产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
INSR乙单克隆抗体(CT-3)
目录 :
AHR0271
规格 :
500微升
价格 :
美国496.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
CT-3
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 12
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 小鼠; 图 2
Roudnicky F, Dieterich L, Poyet C, Buser L, Wild P, Tang D, et al. High expression of insulin receptor on tumour-associated blood vessels in invasive bladder cancer predicts poor overall and progression-free survival. J Pathol. 2017;242:193-205 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠; 4 ug/ml; 图 8
Aimé P, Hegoburu C, Jaillard T, Degletagne C, Garcia S, Messaoudi B, et al. A physiological increase of insulin in the olfactory bulb decreases detection of a learned aversive odor and abolishes food odor-induced sniffing behavior in rats. PLoS ONE. 2012;7:e51227 pubmed 出版商
  • 免疫印迹; 大鼠
Sharma N, Arias E, Sequea D, Cartee G. Preventing the calorie restriction-induced increase in insulin-stimulated Akt2 phosphorylation eliminates calorie restriction's effect on glucose uptake in skeletal muscle. Biochim Biophys Acta. 2012;1822:1735-40 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000; 图 3
Sequea D, Sharma N, Arias E, Cartee G. Calorie restriction enhances insulin-stimulated glucose uptake and Akt phosphorylation in both fast-twitch and slow-twitch skeletal muscle of 24-month-old rats. J Gerontol A Biol Sci Med Sci. 2012;67:1279-85 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2
Xiao Y, Sharma N, Arias E, Castorena C, Cartee G. A persistent increase in insulin-stimulated glucose uptake by both fast-twitch and slow-twitch skeletal muscles after a single exercise session by old rats. Age (Dordr). 2013;35:573-82 pubmed
  • 免疫印迹; 人类; 图 2
Kasuga K, Kaneko H, Nishizawa M, Onodera O, Ikeuchi T. Generation of intracellular domain of insulin receptor tyrosine kinase by gamma-secretase. Biochem Biophys Res Commun. 2007;360:90-6 pubmed
  • 酶联免疫吸附测定; 人类; 0.75 ug/ml
Garcia Echeverria C, Pearson M, Marti A, Meyer T, Mestan J, Zimmermann J, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004;5:231-9 pubmed
Hsieh M, Choe J, Gadhvi J, Kim Y, Arguez M, Palmer M, et al. p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Cell Rep. 2019;28:1860-1878.e9 pubmed 出版商
Al Koborssy D, Palouzier Paulignan B, Canova V, Thevenet M, Fadool D, Julliard A. Modulation of olfactory-driven behavior by metabolic signals: role of the piriform cortex. Brain Struct Funct. 2019;224:315-336 pubmed 出版商
Hopkins B, Pauli C, Du X, Wang D, Li X, Wu D, et al. Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature. 2018;560:499-503 pubmed 出版商
Corbin J, Bhaskar V, Goldfine I, Issafras H, Bedinger D, Lau A, et al. Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: a potential new approach for the treatment of hyperinsulinemic hypoglycemia. MAbs. 2014;6:262-72 pubmed 出版商
Dismukes R, Ghosh P, Creveling C, Daly J. Altered responsiveness of adenosine 3',5'-monophosphate-generating systems in rat cortical slices after lesions of the medial forebran bundle. Exp Neurol. 1975;49:725-35 pubmed
产品信息
产品类型 :
抗体
产品名称 :
INSR乙单克隆抗体(CT-3)
目录# :
AHR0271
规格 :
500微升
价格 :
美国496.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类, 小鼠
应用 :
ELISA: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 1:25-1:50
物种 :
人类, 小鼠
克隆 :
CT-3
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.
免疫原 :
Recombinant fragment including the C-terminal 100 amino acid residues of human insulin receptor.
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): Assay-Dependent, Western Blot: 1:25-1:50
别名 :
4932439J01Rik; CD220; CD220 beta; CD221; D630014A15Rik; HHF5; IGF-I receptor; Insr; Insulin receptor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR beta; IR-A; IR-B
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国