产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-10单克隆抗体(945A5A10), 生物素
目录 :
AHC7109
规格 :
100微克
价格 :
美国446
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
生物素
克隆名称 :
945A5A10
反应物种 :
South American squirrel monkey, African green monkey, baboon
应用 :
酶联免疫吸附测定
更多信息或购买 :
文章摘录数: 8
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| |
| |
| Thom F, Stockhausen H, Germann T, Frosch S, Wade E. Biological inactivation and impaired detection of IL-10 by suramin. J Immunol Methods. 2005;299:91-8 pubmed
|
| Farah I, Mola P, Kariuki T, Nyindo M, Blanton R, King C. Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4. J Immunol. 2000;164:5337-43 pubmed
|
| Braun M, Lahey E, Kelsall B. Selective suppression of IL-12 production by chemoattractants. J Immunol. 2000;164:3009-17 pubmed
|
| Mola P, Farah I, Kariuki T, Nyindo M, Blanton R, King C. Cytokine control of the granulomatous response in Schistosoma mansoni-infected baboons: role of exposure and treatment. Infect Immun. 1999;67:6565-71 pubmed
|
| Kenney R, Sacks D, Sypek J, Vilela L, Gam A, Evans Davis K. Protective immunity using recombinant human IL-12 and alum as adjuvants in a primate model of cutaneous leishmaniasis. J Immunol. 1999;163:4481-8 pubmed
|
| Braun M, He J, Wu C, Kelsall B. Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression. J Exp Med. 1999;189:541-52 pubmed
|
产品信息
产品类型 :
抗体
产品名称 :
IL-10单克隆抗体(945A5A10), 生物素
目录# :
AHC7109
规格 :
100微克
价格 :
美国446
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA:依实验方法而定
物种 :
人类
克隆 :
945A5A10
抗体亚型 :
IgG1, kappa
储存 :
4° C
描述 :
Interleukin 10 (IL-10, CSIF) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 is an 18.6 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr Virus protein (BCRFI). The reported biological activities of IL-10, which maybe interrelated, include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed-type hyper-sensitivity response, and stimulation of the Th2 cell response which results in elevated antibody production. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells, enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells. Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). IL-10 inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Knockout studies in mice suggest the function of this cytokine as an essential immunoregulator in the intestinal tract.
免疫原 :
重组人类IL-10
格式 :
液体
应用w/稀释 :
ELISA:依实验方法而定
别名 :
CSIF; cytokine; cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; Interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
更多信息或购买 :
公司信息
赛默飞世尔