产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
TCR beta Monoclonal Antibody (H57-597), Alexa Fluor™ 647
目录 :
HM3621
规格 :
1毫升
价格 :
美国296.00
克隆性 :
单克隆
宿主 :
仓鼠
共轭标签 :
AF647
克隆名称 :
H57-597
反应物种 :
小鼠
应用 :
免疫细胞化学, 流式细胞仪
更多信息或购买 :
文章摘录数: 3
出版应用/物种/样本/稀释 | 参考文献 |
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产品信息
产品类型 :
抗体
产品名称 :
TCR beta Monoclonal Antibody (H57-597), Alexa Fluor™ 647
目录# :
HM3621
规格 :
1毫升
价格 :
美国296.00
克隆性 :
单克隆
纯度 :
纯化
宿主 :
亚美尼亚仓鼠
反应物种 :
小鼠
应用 :
Flow Cytometry: Assay-dependent
物种 :
小鼠
克隆 :
H57-597
抗体亚型 :
IgG
储存 :
4° C
描述 :
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
免疫原 :
TCR亲和纯化来自小鼠T细胞杂交瘤细胞DO-11.101
格式 :
液体
应用w/稀释 :
Flow Cytometry: Assay-dependent
别名 :
bTCR; FLJ22602; MGC117436; MGC22624; MGC23964; MGC71411; T cell receptor beta chain; t-cell antigen receptor; T-cell receptor; TCR beta; Tcra; Tcrb; TCRbeta; TCRD; Tib; TRA
更多信息或购买 :
公司信息
赛默飞世尔
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