamada K, Nakaike S. Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus. J Neural Transm (Vienna). 2006;113:1803-14 pubmed
  • 免疫印迹; 小鼠; 1:1000
Lobsiger C, Garcia M, Ward C, Cleveland D. Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS. Proc Natl Acad Sci U S A. 2005;102:10351-6 pubmed
  • 免疫印迹; 大鼠
Kerokoski P, Suuronen T, Salminen A, Soininen H, Pirttila T. Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation. Biochem Biophys Res Commun. 2002;298:693-8 pubmed
Zheng Y, Liu A, Wang Z, Cao Q, Wang W, Lin L, et al. Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's disease. Brain. 2019;142:787-807 pubmed 出版商
Borin M, Saraceno C, Catania M, Lorenzetto E, Pontelli V, Paterlini A, et al. Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer's disease. Acta Neuropathol Commun. 2018;6:61 pubmed 出版商
Herrera J, Ordóñez Gutiérrez L, Fabrias G, Casas J, Morales A, Hernández G, et al. Ovarian Function Modulates the Effects of Long-Chain Polyunsaturated Fatty Acids on the Mouse Cerebral Cortex. Front Cell Neurosci. 2018;12:103 pubmed 出版商
Foidl B, Humpel C. Differential Hyperphosphorylation of Tau-S199, -T231 and -S396 in Organotypic Brain Slices of Alzheimer Mice. A Model to Study Early Tau Hyperphosphorylation Using Okadaic Acid. Front Aging Neurosci. 2018;10:113 pubmed 出版商
Wang Y, Hall R, Lee M, Kamgar Parsi A, Bi X, Baudry M. The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation. Sci Rep. 2017;7:11771 pubmed 出版商
Mohamed N, Desjardins A, Leclerc N. Tau secretion is correlated to an increase of Golgi dynamics. PLoS ONE. 2017;12:e0178288 pubmed 出版商
Bodea L, Evans H, Van der Jeugd A, Ittner L, Delerue F, Kril J, et al. Accelerated aging exacerbates a pre-existing pathology in a tau transgenic mouse model. Aging Cell. 2017;16:377-386 pubmed 出版商
Park T, Ryu Y, Park H, Kim J, Go J, Noh J, et al. Humulus japonicus inhibits the progression of Alzheimer's disease in a APP/PS1 transgenic mouse model. Int J Mol Med. 2017;39:21-30 pubmed 出版商
Guo J, Narasimhan S, Changolkar L, He Z, Stieber A, Zhang B, et al. Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice. J Exp Med. 2016;213:2635-2654 pubmed
Jiang Y, Lee J, Lee J, Lee J, Kim J, Choi W, et al. The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic proteins. Autophagy. 2016;12:2197-2212 pubmed
Chen X, Wagener J, Ghribi O, Geiger J. Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease. Front Aging Neurosci. 2016;8:129 pubmed 出版商
Tiernan C, Combs B, Cox K, Morfini G, Brady S, Counts S, et al. Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. Exp Neurol. 2016;283:318-29 pubmed 出版商
Wang Y, Ren Q, Gong W, Wu D, Tang X, Li X, et al. Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT1A receptor mediated Akt/GSK-3β pathway. Oncotarget. 2016;7:13328-39 pubmed 出版商
Maeda S, Djukic B, Taneja P, Yu G, Lo I, Davis A, et al. Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. EMBO Rep. 2016;17:530-51 pubmed 出版商
Sottejeau Y, Bretteville A, Cantrelle F, Malmanche N, Demiaute F, Mendes T, et al. Tau phosphorylation regulates the interaction between BIN1's SH3 domain and Tau's proline-rich domain. Acta Neuropathol Commun. 2015;3:58 pubmed 出版商
Lane Donovan C, Philips G, Wasser C, Durakoglugil M, Masiulis I, Upadhaya A, et al. Reelin protects against amyloid β toxicity in vivo. Sci Signal. 2015;8:ra67 pubmed 出版商
Maphis N, Xu G, Kokiko Cochran O, Jiang S, Cardona A, Ransohoff R, et al. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. Brain. 2015;138:1738-55 pubmed 出版商
Sato T, Ishikawa M, Mochizuki M, Ohta M, Ohkura M, Nakai J, et al. JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration. Cell Death Differ. 2015;22:1260-74 pubmed 出版商
Ittner A, Bertz J, Suh L, Stevens C, Götz J, Ittner L. Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice. J Neurochem. 2015;132:135-45 pubmed 出版商
Oz S, Ivashko Pachima Y, Gozes I. The ADNP derived peptide, NAP modulates the tubulin pool: implication for neurotrophic and neuroprotective activities. PLoS ONE. 2012;7:e51458 pubmed 出版商
Herzig M, Bidinosti M, Schweizer T, Hafner T, Stemmelen C, Weiss A, et al. High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain. PLoS ONE. 2012;7:e36581 pubmed 出版商
Zhang Q, Gao T, Luo Y, Chen X, Gao G, Gao X, et al. Transient focal cerebral ischemia/reperfusion induces early and chronic axonal changes in rats: its importance for the risk of Alzheimer's disease. PLoS ONE. 2012;7:e33722 pubmed 出版商
Wills J, Credle J, Oaks A, Duka V, Lee J, Jones J, et al. Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways. PLoS ONE. 2012;7:e30745 pubmed 出版商
Fujimura M, Usuki F. Differing effects of toxicants (methylmercury, inorganic mercury, lead, amyloid ?, and rotenone) on cultured rat cerebrocortical neurons: differential expression of rho proteins associated with neurotoxicity. Toxicol Sci. 2012;126:506-14 pubmed 出版商
Qiang L, Yu W, Liu M, Solowska J, Baas P. Basic fibroblast growth factor elicits formation of interstitial axonal branches via enhanced severing of microtubules. Mol Biol Cell. 2010;21:334-44 pubmed 出版商
Miao Y, Chen J, Zhang Q, Sun A. Deletion of tau attenuates heat shock-induced injury in cultured cortical neurons. J Neurosci Res. 2010;88:102-10 pubmed 出版商
Saturno G, Pesenti M, Cavazzoli C, Rossi A, Giusti A, Gierke B, et al. Expression of serine/threonine protein-kinases and related factors in normal monkey and human retinas: the mechanistic understanding of a CDK2 inhibitor induced retinal toxicity. Toxicol Pathol. 2007;35:972-83 pubmed
Ahn J, Radhakrishnan M, Mapelli M, Choi S, Tidor B, Cuny G, et al. Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation. Chem Biol. 2005;12:811-23 pubmed
Paganoni S, Ferreira A. Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2. J Cell Sci. 2005;118:433-46 pubmed
Zheng Y, Kesavapany S, Gravell M, Hamilton R, Schubert M, Amin N, et al. A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons. EMBO J. 2005;24:209-20 pubmed
Bunker J, Wilson L, Jordan M, Feinstein S. Modulation of microtubule dynamics by tau in living cells: implications for development and neurodegeneration. Mol Biol Cell. 2004;15:2720-8 pubmed
Ahn J, Musacchio A, Mapelli M, Ni J, Scinto L, Stein R, et al. Development of an assay to screen for inhibitors of tau phosphorylation by cdk5. J Biomol Screen. 2004;9:122-31 pubmed
Takahashi S, Saito T, Hisanaga S, Pant H, Kulkarni A. Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules. J Biol Chem. 2003;278:10506-15 pubmed
Forno L, Langston J, Herrick M, Wilson J, Murayama S. Ubiquitin-positive neuronal and tau 2-positive glial inclusions in frontotemporal dementia of motor neuron type. Acta Neuropathol. 2002;103:599-606 pubmed
产品信息
产品类型 :
抗体
产品名称 :
Tau Monoclonal Antibody (TAU-5)
目录# :
AHB0042
规格 :
100µg
价格 :
美国331
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
Bovine, Human, Mouse, Ovine, Rat
应用 :
Immunohistochemistry (Paraffin): 1:20-1:200, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent
物种 :
Bovine, Human, Mouse, Ovine, Rat
克隆 :
TAU-5
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclindependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
免疫原 :
纯化牛微管相关蛋白
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:20-1:200, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent
别名 :
MAPT, Microtubule-associated protein tau, MTBT1, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, Tau5
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国