产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
SRC单克隆抗体(184Q20)
目录 :
AHO1152
规格 :
100微克
价格 :
美国500
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
184Q20
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 11
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 6b
Bergsma A, Ganguly S, Wiegand M, Dick D, Williams B, Miranti C. Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82. Bone Rep. 2019;10:100196 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:200
Kupferman J, Basu J, Russo M, Guevarra J, Cheung S, Siegelbaum S. Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment. Cell. 2014;158:1335-1347 pubmed 出版商
  • 免疫印迹; 小鼠
Spulber S, Mateos L, Oprica M, Cedazo Minguez A, Bartfai T, Winblad B, et al. Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain. J Neuroimmunol. 2009;208:46-53 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6
Waschbüsch D, Born S, Niediek V, Kirchgessner N, Tamboli I, Walter J, et al. Presenilin 1 affects focal adhesion site formation and cell force generation via c-Src transcriptional and posttranslational regulation. J Biol Chem. 2009;284:10138-49 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Yano N, Suzuki D, Endoh M, Tseng A, Stabila J, McGonnigal B, et al. Beta-adrenergic receptor mediated protection against doxorubicin-induced apoptosis in cardiomyocytes: the impact of high ambient glucose. Endocrinology. 2008;149:6449-61 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Honda K, Sakaguchi T, Sakai K, Schmedt C, Ramirez A, Jorcano J, et al. Epidermal hyperplasia and papillomatosis in mice with a keratinocyte-restricted deletion of csk. Carcinogenesis. 2007;28:2074-81 pubmed
Guo J, Terhorst I, Stammer P, Ibrahim A, Oberhuber A, Eierhoff T. The short-chain fatty acid butyrate exerts a specific effect on VE-cadherin phosphorylation and alters the integrity of aortic endothelial cells. Front Cell Dev Biol. 2023;11:1076250 pubmed 出版商
Cheng N, Kim K, Lau L. Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2. JCI Insight. 2022;7: pubmed 出版商
Huang Y, Zhou B, Nabet A, Wernig M, Sudhof T. Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk. J Neurosci. 2019;39:7408-7427 pubmed 出版商
Hughes V, Siemann D. Treatment with Src inhibitor Dasatinib results in elevated metastatic potential in the 4T1 murine mammary carcinoma model. Tumor Microenviron. 2018;1:30-36 pubmed 出版商
Bernard Trifilo J, Lim S, Hou S, Schlaepfer D, Ilic D. Analyzing FAK and Pyk2 in early integrin signaling events. Curr Protoc Cell Biol. 2006;Chapter 14:Unit 14.7 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
SRC单克隆抗体(184Q20)
目录# :
AHO1152
规格 :
100微克
价格 :
美国500
克隆性 :
单克隆
纯度 :
亲和色谱
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1-3 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
184Q20
抗体亚型 :
IgG1, kappa
储存 :
-20°C
描述 :
SRC is a non-receptor kinase involved in the regulation of growth and differentiation of eukaryotic cells. SRC associates with the cytoplasmic region of various cell surface receptors to facilitate signal transduction, and is also involved in cytoskeletal organization, cell cycle regulation, and apoptosis. In humans, the gene encoding SRC is present on chromosome 20. Activity of SRC is regulated by two tyrosine residues (Tyr 416 and Tyr527), and phosphorylation of these two sites have opposing effects. Phosphorylation of Tyr416 in the activation loop of the kinase domain upregulates enzyme activity while the phosphorylation of Tyr527 decreases enzyme activity. Mutations in the SRC gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been found thus far.
免疫原 :
Recombinant human c-Src expressed in E. coli.
格式 :
液体
应用w/稀释 :
Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1-3 µg/mL
别名 :
ASV; AW259666; csrc; c-Src; EC 2.7.10.2; Neuronal proto-oncogene tyrosine-protein kinase Src; non-tyrosine protein kinase; OTTHUMP00000174476; OTTHUMP00000174477; OTTHUMP00000174478; p60-Src; p60-Src-1; PP60C-SCR; pp60c-src; pp60src; pp60v-src; Proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; proto-oncogene tyrosine-protein kinase Src; Rous sarcoma oncogene; RP5-823N20.1; SDR; src; src oncogene; SRC proto-oncogene, non-receptor tyrosine kinase; SRC proto-oncogene, non-receptor tyrosine kinase L homeolog; SRC proto-oncogene, non-receptor tyrosine kinase S homeolog; src.L; src.S; SRC1; src-1; src1-A; src-a; src-b; THC6; transforming protein; tyrosine kinase pp60c-src; tyrosine protein kinase c-src; tyrosine protein kinase pp60-c-src; tyrosine-protein kinase SRC-1; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma viral oncogene; XELAEV_18046582mg; xsrc
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国