产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
肿瘤坏死因子甲单克隆抗体(68B 3C5), 生物素
目录 :
AHC3419
规格 :
100微克
价格 :
美国446
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
生物素
克隆名称 :
68B 3C5
反应物种 :
人类
应用 :
酶联免疫吸附测定
更多信息或购买 :
文章摘录数: 12
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| |
| Gorden K, Qiu X, Battiste J, Wightman P, Vasilakos J, Alkan S. Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines. J Immunol. 2006;177:8164-70 pubmed
|
| Inglefield J, Larson C, Gibson S, Lebrec H, Miller R. Apoptotic responses in squamous carcinoma and epithelial cells to small-molecule toll-like receptor agonists evaluated with automated cytometry. J Biomol Screen. 2006;11:575-85 pubmed
|
| Vinogradov E, Paul C, Li J, Zhou Y, Lyle E, Tapping R, et al. The structure and biological characteristics of the Spirochaeta aurantia outer membrane glycolipid LGLB. Eur J Biochem. 2004;271:4685-95 pubmed
|
| Gee K, Kozlowski M, Kumar A. Tumor necrosis factor-alpha induces functionally active hyaluronan-adhesive CD44 by activating sialidase through p38 mitogen-activated protein kinase in lipopolysaccharide-stimulated human monocytic cells. J Biol Chem. 2003;278:37275-87 pubmed
|
| Gee K, Lim W, Ma W, Nandan D, Diaz Mitoma F, Kozlowski M, et al. Differential regulation of CD44 expression by lipopolysaccharide (LPS) and TNF-alpha in human monocytic cells: distinct involvement of c-Jun N-terminal kinase in LPS-induced CD44 expression. J Immunol. 2002;169:5660-72 pubmed
|
| Braun M, Wang J, Lahey E, Rabin R, Kelsall B. Activation of the formyl peptide receptor by the HIV-derived peptide T-20 suppresses interleukin-12 p70 production by human monocytes. Blood. 2001;97:3531-6 pubmed
|
| Bullens D, Rafiq K, Charitidou L, Peng X, Kasran A, Warmerdam P, et al. Effects of co-stimulation by CD58 on human T cell cytokine production: a selective cytokine pattern with induction of high IL-10 production. Int Immunol. 2001;13:181-91 pubmed
|
| Braun M, Lahey E, Kelsall B. Selective suppression of IL-12 production by chemoattractants. J Immunol. 2000;164:3009-17 pubmed
|
| Braun M, He J, Wu C, Kelsall B. Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression. J Exp Med. 1999;189:541-52 pubmed
|
Baggio V, Ott F, Fischer R, Gram H, Peele J, Spreng D, et al. Production of antibodies to canine IL-1beta and canine TNF to assess the role of proinflammatory cytokines. Vet Immunol Immunopathol. 2005;107:27-39 pubmed
| |
Gorden K, Gorski K, Gibson S, Kedl R, Kieper W, Qiu X, et al. Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J Immunol. 2005;174:1259-68 pubmed
|
产品信息
产品类型 :
抗体
产品名称 :
肿瘤坏死因子甲单克隆抗体(68B 3C5), 生物素
目录# :
AHC3419
规格 :
100微克
价格 :
美国446
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA:依实验方法而定
物种 :
人类
克隆 :
68B 3C5
抗体亚型 :
IgG1
储存 :
4° C
描述 :
TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
免疫原 :
纯化重组人类肿瘤坏死因子甲
格式 :
液体
应用w/稀释 :
ELISA:依实验方法而定
别名 :
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; Tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
更多信息或购买 :
公司信息
赛默飞世尔