产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-1 beta Antibody Cocktail
目录 :
AHC0612
规格 :
500微克
价格 :
美国456
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
508A4A2和508A7G8
反应物种 :
人类
应用 :
酶联免疫吸附测定
更多信息或购买 :
文章摘录数: 3
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| Olson N, Graves J, Shu G, Ryan E, Clark E. Caspase activity is required for stimulated B lymphocytes to enter the cell cycle. J Immunol. 2003;170:6065-72 pubmed
|
| Kooijman R, Coppens A, Hooghe Peters E. Igf-I inhibits spontaneous apoptosis in human granulocytes. Endocrinology. 2002;143:1206-12 pubmed
|
Kesavalu L, Falk C, Davis K, Steffen M, Xu X, Holt S, et al. Biological characterization of lipopolysaccharide from Treponema pectinovorum. Infect Immun. 2002;70:211-7 pubmed
|
产品信息
产品类型 :
抗体
产品名称 :
IL-1 beta Antibody Cocktail
目录# :
AHC0612
规格 :
500微克
价格 :
美国456
克隆性 :
Cocktail
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA:依实验方法而定
物种 :
人类
克隆 :
508A4A2和508A7G8
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
免疫原 :
重组人类IL-1b
格式 :
液体
应用w/稀释 :
ELISA:依实验方法而定
别名 :
catabolin; cytokine; il 1b; IL 1ß; IL-1; IL1 B; IL-1 beta; IL-1 precursor; IL1B; Il-1b; IL1B1; IL1beta; IL-1beta; IL1-BETA; IL1F2; IL1ß; ILN; Interleukin; interleukin 1 beta; interleukin 1, beta; interleukin 1, beta 1; interleukin 1-beta; Interleukin1 beta; interleukin-1 beta; interleukin-1 beta precursor; interleukin-1 beta precursor (AA -113 to 153); interleukin-1 beta proprotein; interleukin-1 beta-like; Interleukin-1b; interleukin-beta; LOC100052414; lymphocyte proliferation-potentiating factor; preinterleukin 1 beta; prointerleukin-1 beta; pro-interleukin-1-beta
更多信息或购买 :
公司信息
赛默飞世尔