产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
IL-6受体单克隆抗体(B-R6)
目录 :
AHR0061
规格 :
100微克
价格 :
美国446.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
B-R6
反应物种 :
人类
应用 :
酶联免疫吸附测定, 免疫组化, 中和反应, 免疫沉淀, 流式细胞仪, 免疫组化-冰冻切片, 抑制或激活实验
更多信息或购买 :
文章摘录数: 9
出版应用/物种/样本/稀释参考文献
  • 抑制或激活实验; 人类; 表 1
Sharma S, Nemeth E, Chen Y, Goodnough J, Huston A, Roodman G, et al. Involvement of hepcidin in the anemia of multiple myeloma. Clin Cancer Res. 2008;14:3262-7 pubmed 出版商
  • 抑制或激活实验; 人类
Thyrell L, Arulampalam V, Hjortsberg L, Farnebo M, Grander D, Pokrovskaja Tamm K. Interferon alpha induces cell death through interference with interleukin 6 signaling and inhibition of STAT3 activity. Exp Cell Res. 2007;313:4015-24 pubmed
  • 流式细胞仪; 人类; 图 1
Zancai P, Cariati R, Quaia M, Guidoboni M, Rizzo S, Boiocchi M, et al. Retinoic acid inhibits IL-6-dependent but not constitutive STAT3 activation in Epstein-Barr virus-immortalized B lymphocytes. Int J Oncol. 2004;25:345-55 pubmed
  • 流式细胞仪; 人类
Schoeler D, Grützkau A, Henz B, Küchler J, Kruger Krasagakis S. Interleukin-6 enhances whereas tumor necrosis factor alpha and interferons inhibit integrin expression and adhesion of human mast cells to extracellular matrix proteins. J Invest Dermatol. 2003;120:795-801 pubmed
  • 流式细胞仪; 人类; 图 2
Bank U, Reinhold D, Schneemilch C, Kunz D, Synowitz H, Ansorge S. Selective proteolytic cleavage of IL-2 receptor and IL-6 receptor ligand binding chains by neutrophil-derived serine proteases at foci of inflammation. J Interferon Cytokine Res. 1999;19:1277-87 pubmed
  • 酶联免疫吸附测定; 人类; 图 1
Gage J, Breen E, Echeverri A, Magpantay L, Kishimoto T, Miles S, et al. Human herpesvirus 8-encoded interleukin 6 activates HIV-1 in the U1 monocytic cell line. AIDS. 1999;13:1851-5 pubmed
Pringle S, Wang X, Verstappen G, Terpstra J, Zhang C, He A, et al. Salivary Gland Stem Cells Age Prematurely in Primary Sjögren's Syndrome. Arthritis Rheumatol. 2019;71:133-142 pubmed 出版商
Blechacz B, Smoot R, Bronk S, Werneburg N, Sirica A, Gores G. Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2. Hepatology. 2009;50:1861-70 pubmed 出版商
Vermes C, Jacobs J, Zhang J, Firneisz G, Roebuck K, Glant T. Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts. J Biol Chem. 2002;277:16879-87 pubmed
产品信息
产品类型 :
抗体
产品名称 :
IL-6受体单克隆抗体(B-R6)
目录# :
AHR0061
规格 :
100微克
价格 :
美国446.00
克隆性 :
单克隆
纯度 :
纯化
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, Neutralization: Assay-dependent
物种 :
人类
克隆 :
B-R6
抗体亚型 :
IgG1, kappa
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
免疫原 :
CHO cells transfected with cDNA corresponding to the gp80 IL-6 receptor gene.
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, Neutralization: Assay-dependent
别名 :
CD126;CD126抗原;gp80;IL-6受体;白细胞介素-6受体甲;IL-6受体甲链;IL-6受体亚单位甲;IL6Q;IL6R;IL-6R;IL-6R 1;IL-6R亚单位甲;IL6R1;IL-6R;Il6ra;IL-6RA;IL-6R;IL6RQ;ILN;白细胞介素;白细胞介素6受体;白细胞介素6受体, 甲;白细胞介素6受体亚单位甲;膜糖蛋白80;MGC104991
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国