产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
p21单克隆抗体(HJ21)
目录 :
AHZ0422
规格 :
100微克
价格 :
美国500.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
HJ21
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 11
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 小鼠; 图 5b
Lee S, Park K, Lee G, Kim S, Song W, Kwon S, et al. Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss. Exp Mol Med. 2021;53:591-604 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
Suvorova I, Grigorash B, Chuykin I, Pospelova T, Pospelov V. G1 checkpoint is compromised in mouse ESCs due to functional uncoupling of p53-p21Waf1 signaling. Cell Cycle. 2016;15:52-63 pubmed 出版商
  • 免疫细胞化学; 人类; 1:100; 图 6
  • 免疫印迹; 人类; 1:5000; 图 4
Pospelova T, Bykova T, Zubova S, Katolikova N, Yartzeva N, Pospelov V. Rapamycin induces pluripotent genes associated with avoidance of replicative senescence. Cell Cycle. 2013;12:3841-51 pubmed 出版商
  • 免疫印迹; 小鼠; 1:50; 图 1
Romanov V, Bardin A, Zubova S, Bykova T, Pospelov V, Pospelova T. p21Waf1 is required for complete oncogenic transformation of mouse embryo fibroblasts by E1Aad5 and c-Ha-ras oncogenes. Biochimie. 2011;93:1408-14 pubmed 出版商
Xiang X, Zhu J, Zhang G, Ma Z, Livingston M, Dong Z. Proximal Tubule p53 in Cold Storage/Transplantation-Associated Kidney Injury and Renal Graft Dysfunction. Front Med (Lausanne). 2021;8:746346 pubmed 出版商
Häseli S, Deubel S, Jung T, Grune T, Ott C. Cardiomyocyte Contractility and Autophagy in a Premature Senescence Model of Cardiac Aging. Oxid Med Cell Longev. 2020;2020:8141307 pubmed 出版商
Persia F, Troncoso M, Rinaldini E, Simirgiotis M, Tapia A, Borquez J, et al. UHPLC-Q/Orbitrap/MS/MS fingerprinting and antitumoral effects of Prosopis strombulifera (LAM.) BENTH. queous extract on allograft colorectal and melanoma cancer models. Heliyon. 2020;6:e03353 pubmed 出版商
Attaallah A, Lenzi M, Marchionni S, Bincoletto G, Cocchi V, Croco E, et al. A pro longevity role for cellular senescence. GeroScience. 2019;: pubmed 出版商
Ohmine S, Salisbury J, Ingle J, Pettinato G, Haddox C, Haddad T, et al. Aurora-A overexpression is linked to development of aggressive teratomas derived from human iPS cells. Oncol Rep. 2018;39:1725-1730 pubmed 出版商
Hrzenjak A, Moinfar F, Kremser M, Strohmeier B, Petru E, Zatloukal K, et al. Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo. Mol Cancer. 2010;9:49 pubmed 出版商
Stead E, White J, Faast R, Conn S, Goldstone S, Rathjen J, et al. Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities. Oncogene. 2002;21:8320-33 pubmed
产品信息
产品类型 :
抗体
产品名称 :
p21单克隆抗体(HJ21)
目录# :
AHZ0422
规格 :
100微克
价格 :
美国500.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: Assay-dependent, Western Blot: 1-2 µg/mL
物种 :
人类, 小鼠, 大鼠
克隆 :
HJ21
抗体亚型 :
IgG1
储存 :
4° C
描述 :
Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.
免疫原 :
人类重组p21WAF1蛋白
格式 :
液体
应用w/稀释 :
Immunocytochemistry: Assay-dependent, Western Blot: 1-2 µg/mL
别名 :
Activating Fragment 1; CAP20; cdk inhibitor CIP1; cdk inhibitor CIP1 (p21); CDKI; CDK-interacting protein 1; CDK-interaction protein 1; Cdkn1; CDKN1A; CDNK1A; CIP1; Cip1); cyclin dependent kinase inhibitor 1A; cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A; Cyclin-dependent kinase inhibitor 1A (p21; cyclin-dependent kinase inhibitor 1A (P21); cyclin-dependent kinase inhibitor 1A (p21, Cip1); cyclin-dependent kinase inhibitor 1A variant 1; cyclin-dependent kinase inhibitor 1A variant 2; DNA synthesis inhibitor; MDA6; MDA-6; melanoma differentiation associated protein 6; melanoma differentiation-associated protein; Melanoma differentiation-associated protein 6; OTTHUMP00000016298; p21; p21 ; p21Cip1; p21Cip1/Waf1; p21WAF; PIC1; putative cyclin-dependent kinase inhibitor 1A (p21/WAF1/CIP1); SDI1; SLC12A9; UV96; WAF1; Wild type p53 activated fragment 1 (WAF1); wild-type p53-activated fragment 1
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国