产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
EIF2S1单克隆抗体(真核起始因子2甲)
目录 :
AHO0802
规格 :
100微克
价格 :
美国450
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
真核起始因子2甲
反应物种 :
African green monkey, 人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 41
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 4g
Guo X, Aviles G, Liu Y, Tian R, Unger B, Lin Y, et al. Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Nature. 2020;579:427-432 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2000; 图 7h
Santos M, Anderson C, Neschen S, Zumbrennen Bullough K, Romney S, Kahle Stephan M, et al. Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification. Nat Commun. 2020;11:296 pubmed 出版商
  • 免疫印迹; 人类; 图 s5a
Chung H, Calis J, Wu X, Sun T, Yu Y, Sarbanes S, et al. Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown. Cell. 2018;172:811-824.e14 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1a
Silva R, Sattlegger E, Castilho B. Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response. J Cell Sci. 2016;129:4521-4533 pubmed
  • 免疫印迹; 人类; 图 5
Mohammad S, Wolfe L, Stöbe P, Biskup S, Wainwright M, Melin Aldana H, et al. Infantile Cirrhosis, Growth Impairment, and Neurodevelopmental Anomalies Associated with Deficiency of PPP1R15B. J Pediatr. 2016;179:144-149.e2 pubmed 出版商
  • 免疫印迹; 小鼠
Maas N, Singh N, Diehl J. Generation and characterization of an analog-sensitive PERK allele. Cancer Biol Ther. 2014;15:1106-11 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3
Hengstermann A, Muller T. Endoplasmic reticulum stress induced by aqueous extracts of cigarette smoke in 3T3 cells activates the unfolded-protein-response-dependent PERK pathway of cell survival. Free Radic Biol Med. 2008;44:1097-107 pubmed 出版商
  • 免疫印迹; 人类
Shah A, Parker J, Gillespie G, Lakeman F, Meleth S, Markert J, et al. Enhanced antiglioma activity of chimeric HCMV/HSV-1 oncolytic viruses. Gene Ther. 2007;14:1045-54 pubmed
  • 免疫印迹; African green monkey
Cassady K. Human cytomegalovirus TRS1 and IRS1 gene products block the double-stranded-RNA-activated host protein shutoff response induced by herpes simplex virus type 1 infection. J Virol. 2005;79:8707-15 pubmed
Chen M, Hsu L, Wang S, Pan Y, Lo J, Yeh T, et al. Salubrinal Enhances Cancer Cell Death during Glucose Deprivation through the Upregulation of xCT and Mitochondrial Oxidative Stress. Biomedicines. 2021;9: pubmed 出版商
Gabaev I, Williamson J, Crozier T, Schulz T, Lehner P. Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation. Cell Rep. 2020;33:108249 pubmed 出版商
Ortega J, Daley E, Kour S, Samani M, Tellez L, Smith H, et al. Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity. Neuron. 2020;106:90-107.e13 pubmed 出版商
Rubio R, Mohr I. Inhibition of ULK1 and Beclin1 by an α-herpesvirus Akt-like Ser/Thr kinase limits autophagy to stimulate virus replication. Proc Natl Acad Sci U S A. 2019;: pubmed 出版商
Claes Z, Jonkhout M, Crespillo Casado A, Bollen M. The antibiotic robenidine exhibits guanabenz-like cytoprotective properties by a mechanism independent of protein phosphatase PP1:PPP1R15A. J Biol Chem. 2019;294:13478-13486 pubmed 出版商
Wang Y, Chien Y, Hsiao W, Wang C, Wang S. Fission Yeast Asc1 Stabilizes the Interaction between Eukaryotic Initiation Factor 3a and Rps0A/uS2 for Protein Synthesis. Mol Cell Biol. 2019;39: pubmed 出版商
Patel V, Bidault G, Chambers J, Carobbio S, Everden A, Garcés C, et al. Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice. Sci Rep. 2019;9:2903 pubmed 出版商
Pan D, Li G, Morris Love J, Qi S, Feng L, Mertens M, et al. Herpes Simplex Virus 1 Lytic Infection Blocks MicroRNA (miRNA) Biogenesis at the Stage of Nuclear Export of Pre-miRNAs. MBio. 2019;10: pubmed 出版商
Silva R, Castilho B, Sattlegger E. A Rapid Extraction Method for mammalian cell cultures, suitable for quantitative immunoblotting analysis of proteins, including phosphorylated GCN2 and eIF2α. MethodsX. 2018;5:75-82 pubmed 出版商
Bittremieux M, La Rovere R, Schuermans M, Luyten T, Mikoshiba K, Vangheluwe P, et al. Extracellular and ER-stored Ca2+ contribute to BIRD-2-induced cell death in diffuse large B-cell lymphoma cells. Cell Death Discov. 2018;4:101 pubmed 出版商
Jeon Y, Shin J, Lee S, Lee Y, Kim J, Kwon H, et al. Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis. Biomed Res Int. 2018;2018:6716547 pubmed 出版商
Teo C, O Hare P. A bimodal switch in global protein translation coupled to eIF4H relocalisation during advancing cell-cell transmission of herpes simplex virus. PLoS Pathog. 2018;14:e1007196 pubmed 出版商
Burgess H, Pourchet A, Hajdu C, Chiriboga L, Frey A, Mohr I. Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus. Mol Ther Oncolytics. 2018;8:71-81 pubmed 出版商
Taga M, Mouton Liger F, Sadoune M, Gourmaud S, Norman J, Tible M, et al. PKR modulates abnormal brain signaling in experimental obesity. PLoS ONE. 2018;13:e0196983 pubmed 出版商
Liu X, Main D, Ma Y, He B. Herpes Simplex Virus 1 Inhibits TANK-Binding Kinase 1 through Formation of the Us11-Hsp90 Complex. J Virol. 2018;92: pubmed 出版商
Frey T, Forsyth K, Sheehan M, De Haven B, Pevarnik J, Hand E, et al. Ectromelia virus lacking the E3L ortholog is replication-defective and nonpathogenic but does induce protective immunity in a mouse strain susceptible to lethal mousepox. Virology. 2018;518:335-348 pubmed 出版商
Nakashima H, Nguyen T, Kasai K, Passaro C, Ito H, Goins W, et al. Toxicity and Efficacy of a Novel GADD34-expressing Oncolytic HSV-1 for the Treatment of Experimental Glioblastoma. Clin Cancer Res. 2018;24:2574-2584 pubmed 出版商
Hurwitz S, Cheerathodi M, Nkosi D, York S, Meckes D. Tetraspanin CD63 Bridges Autophagic and Endosomal Processes To Regulate Exosomal Secretion and Intracellular Signaling of Epstein-Barr Virus LMP1. J Virol. 2018;92: pubmed 出版商
Manivanh R, Mehrbach J, Knipe D, Leib D. Role of Herpes Simplex Virus 1 γ34.5 in the Regulation of IRF3 Signaling. J Virol. 2017;91: pubmed 出版商
Demirtas L, Guclu A, Erdur F, Akbas E, Ozçiçek A, Onk D, et al. Apoptosis, autophagy & endoplasmic reticulum stress in diabetes mellitus. Indian J Med Res. 2016;144:515-524 pubmed 出版商
To M, Peterson C, Roberts M, Counihan J, Wu T, Forster M, et al. Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation. Mol Biol Cell. 2017;28:270-284 pubmed 出版商
Hodgson L, Spiering D, Sabouri Ghomi M, Dagliyan O, DerMardirossian C, Danuser G, et al. FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions. Nat Chem Biol. 2016;12:802-809 pubmed 出版商
Nelson E, Schmidt K, Deflubé L, DoÄŸanay S, Banadyga L, Olejnik J, et al. Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral Inclusions. J Virol. 2016;90:7268-7284 pubmed 出版商
Blas Rus N, Bustos Morán E, Perez de Castro I, de Carcer G, Borroto A, Camafeita E, et al. Aurora A drives early signalling and vesicle dynamics during T-cell activation. Nat Commun. 2016;7:11389 pubmed 出版商
Wanders D, Stone K, Forney L, Cortez C, Dille K, Simon J, et al. Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction. Diabetes. 2016;65:1499-510 pubmed 出版商
Messner B, Türkcan A, Ploner C, Laufer G, Bernhard D. Cadmium overkill: autophagy, apoptosis and necrosis signalling in endothelial cells exposed to cadmium. Cell Mol Life Sci. 2016;73:1699-713 pubmed 出版商
Niehues S, Bussmann J, Steffes G, Erdmann I, Köhrer C, Sun L, et al. Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases. Nat Commun. 2015;6:7520 pubmed 出版商
Chambers J, Dalton L, Clarke H, Malzer E, Dominicus C, Patel V, et al. Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation. elife. 2015;4: pubmed 出版商
Thelen M, Damme M, Daμμe M, Schweizer M, Hagel C, Wong A, et al. Disruption of the autophagy-lysosome pathway is involved in neuropathology of the nclf mouse model of neuronal ceroid lipofuscinosis. PLoS ONE. 2012;7:e35493 pubmed 出版商
Trottier M, Palian B, Reiss C. VSV replication in neurons is inhibited by type I IFN at multiple stages of infection. Virology. 2005;333:215-25 pubmed
Ramos Castaneda J, Park Y, Liu M, Hauser K, Rudolph H, Shull G, et al. Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in endoplasmic reticulum (ER)-associated degradation and sensitivity to ER stress. J Biol Chem. 2005;280:9467-73 pubmed
Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, et al. The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol. 2002;22:3864-74 pubmed
产品信息
产品类型 :
抗体
产品名称 :
EIF2S1单克隆抗体(真核起始因子2甲)
目录# :
AHO0802
规格 :
100微克
价格 :
美国450
克隆性 :
单克隆
纯度 :
蛋白质A/G
宿主 :
小鼠
反应物种 :
Human, Mouse, Non-human primate, Rat
应用 :
Flow Cytometry: 3-5 µg/1x10^6 cells, Immunocytochemistry: 1 µg/mL, Immunofluorescence: 1 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:50, Immunoprecipitation: Assay Dependent, Western Blot: 1:500-1:1000
物种 :
Human, Mouse, Non-human primate, Rat
克隆 :
真核起始因子2甲
抗体亚型 :
IgG1
储存 :
-20°C
描述 :
EIF2a (Eukaryotic translation initiation factor 2A) is a heterotrimer composed of three subunits (alpha, beta, and gamma). This translation initiation factor drives binding of initiator methionyl-tRNA to the 40S ribosome in an AUG-dependent manner to form the 43S pre-initiation complex. The polypeptide can be phosphorylated by related protein kinases activated in response to stress. Phosphorylated EIF2A inhibits EIF2B activity and prevents guanine nucleotide exchange.
免疫原 :
重组人类eIF-2
格式 :
液体
应用w/稀释 :
Flow Cytometry: 3-5 µg/1x10^6 cells, Immunocytochemistry: 1 µg/mL, Immunofluorescence: 1 µg/mL, Immunohistochemistry (Paraffin): 1:10-1:50, Immunoprecipitation: Assay Dependent, Western Blot: 1:500-1:1000
别名 :
0910001O23Rik; 2410026C18Rik; 35kDa; EIF2; EIF-2; eIF2 alpha; EIF2A; EIF-2A; eIF2alpha; eIF-2alpha; eIF-2-alpha; EIF2S1; eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eukaryotic translation initiation factor 2, subunit 1 alpha; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; eukaryotic translation initiation factor 2A
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国