产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
ELISA/assay
产品名称 :
人类APE1/APEX1酶联免疫吸附试剂盒
目录 :
EH32RB
规格 :
96试验
价格 :
594.00美元
更多信息或购买 :
产品信息
产品类型 :
酶联免疫吸附测定
目录号 :
EH32RB
类别 :
酶联免疫吸附试剂盒
靶标 :
APE1
产品名称 :
人类APE1/APEX1酶联免疫吸附试剂盒
描述 :
Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional, bipartite enzyme that plays an important role in numerous, cellular functions. APE is responsible for repairing abasic sites in DNA and in regulating the redox state of other proteins that play roles in oxidative signaling, transcription factor regulation (Fos, Jun, NF-kB, Myb, HIF-1 alpha, CREB, Pax), cell cycle control (p53), and apoptosis. The most common form of DNA damage is the creation of abasic sites which are brought about through spontaneous loss or oxidative DNA damage, through chemically initiated hydrolysis (chemotherapy), ionizing radiation, UV irradiation, oxidizing agents, and removal of modified bases by DNA glycosylases. APE is differentially expressed during development and in different tissues. This protein has diverse subcellular localization patterns which support the possibility of its interaction with numerous, other cellular proteins in addition to DNA repair within the nucleus. Regulation of APE by phosphorylation is mediated, at least in part, by casein kinase II. Increases in APE message and protein levels are observed upon the reintroduction of oxygen to hypoxic cells, and in some malignant tissue relative to normal tissue. Decreases in APE expression have been associated with the induction of cellular apoptosis.
同义词 :
AP endonuclease 1; AP endonuclease class I; AP lyase; APE; APE1; APEN; Apex; APEX nuclease; APEX nuclease (multifunctional DNA repair enzyme) 1; APEX nuclease 1; APEX1; apurinic/a; Apurinic/apy; apurinic/apyrimidinic (abasic) endonuclease; apurinic/apyrimidinic endodeoxyribonuclease 1; apurinic/apyrimidinic endonuclease 1; Apurinic-apyrimidinic endonuclease 1; APX; deoxyribonuclease (apurinic or apyrimidinic); DNA-(apurinic or apyrimidinic site) lyase; DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; HAP1; LOC100348924; protein REF-1; redox factor 1; redox factor-1; REF1; REF-1
价格(美元) :
594.00美元
规格 :
96试验
物种活性 :
人类
应用 :
酶联免疫吸附测定
储存 :
2-8°C
检测范围 :
0.23-50 ng/mL
样品类型 :
Plasma, 50 µL Serum, 50 µL Supernatant, 50 µL
Assay Length :
1小时20分钟
提示 :
This product is for research use only.
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国