产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Janus激酶2单克隆抗体(691R5)
目录 :
AHO1352
规格 :
100微克
价格 :
美国430
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
691R5
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 12
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 1
Nespital T, van der Velden L, Mensinga A, van der Vaart E, Strous G. Fos-Zippered GH Receptor Cytosolic Tails Act as Jak2 Substrates and Signal Transducers. Mol Endocrinol. 2016;30:290-301 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Nespital T, Strous G. The Jak/STAT signaling pathway is downregulated at febrile temperatures. PLoS ONE. 2012;7:e49374 pubmed 出版商
  • 免疫细胞化学; 人类
Tao J, Oladimeji P, Rider L, Diakonova M. PAK1-Nck regulates cyclin D1 promoter activity in response to prolactin. Mol Endocrinol. 2011;25:1565-78 pubmed 出版商
  • 免疫沉淀; 人类; 图 3
  • 免疫印迹; 人类; 图 3
Putters J, da Silva Almeida A, van Kerkhof P, van Rossum A, Gracanin A, Strous G. Jak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptor. PLoS ONE. 2011;6:e14676 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 s2
Sakamoto K, Triplett A, Schuler L, Wagner K. Janus kinase 2 is required for the initiation but not maintenance of prolactin-induced mammary cancer. Oncogene. 2010;29:5359-69 pubmed 出版商
  • 免疫印迹; 小鼠; 1:200; 图 2
Berthier C, Zhang H, Schin M, Henger A, Nelson R, Yee B, et al. Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy. Diabetes. 2009;58:469-77 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Rider L, Shatrova A, Feener E, Webb L, Diakonova M. JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functions. J Biol Chem. 2007;282:30985-96 pubmed
Wang R, Wang Y, Liao G, Chen B, Panettieri R, Penn R, et al. Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling. iScience. 2022;25:103833 pubmed 出版商
Cortizo F, Pfaff D, Wirth A, Schlotterer A, Medert R, Morgenstern J, et al. The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136. Mol Metab. 2022;55:101406 pubmed 出版商
Li M, Gao J, Li D, Yin Y. CEP55 Promotes Cell Motility via JAK2?STAT3?MMPs Cascade in Hepatocellular Carcinoma. Cells. 2018;7: pubmed 出版商
Hammer A, Rider L, Oladimeji P, Cook L, Li Q, Mattingly R, et al. Tyrosyl phosphorylated PAK1 regulates breast cancer cell motility in response to prolactin through filamin A. Mol Endocrinol. 2013;27:455-65 pubmed 出版商
Rider L, Tao J, Snyder S, Brinley B, Lu J, Diakonova M. Adapter protein SH2B1beta cross-links actin filaments and regulates actin cytoskeleton. Mol Endocrinol. 2009;23:1065-76 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
Janus激酶2单克隆抗体(691R5)
目录# :
AHO1352
规格 :
100微克
价格 :
美国430
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Western Blot: Assay Dependent
物种 :
人类, 小鼠, 大鼠
克隆 :
691R5
抗体亚型 :
IgG2b, kappa
储存 :
-20°C
描述 :
Janus Activating Kinase 2 (JAK2) is a non-rececptor tyrosine kinase involved in various processes such as cell growth, development, differentiation, and histone modifications. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting this gene can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
免疫原 :
重组片段对应于人Janus激酶2在大肠杆菌中表达
格式 :
液体
应用w/稀释 :
Western Blot: Assay Dependent
别名 :
EC 2.7.10.2; Fd17; JAK 2; Jak2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国