产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Oligomer A11 Polyclonal Antibody
目录 :
AHB0052
规格 :
50微克
价格 :
美国446
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, 斑马鱼
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 中和反应, dot blot, 其他
更多信息或购买 :
文章摘录数: 62
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 1f
Han X, Wang C, Song L, Wang X, Tang S, Hou T, et al. KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion. EBioMedicine. 2022;78:103980 pubmed 出版商
  • 其他; 斑马鱼
Pakdaman Y, Denker E, Austad E, Norton W, Rolfsnes H, Bindoff L, et al. Chip Protein U-Box Domain Truncation Affects Purkinje Neuron Morphology and Leads to Behavioral Changes in Zebrafish. Front Mol Neurosci. 2021;14:723912 pubmed 出版商
  • 免疫组化; 小鼠; 1:500; 图 1q
Vandenabeele M, Veys L, Lemmens S, Hadoux X, Gelders G, Masin L, et al. The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research. Acta Neuropathol Commun. 2021;9:6 pubmed 出版商
  • 免疫组化; 小鼠; 图 3d
Son G, Yoo S, Kang S, Rasheed A, Jung D, Park H, et al. Region-specific amyloid-β accumulation in the olfactory system influences olfactory sensory neuronal dysfunction in 5xFAD mice. Alzheimers Res Ther. 2021;13:4 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 s5g
Gasset Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, et al. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. 2019;102:339-357.e7 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s1b
Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5b
Yang S, Lee D, Shin J, Lee S, Baek S, Kim J, et al. Nec-1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice. EMBO Mol Med. 2017;9:61-77 pubmed 出版商
  • dot blot; 小鼠; 1:1000; 图 3b
Zha J, Liu X, Zhu J, Liu S, Lu S, Xu P, et al. A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses. Sci Rep. 2016;6:36631 pubmed 出版商
  • dot blot; 小鼠; 图 5c
Laclair K, Donde A, Ling J, Jeong Y, Chhabra R, Martin L, et al. Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model. Acta Neuropathol. 2016;132:859-873 pubmed
  • 免疫印迹; 人类; 图 s2
Gu M, Viles J. Methionine oxidation reduces lag-times for amyloid-?(1-40) fiber formation but generates highly fragmented fibers. Biochim Biophys Acta. 2016;1864:1260-1269 pubmed 出版商
  • 其他; 人类; 图 6
Domínguez M, de Oliveira E, Odena M, Portero M, Pamplona R, Ferrer I. Redox proteomic profiling of neuroketal-adducted proteins in human brain: Regional vulnerability at middle age increases in the elderly. Free Radic Biol Med. 2016;95:1-15 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 2
Kaufmann T, Harrison P, Richardson M, Pinheiro T, Wall M. Intracellular soluble α-synuclein oligomers reduce pyramidal cell excitability. J Physiol. 2016;594:2751-72 pubmed 出版商
Rofo F, Metzendorf N, Saubi C, Suominen L, Godec A, Sehlin D, et al. Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer's disease. Alzheimers Res Ther. 2022;14:180 pubmed 出版商
Lee H, Yoon S, Lee J, Park K, Jung Y, Cho I, et al. Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models. Alzheimers Res Ther. 2022;14:177 pubmed 出版商
Jo K, Lee D, Cha D, Oh E, Choi Y, Kim S, et al. Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ. Alzheimers Res Ther. 2022;14:158 pubmed 出版商
Xu B, He Y, Liu L, Ye G, Chen L, Wang Q, et al. The Effects of Physical Running on Dendritic Spines and Amyloid-beta Pathology in 3xTg-AD Male Mice. Aging Dis. 2022;13:1293-1310 pubmed 出版商
Alpaugh M, Masnata M, de Rus Jacquet A, Lepinay E, Denis H, Saint Pierre M, et al. Passive immunization against phosphorylated tau improves features of Huntington's disease pathology. Mol Ther. 2022;30:1500-1522 pubmed 出版商
An S, Shim K, Kang S, Kim Y, Subedi L, Cho H, et al. The potential anti-amyloidogenic candidate, SPA1413, for Alzheimer's disease. Br J Pharmacol. 2022;179:1033-1048 pubmed 出版商
Balczon R, Lin M, Lee J, Abbasi A, Renema P, Voth S, et al. Pneumonia initiates a tauopathy. FASEB J. 2021;35:e21807 pubmed 出版商
Perez Garcia G, De Gasperi R, Tschiffely A, Gama Sosa M, Abutarboush R, Kawoos U, et al. Repetitive Low-Level Blast Exposure Improves Behavioral Deficits and Chronically Lowers Aβ42 in an Alzheimer Disease Transgenic Mouse Model. J Neurotrauma. 2021;38:3146-3173 pubmed 出版商
Palanikumar L, Karpauskaite L, Al Sayegh M, Chehade I, Alam M, Hassan S, et al. Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. Nat Commun. 2021;12:3962 pubmed 出版商
Martin T, Myers V, Dubey P, Dubey S, Perez E, Moravec C, et al. Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover. Nat Commun. 2021;12:2942 pubmed 出版商
Johari M, Sarparanta J, Vihola A, Jonson P, Savarese M, Jokela M, et al. Missense mutations in small muscle protein X-linked (SMPX) cause distal myopathy with protein inclusions. Acta Neuropathol. 2021;142:375-393 pubmed 出版商
Martinez Valbuena I, Valenti Azcarate R, Amat Villegas I, Marcilla I, Martí Andrés G, Caballero M, et al. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta Neuropathol Commun. 2021;9:64 pubmed 出版商
Cascella R, Chen S, Bigi A, Camino J, Xu C, Dobson C, et al. The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells. Nat Commun. 2021;12:1814 pubmed 出版商
Hervás R, Del Carmen Fernández Ramírez M, Galera Prat A, Suzuki M, Nagai Y, Bruix M, et al. Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold. BMC Biol. 2021;19:43 pubmed 出版商
Varinthra P, Ganesan K, Huang S, Chompoopong S, Eurtivong C, Suresh P, et al. The 4-(Phenylsulfanyl) butan-2-one Improves Impaired Fear Memory Retrieval and Reduces Excessive Inflammatory Response in Triple Transgenic Alzheimer's Disease Mice. Front Aging Neurosci. 2021;13:615079 pubmed 出版商
Lee D, Park D, Kim I, Lee S, Lee W, Hwang K, et al. Plasmonic nanoparticle amyloid corona for screening Aβ oligomeric aggregate-degrading drugs. Nat Commun. 2021;12:639 pubmed 出版商
Romani M, Sorrentino V, Oh C, Li H, de Lima T, Zhang H, et al. NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle. Cell Rep. 2021;34:108660 pubmed 出版商
Santamaria G, Brandi E, Vitola P, Grandi F, Ferrara G, Pischiutta F, et al. Intranasal delivery of mesenchymal stem cell secretome repairs the brain of Alzheimer's mice. Cell Death Differ. 2021;28:203-218 pubmed 出版商
Snow W, Cadonic C, Cortes Perez C, Adlimoghaddam A, Roy Chowdhury S, Thomson E, et al. Sex-Specific Effects of Chronic Creatine Supplementation on Hippocampal-Mediated Spatial Cognition in the 3xTg Mouse Model of Alzheimer's Disease. Nutrients. 2020;12: pubmed 出版商
Tsai Y, Luo J, Liu T, Lu I, Shen M, Chuang C, et al. Capturing Amyloid-β Oligomers by Stirring with Microscaled Iron Oxide Stir Bars into Magnetic Plaques to Reduce Cytotoxicity toward Neuronal Cells. Nanomaterials (Basel). 2020;10: pubmed 出版商
Riad A, Lengyel Zhand Z, Zeng C, Weng C, Lee V, Trojanowski J, et al. The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates. Mol Neurobiol. 2020;57:3803-3813 pubmed 出版商
Abskharon R, Seidler P, Sawaya M, Cascio D, Yang T, Philipp S, et al. Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J Biol Chem. 2020;295:10662-10676 pubmed 出版商
Price D, Dorandish S, Williams A, Iwaniec B, Stephens A, Marshall K, et al. Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3. Biochemistry. 2020;59:1981-2002 pubmed 出版商
Dou J, Su P, Xu C, Wen Z, Mao Z, Li W. Targeting Hsc70-based autophagy to eliminate amyloid β oligomers. Biochem Biophys Res Commun. 2020;524:923-928 pubmed 出版商
Jin X, Wang M, Shentu J, Huang C, Bai Y, Pan H, et al. Inhibition of acetylcholinesterase activity and β-amyloid oligomer formation by 6-bromotryptamine A, a multi-target anti-Alzheimer's molecule. Oncol Lett. 2020;19:1593-1601 pubmed 出版商
Beckman D, Ott S, Donis Cox K, Janssen W, Bliss Moreau E, Rudebeck P, et al. Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging. Proc Natl Acad Sci U S A. 2019;: pubmed 出版商
Nil Z, Herv s R, Gerbich T, Leal P, Yu Z, Saraf A, et al. Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo. Cell. 2019;178:1403-1420.e21 pubmed 出版商
Zhang J, Chen B, Lu J, Wu Y, Wang S, Yao Z, et al. Brains of rhesus monkeys display Aβ deposits and glial pathology while lacking Aβ dimers and other Alzheimer's pathologies. Aging Cell. 2019;18:e12978 pubmed 出版商
Ho P, Leung C, Liu H, Pang S, Lam C, Xian J, et al. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). Autophagy. 2019;:1-24 pubmed 出版商
Wang W, Hou T, Jia L, Wu Q, Quan M, Jia J. Toxic amyloid-β oligomers induced self-replication in astrocytes triggering neuronal injury. EBioMedicine. 2019;42:174-187 pubmed 出版商
van Diggelen F, Hrle D, Apetri M, Christiansen G, Rammes G, Tepper A, et al. Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation. PLoS ONE. 2019;14:e0213663 pubmed 出版商
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产品信息
产品类型 :
抗体
产品名称 :
Oligomer A11 Polyclonal Antibody
目录# :
AHB0052
规格 :
50微克
价格 :
美国446
克隆性 :
多克隆
纯度 :
纯化
宿主 :
反应物种 :
人类, 小鼠, 大鼠
应用 :
Dot blot: 0.1-1 µg/mL, ELISA: 0.1-1 µg/mL, Immunohistochemistry: 1-5 µg/mL, Neutralization: Assay Dependent, Western Blot: Assay Dependent
物种 :
人类, 小鼠, 大鼠
抗体亚型 :
IgG
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
Many degenerative diseases are known to be related to the accumulation of misfolded proteins called, amyloid fibrils. Soluble amyloid oligomers are considered as the principal pathogenic species which play an important role in the formation of amyloid fibrils; therefore, oligomers are involved in the pathogenesis of the many neurodegenerative diseases. This anti-oligomer antibody provides a facile means of assessing the significance of oligomers in disease pathogenesis.
免疫原 :
Synthetic molecular mimic of soluble oligomers.
格式 :
液体
应用w/稀释 :
Dot blot: 0.1-1 µg/mL, ELISA: 0.1-1 µg/mL, Immunohistochemistry: 1-5 µg/mL, Neutralization: Assay Dependent, Western Blot: Assay Dependent
别名 :
IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2-rs1; Insulin; insulin 1; Insulin A chain; Insulin B chain; insulin I; insulin-1; Insulin-1 A chain; Insulin-1 B chain; IRDN; MODY10; preproinsulin; proinsulin
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国