产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
alpha突触核蛋白单克隆抗体(同义词211)
目录 :
AHB0261
规格 :
100微克
价格 :
美国500
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
同义词211
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-自由浮动切片, 其他, 免疫印迹基因敲除验证
更多信息或购买 :
文章摘录数: 36
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 5c
Cai M, Chai S, Xiong T, Wei J, Mao W, Zhu Y, et al. Aberrant Expression of Circulating MicroRNA Leads to the Dysregulation of Alpha-Synuclein and Other Pathogenic Genes in Parkinson's Disease. Front Cell Dev Biol. 2021;9:695007 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 5a, 5b, 5c, 5d
Anandhan A, Nguyen N, Syal A, Dreher L, Dodson M, Zhang D, et al. NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human α-Synuclein Overexpressing Mice. Aging Dis. 2021;12:964-982 pubmed 出版商
  • 免疫组化; 人类; 1:1000; 图 s2a
Bengoa Vergniory N, Faggiani E, Ramos Gonzalez P, Kirkiz E, Connor Robson N, Brown L, et al. CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease. Nat Commun. 2020;11:4885 pubmed 出版商
  • 其他; 小鼠; 1:500; 图 4
Cupo R, Shorter J. Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations. elife. 2020;9: pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 1:1000; 图 6a
  • 免疫细胞化学; 人类; 1:400; 图 5b, 8
Zhang S, Eitan E, Wu T, Mattson M. Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal. Neurobiol Aging. 2018;61:52-65 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1b
de Oliveira G, Marques M, Cruzeiro Silva C, Cordeiro Y, Schuabb C, Moraes A, et al. Structural basis for the dissociation of ?-synuclein fibrils triggered by pressure perturbation of the hydrophobic core. Sci Rep. 2016;6:37990 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Kang W, Chen W, Yang Q, Zhang L, Zhang L, Wang X, et al. Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson's disease patients. Sci Rep. 2016;6:28143 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Caviness J, Lue L, Hentz J, Schmitz C, Adler C, Shill H, et al. Cortical phosphorylated α-Synuclein levels correlate with brain wave spectra in Parkinson's disease. Mov Disord. 2016;31:1012-9 pubmed 出版商
  • 免疫组化; 小鼠; 图 1
Kim C, Ojo Amaize E, Spencer B, Rockenstein E, Mante M, Desplats P, et al. Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease. J Neuroinflammation. 2015;12:236 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Spencer B, Valera E, Rockenstein E, Trejo Morales M, Adame A, Masliah E. A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy. Mol Neurodegener. 2015;10:48 pubmed 出版商
  • 免疫组化; 人类; 1:1000; 图 1
Bourdenx M, Dovero S, Engeln M, Bido S, Bastide M, Dutheil N, et al. Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression. Acta Neuropathol Commun. 2015;3:46 pubmed 出版商
  • 酶联免疫吸附测定; 人类
Wang X, Kang W, Yang Q, Zhang L, Chen S, Liu J. Using gastrocnemius sEMG and plasma ?-synuclein for the prediction of freezing of gait in Parkinson's disease patients. PLoS ONE. 2014;9:e89353 pubmed 出版商
  • 免疫组化-自由浮动切片; 大鼠; 1:1000
Reyes J, Rey N, Bousset L, Melki R, Brundin P, Angot E. Alpha-synuclein transfers from neurons to oligodendrocytes. Glia. 2014;62:387-98 pubmed 出版商
  • 免疫组化-自由浮动切片; 人类; 1:2000; 图 2
Gombash S, Manfredsson F, Kemp C, Kuhn N, Fleming S, Egan A, et al. Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system. PLoS ONE. 2013;8:e81426 pubmed 出版商
  • 免疫印迹; 人类
Rieker C, Dev K, Lehnhoff K, Barbieri S, Ksiazek I, Kauffmann S, et al. Neuropathology in mice expressing mouse alpha-synuclein. PLoS ONE. 2011;6:e24834 pubmed 出版商
Liu X, Balaraman K, Lynch C, Hebron M, Shah P, Hu S, et al. Inhibition of Ubiquitin-Specific Protease-13 Improves Behavioral Performance in Alpha-Synuclein Expressing Mice. Int J Mol Sci. 2022;23: pubmed 出版商
Medina C, Vargas E, Munger S, Miller J. Vocal changes in a zebra finch model of Parkinson's disease characterized by alpha-synuclein overexpression in the song-dedicated anterior forebrain pathway. PLoS ONE. 2022;17:e0265604 pubmed 出版商
Zhu Y, Bian J, Lu D, To C, Lam C, Li K, et al. Alteration of EIF2 Signaling, Glycolysis, and Dopamine Secretion in Form-Deprived Myopia in Response to 1% Atropine Treatment: Evidence From Interactive iTRAQ-MS and SWATH-MS Proteomics Using a Guinea Pig Model. Front Pharmacol. 2022;13:814814 pubmed 出版商
Liu X, Balaraman K, Lynch C, Hebron M, Wolf C, Moussa C. Novel Ubiquitin Specific Protease-13 Inhibitors Alleviate Neurodegenerative Pathology. Metabolites. 2021;11: pubmed 出版商
Wang H, Qi W, Zou C, Xie Z, Zhang M, Naito M, et al. NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation. Nat Commun. 2021;12:4826 pubmed 出版商
Fernandez Espejo E, Rodriguez de Fonseca F, Suarez J, Tolosa E, Vilas D, Aldecoa I, et al. Native α-Synuclein, 3-Nitrotyrosine Proteins, and Patterns of Nitro-α-Synuclein-Immunoreactive Inclusions in Saliva and Submandibulary Gland in Parkinson's Disease. Antioxidants (Basel). 2021;10: pubmed 出版商
Brekk O, Honey J, Lee S, Hallett P, Isacson O. Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance. Proc Natl Acad Sci U S A. 2020;117:27646-27654 pubmed 出版商
Murakami H, Tokuda T, El Agnaf O, Ohmichi T, Miki A, Ohashi H, et al. Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson's disease. BMC Neurol. 2019;19:113 pubmed 出版商
Uehara T, Choong C, Nakamori M, Hayakawa H, Nishiyama K, Kasahara Y, et al. Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease. Sci Rep. 2019;9:7567 pubmed 出版商
Krejciova Z, Carlson G, Giles K, Prusiner S. Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein. Acta Neuropathol Commun. 2019;7:81 pubmed 出版商
Harischandra D, Rokad D, Neal M, Ghaisas S, Manne S, Sarkar S, et al. Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein. Sci Signal. 2019;12: pubmed 出版商
Li X, Koudstaal W, Fletcher L, Costa M, Van Winsen M, Siregar B, et al. Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology. Acta Neuropathol. 2019;137:825-836 pubmed 出版商
Humphreys C, Jansen M, Muñoz Maniega S, González Castro V, Pernet C, Deary I, et al. A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology. Int J Stroke. 2019;14:310-320 pubmed 出版商
Henrich M, Geibl F, Lee B, Chiu W, Koprich J, Brotchie J, et al. A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia. Acta Neuropathol Commun. 2018;6:39 pubmed 出版商
Cai W, Feng D, Schwarzschild M, McLean P, Chen X. Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice. EBioMedicine. 2018;29:13-22 pubmed 出版商
Recasens A, Carballo Carbajal I, Parent A, Bove J, Gelpi E, Tolosa E, et al. Lack of pathogenic potential of peripheral ?-synuclein aggregates from Parkinson's disease patients. Acta Neuropathol Commun. 2018;6:8 pubmed 出版商
Zunke F, Moise A, Belur N, Gelyana E, Stojkovska I, Dzaferbegovic H, et al. Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide. Neuron. 2018;97:92-107.e10 pubmed 出版商
Rockenstein E, Ostroff G, Dikengil F, Rus F, Mante M, Florio J, et al. Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies. J Neurosci. 2018;38:1000-1014 pubmed 出版商
Fischer D, Manfredsson F, Kemp C, Cole Strauss A, Lipton J, Duffy M, et al. Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression. Sci Rep. 2017;7:16356 pubmed 出版商
Xu C, Kang W, Chen Y, Jiang T, Zhang J, Zhang L, et al. DJ-1 Inhibits ?-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy. Front Aging Neurosci. 2017;9:308 pubmed 出版商
Spencer B, Valera E, Rockenstein E, OVERK C, Mante M, Adame A, et al. Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy. Acta Neuropathol Commun. 2017;5:7 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
alpha突触核蛋白单克隆抗体(同义词211)
目录# :
AHB0261
规格 :
100微克
价格 :
美国500
克隆性 :
单克隆
纯度 :
蛋白质A/G
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: Assay Dependent, Immunocytochemistry: 1 µg/mL, Immunofluorescence: 1 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 1 µg/mL
物种 :
人类
克隆 :
同义词211
抗体亚型 :
IgG1
储存 :
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
描述 :
Alpha-Synuclein belongs to the Synuclein family, which includes beta and gamma Synuclein, and is predominantly expressed in neurons, and concentrated at synaptic terminals. Synucleins may be involved in the regulation of dopamine release and transport and the modulation of synaptic vesicle function. Alpha-Synuclein is a small, presynaptic protein that is the major nonamyloid component of the pathological inclusions characteristic of a wide range of neurodegenerative disorders, collectively known as synucleinopathies. Alpha-Synuclein is involved in the formation of SNARE complexes, and most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders. Mutation of the alpha-synuclein gene is associated with familial forms of PD. Alpha-Synuclein is known to reduce the fibrillization of the microtubule-associated protein, tau, to bind various targets such as 14-3-3, protein kinase C, synphilin-1, Elk and Tat-binding protein 1. The alpha and beta synucleins are found primarily in brain tissue where they are seen mainly in neuronal cytosol and presynaptic terminals. The antibody specific for alpha-synuclein does not cross react with beta-synuclein and will be useful for the confirmation of Parkinson's disease and Lewy body dementia and other studies for the localization and detection of alpha-synuclein. Four alternatively spliced transcripts that encode two different isoforms of the alpha-synuclein protein have been identified.
免疫原 :
重组人类alpha突触核蛋白
格式 :
液体
应用w/稀释 :
ELISA: Assay Dependent, Immunocytochemistry: 1 µg/mL, Immunofluorescence: 1 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:50, Western Blot: 1 µg/mL
别名 :
Alpha synuclein; alphaSYN; Alpha-synuclein; MGC110988; MGC110988 antibody; NACP; NACP antibody; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; OTTHUMP00000218549; OTTHUMP00000218551; OTTHUMP00000218552; OTTHUMP00000218553; OTTHUMP00000218554; PARK 1; PARK 1 antibody; PARK 4; PARK 4 antibody; PARK1; PARK1 antibody; PARK4; PARK4 antibody; PD 1 antibody; PD1; PD1 antibody; Snca; SNCA antibody; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor); SYUA
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国