产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
SRC(活性的)单克隆抗体(28)
目录 :
AHO0051
规格 :
50微克
价格 :
美国450
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
28
反应物种 :
人类, 小鼠, 大鼠, 斑马鱼
应用 :
免疫印迹, 免疫组化, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 15
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 1:400; 图 f1a
  • 免疫印迹; 人类; 1:1000; 图 f2
Mello A, Leal M, Rey J, Pinto G, Lamarão L, Montenegro R, et al. Deregulated Expression of SRC, LYN and CKB Kinases by DNA Methylation and Its Potential Role in Gastric Cancer Invasiveness and Metastasis. PLoS ONE. 2015;10:e0140492 pubmed 出版商
  • 免疫印迹; 小鼠
McGinnis L, Pelech S, Kinsey W. Post-ovulatory aging of oocytes disrupts kinase signaling pathways and lysosome biogenesis. Mol Reprod Dev. 2014;81:928-45 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Lee Y, Chung S, Baek I, Lee T, Paik S, Lee J. UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis. Cell Cycle. 2013;12:1303-15 pubmed 出版商
  • 免疫印迹; 小鼠; 1:50,000; 图 3
Tremper Wells B, Resnick R, Zheng X, Holsinger L, Shalloway D. Extracellular domain dependence of PTPalpha transforming activity. Genes Cells. 2010;15:711-724 pubmed 出版商
  • 免疫印迹; 人类
Hu X, Dang Y, Tenney K, Crews P, Tsai C, Sixt K, et al. Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem Biol. 2007;14:764-74 pubmed
  • 免疫组化-冰冻切片; 斑马鱼; 2.5 ug/ml
Sharma D, Kinsey W. Fertilization triggers localized activation of Src-family protein kinases in the zebrafish egg. Dev Biol. 2006;295:604-14 pubmed
Shabangu C, Siphepho P, Li C, Cheng W, Lu M, Huang C, et al. The Persistence of Hepatitis C Virus Infection in Hepatocytes Promotes Hepatocellular Carcinoma Progression by Pro-Inflammatory Interluekin-8 Expression. Biomedicines. 2021;9: pubmed 出版商
Mir C, Garcia Mayea Y, Garcia L, Herrero P, Canela N, Tabernero R, et al. SDCBP Modulates Stemness and Chemoresistance in Head and Neck Squamous Cell Carcinoma through Src Activation. Cancers (Basel). 2021;13: pubmed 出版商
Garcia Mayea Y, Mir C, Carballo L, Castellvi J, Temprana Salvador J, Lorente J, et al. TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance. Cancers (Basel). 2020;12: pubmed 出版商
Grafinger O, Gorshtein G, Stirling T, Brasher M, Coppolino M. β1 integrin-mediated signaling regulates MT1-MMP phosphorylation to promote tumor cell invasion. J Cell Sci. 2020;133: pubmed 出版商
Li Y, Jiang G, Chen L, Jiang Y, Jiao J. Formin mDia1 contributes to migration and epithelial-mesenchymal transition of tubular epithelial cells exposed to TGF-β1. J Cell Biochem. 2020;121:3861-3870 pubmed 出版商
Hermida Prado F, Granda Díaz R, Del Río Ibisate N, Villaronga M, Allonca E, Garmendia I, et al. The Differential Impact of SRC Expression on the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2019;11: pubmed 出版商
Roycroft A, Szabo A, Bahm I, Daly L, Charras G, Parsons M, et al. Redistribution of Adhesive Forces through Src/FAK Drives Contact Inhibition of Locomotion in Neural Crest. Dev Cell. 2018;45:565-579.e3 pubmed 出版商
Bernard Trifilo J, Lim S, Hou S, Schlaepfer D, Ilic D. Analyzing FAK and Pyk2 in early integrin signaling events. Curr Protoc Cell Biol. 2006;Chapter 14:Unit 14.7 pubmed 出版商
Shimizu A, Maruyama T, Tamaki K, Uchida H, Asada H, Yoshimura Y. Impairment of decidualization in SRC-deficient mice. Biol Reprod. 2005;73:1219-27 pubmed
产品信息
产品类型 :
抗体
产品名称 :
SRC(活性的)单克隆抗体(28)
目录# :
AHO0051
规格 :
50微克
价格 :
美国450
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunohistochemistry: Assay Dependent, Western Blot: 1.0 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
28
抗体亚型 :
IgG2a, kappa
储存 :
-20°C
描述 :
SRC is a non-receptor kinase involved in the regulation of growth and differentiation of eukaryotic cells. SRC associates with the cytoplasmic region of various cell surface receptors to facilitate signal transduction, and is also involved in cytoskeletal organization, cell cycle regulation, and apoptosis. In humans, the gene encoding SRC is present on chromosome 20. Activity of SRC is regulated by two tyrosine residues (Tyr 416 and Tyr527), and phosphorylation of these two sites have opposing effects. Phosphorylation of Tyr416 in the activation loop of the kinase domain upregulates enzyme activity while the phosphorylation of Tyr527 decreases enzyme activity. Mutations in the SRC gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been found thus far.
免疫原 :
KLH conjugated peptide corresponding to amino acid residues 519-536 of human c-Src.
格式 :
液体
应用w/稀释 :
Immunohistochemistry: Assay Dependent, Western Blot: 1.0 µg/mL
别名 :
ASV; AW259666; csrc; c-Src; EC 2.7.10.2; Neuronal proto-oncogene tyrosine-protein kinase Src; non-tyrosine protein kinase; OTTHUMP00000174476; OTTHUMP00000174477; OTTHUMP00000174478; p60-Src; p60-Src-1; PP60C-SCR; pp60c-src; pp60src; pp60v-src; Proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; proto-oncogene tyrosine-protein kinase Src; Rous sarcoma oncogene; RP5-823N20.1; SDR; src; src oncogene; SRC proto-oncogene, non-receptor tyrosine kinase; SRC proto-oncogene, non-receptor tyrosine kinase L homeolog; SRC proto-oncogene, non-receptor tyrosine kinase S homeolog; src.L; src.S; SRC1; src-1; src1-A; src-a; src-b; THC6; transforming protein; tyrosine kinase pp60c-src; tyrosine protein kinase c-src; tyrosine protein kinase pp60-c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma viral oncogene; XELAEV_18046582mg; xsrc
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国