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African green monkey, 人类, 小鼠, 大鼠, roundworm
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免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, 免疫组化-冰冻切片
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文章摘录数: 310
  • 免疫细胞化学; 小鼠; 图 s4q
  • 免疫印迹; 小鼠; 图 s3d
Swarnkar S, Avchalumov Y, Espadas I, Grinman E, Liu X, Raveendra B, et al. Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation. Cell Rep. 2021;36:109369 pubmed 出版商
  • 免疫组化; 大鼠; 图 4a
Doré K, Carrico Z, Alfonso S, Marino M, Koymans K, Kessels H, et al. PSD-95 protects synapses from β-amyloid. Cell Rep. 2021;35:109194 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:500; 图 s4j
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, et al. Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease. Sci Adv. 2020;6: pubmed 出版商
  • 免疫印迹; 小鼠; 1:300; 图 1d
Chen C, Soto G, Dumrongprechachan V, BANNON N, Kang S, Kozorovitskiy Y, et al. Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations. elife. 2020;9: pubmed 出版商
  • 免疫组化; 人类; 1:200; 图 2d
Zhong X, Harris G, Smirnova L, Zufferey V, Sá R, Baldino Russo F, et al. Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model. Front Cell Neurosci. 2020;14:25 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5a
Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 1:200; 图 5c
  • 免疫印迹; 小鼠; 1:200; 图 5a
di Meco A, Pratico D. Early-life exposure to high-fat diet influences brain health in aging mice. Aging Cell. 2019;18:e13040 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 1d
  • 免疫印迹; 小鼠; 图 s1j
Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, et al. Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. Science. 2019;363: pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:500; 图 s2g
Tanabe Y, Naito Y, Vasuta C, Lee A, Soumounou Y, Linhoff M, et al. IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2?. Nat Commun. 2017;8:408 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2a
Wilkinson B, Li J, Coba M. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Sci Rep. 2017;7:5272 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1a
Frank R, Zhu F, Komiyama N, Grant S. Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes. J Neurochem. 2017;142:504-511 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2d
Bobo Jiménez V, Delgado Esteban M, Angibaud J, Sánchez Morán I, de la Fuente A, Yajeya J, et al. APC/CCdh1-Rock2 pathway controls dendritic integrity and memory. Proc Natl Acad Sci U S A. 2017;114:4513-4518 pubmed 出版商
  • 免疫组化; 小鼠; 图 5c
  • 免疫印迹; 小鼠; 图 5a
Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:200; 图 3e
  • 免疫印迹; 大鼠; 1:2000; 图 3b
Behnke J, Cheedalla A, Bhatt V, Bhat M, Teng S, Palmieri A, et al. Neuropeptide VGF Promotes Maturation of Hippocampal Dendrites That Is Reduced by Single Nucleotide Polymorphisms. Int J Mol Sci. 2017;18: pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:150; 图 5e
Ripamonti S, Ambrozkiewicz M, Guzzi F, Gravati M, Biella G, Bormuth I, et al. Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons. elife. 2017;6: pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:500; 图 4a
Zhu G, Briz V, Seinfeld J, Liu Y, Bi X, Baudry M. Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction. Sci Rep. 2017;7:42788 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:1000; 图 6f
Kim S, Im S, Oh S, Jeong S, Yoon E, Lee C, et al. Anisotropically organized three-dimensional culture platform for reconstruction of a hippocampal neural network. Nat Commun. 2017;8:14346 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s1b
Ugun Klusek A, Tatham M, Elkharaz J, Constantin Teodosiu D, Lawler K, Mohamed H, et al. Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway. Cell Death Dis. 2017;8:e2531 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4b
Sabanov V, Braat S, D Andrea L, Willemsen R, Zeidler S, Rooms L, et al. Impaired GABAergic inhibition in the hippocampus of Fmr1 knockout mice. Neuropharmacology. 2017;116:71-81 pubmed 出版商
  • 免疫印迹; 大鼠; 1:800; 图 5a
Marco E, Ballesta J, Irala C, Hernández M, Serrano M, Mela V, et al. Sex-dependent influence of chronic mild stress (CMS) on voluntary alcohol consumption; study of neurobiological consequences. Pharmacol Biochem Behav. 2017;152:68-80 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 4a
Begum A, Aguilar J, Elias L, Hong Y. Silver nanoparticles exhibit coating and dose-dependent neurotoxicity in glutamatergic neurons derived from human embryonic stem cells. Neurotoxicology. 2016;57:45-53 pubmed 出版商
  • 免疫组化-冰冻切片; 大鼠; 图 4b
Wang W, Trieu B, Palmer L, Jia Y, Pham D, Jung K, et al. A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation. Eneuro. 2016;3: pubmed 出版商
  • 免疫细胞化学; 大鼠; 图 3
Li Y, Chang L, Song Y, Gao X, Roselli F, Liu J, et al. Astrocytic GluN2A and GluN2B Oppose the Synaptotoxic Effects of Amyloid-?1-40 in Hippocampal Cells. J Alzheimers Dis. 2016;54:135-48 pubmed 出版商
  • 免疫组化; 大鼠; 1:1000; 图 1a
Wang W, Kantorovich S, Babayan A, Hou B, Gall C, Lynch G. Estrogen's Effects on Excitatory Synaptic Transmission Entail Integrin and TrkB Transactivation and Depend Upon ?1-integrin function. Neuropsychopharmacology. 2016;41:2723-32 pubmed 出版商
  • 免疫印迹; 大鼠; 图 2
  • 免疫印迹; 小鼠; 1:1000; 图 s4
Reinhard J, Kriz A, Galic M, Angliker N, Rajalu M, Vogt K, et al. The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory. Nat Commun. 2016;7:11613 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:200; 图 3
Gibon J, Unsain N, Gamache K, Thomas R, de León A, Johnstone A, et al. The X-linked inhibitor of apoptosis regulates long-term depression and learning rate. FASEB J. 2016;30:3083-90 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:50; 图 2
Xia M, Zhu S, Shevelkin A, Ross C, Pletnikov M. DISC1, astrocytes and neuronal maturation: a possible mechanistic link with implications for mental disorders. J Neurochem. 2016;138:518-24 pubmed 出版商
  • 免疫印迹; 小鼠; 1:5000; 图 6
Matchynski Franks J, Susick L, Schneider B, Perrine S, Conti A. Impaired Ethanol-Induced Sensitization and Decreased Cannabinoid Receptor-1 in a Model of Posttraumatic Stress Disorder. PLoS ONE. 2016;11:e0155759 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 图 4
Park J, Yu Y, Zhou C, Li K, Wang D, Chang E, et al. Central Mechanisms Mediating Thrombospondin-4-induced Pain States. J Biol Chem. 2016;291:13335-48 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:1000; 图 3
Buren C, Tu G, Parsons M, Sepers M, Raymond L. Influence of cortical synaptic input on striatal neuronal dendritic arborization and sensitivity to excitotoxicity in corticostriatal coculture. J Neurophysiol. 2016;116:380-90 pubmed 出版商
  • 免疫印迹; 小鼠; 1:3000; 图 7
Frank R, Komiyama N, Ryan T, Zhu F, O Dell T, Grant S. NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation. Nat Commun. 2016;7:11264 pubmed 出版商
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Lauterborn J, Kramar E, Rice J, Babayan A, Cox C, Karsten C, et al. Cofilin Activation Is Temporally Associated with the Cessation of Growth in the Developing Hippocampus. Cereb Cortex. 2017;27:2640-2651 pubmed 出版商
  • 免疫细胞化学; 大鼠; 1:2000; 图 5
Kos A, Wanke K, Gioio A, Martens G, Kaplan B, Aschrafi A. Monitoring mRNA Translation in Neuronal Processes Using Fluorescent Non-Canonical Amino Acid Tagging. J Histochem Cytochem. 2016;64:323-33 pubmed 出版商
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Zhang Q, Gao X, Li C, Feliciano C, Wang D, Zhou D, et al. Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice. J Neurosci. 2016;36:2247-60 pubmed 出版商
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Kim G, Luján R, Schwenk J, Kelley M, Aguado C, Watanabe M, et al. Membrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel function. elife. 2016;5: pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:100; 图 4
Venugopalan P, Wang Y, Nguyen T, Huang A, Muller K, Goldberg J. Transplanted neurons integrate into adult retinas and respond to light. Nat Commun. 2016;7:10472 pubmed 出版商
  • 免疫沉淀; 人类; 图 5
  • 免疫印迹; 人类; 图 5
Wee K, Tan F, Cheong Y, Khanna S, Low C. Ontogenic Profile and Synaptic Distribution of GluN3 Proteins in the Rat Brain and Hippocampal Neurons. Neurochem Res. 2016;41:290-7 pubmed 出版商
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Mircsof D, Langouët M, Rio M, Moutton S, Siquier Pernet K, Bole Feysot C, et al. Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects. Nat Neurosci. 2015;18:1731-6 pubmed 出版商
  • 免疫组化; 人类; 图 2
Hjelm B, Rollins B, Mamdani F, Lauterborn J, Kirov G, Lynch G, et al. Evidence of Mitochondrial Dysfunction within the Complex Genetic Etiology of Schizophrenia. Mol Neuropsychiatry. 2015;1:201-19 pubmed 出版商
  • 免疫细胞化学; 小鼠; 图 4
Mayanagi T, Yasuda H, Sobue K. PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity. J Neurosci. 2015;35:14327-40 pubmed 出版商
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Briz V, Liu Y, Zhu G, Bi X, Baudry M. A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release. J Cell Biol. 2015;210:1225-37 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 4,5
Gingras S, Earls L, Howell S, Smeyne R, Zakharenko S, Pelletier S. SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015;35:10510-22 pubmed 出版商
  • 免疫印迹; 小鼠
Underhill S, Wheeler D, Amara S. Differential regulation of two isoforms of the glial glutamate transporter EAAT2 by DLG1 and CaMKII. J Neurosci. 2015;35:5260-70 pubmed 出版商
  • 免疫细胞化学; 小鼠; 1:2000; 图 1e
Thibault D, Giguère N, Loustalot F, Bourque M, Ducrot C, El Mestikawy S, et al. Homeostatic regulation of excitatory synapses on striatal medium spiny neurons expressing the D2 dopamine receptor. Brain Struct Funct. 2016;221:2093-107 pubmed 出版商
  • 免疫组化; roundworm
Von Stetina S, Mango S. PAR-6, but not E-cadherin and β-integrin, is necessary for epithelial polarization in C. elegans. Dev Biol. 2015;403:5-14 pubmed 出版商
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Briz V, Zhu G, Wang Y, Liu Y, Avetisyan M, Bi X, et al. Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity. J Neurosci. 2015;35:2269-82 pubmed 出版商
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Zhu G, Liu Y, Wang Y, Bi X, Baudry M. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways. J Neurosci. 2015;35:621-33 pubmed 出版商
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Zhu G, Li J, He L, Wang X, Hong X. MPTP-induced changes in hippocampal synaptic plasticity and memory are prevented by memantine through the BDNF-TrkB pathway. Br J Pharmacol. 2015;172:2354-68 pubmed 出版商
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Lee J, Lee E, Lee H. Hypothalamic, feeding/arousal-related peptidergic projections to the paraventricular thalamic nucleus in the rat. Brain Res. 2015;1598:97-113 pubmed 出版商
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Peng X, Hughes E, Moscato E, Parsons T, Dalmau J, Balice Gordon R. Cellular plasticity induced by anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis antibodies. Ann Neurol. 2015;77:381-98 pubmed 出版商
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Beccano Kelly D, Kuhlmann N, Tatarnikov I, Volta M, Munsie L, Chou P, et al. Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice. Front Cell Neurosci. 2014;8:301 pubmed 出版商
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Kang Y, Ge Y, Cassidy R, Lam V, Luo L, Moon K, et al. A combined transgenic proteomic analysis and regulated trafficking of neuroligin-2. J Biol Chem. 2014;289:29350-64 pubmed 出版商
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Whitfield D, Vallortigara J, Alghamdi A, Howlett D, Hortobagyi T, Johnson M, et al. Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment. Neurobiol Aging. 2014;35:2836-2844 pubmed 出版商
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Tyzack G, Sitnikov S, Barson D, Adams Carr K, Lau N, Kwok J, et al. Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression. Nat Commun. 2014;5:4294 pubmed 出版商
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Poguzhelskaya E, Artamonov D, Bolshakova A, Vlasova O, Bezprozvanny I. Simplified method to perform CLARITY imaging. Mol Neurodegener. 2014;9:19 pubmed 出版商
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Louros S, Hooks B, Litvina L, Carvalho A, Chen C. A role for stargazin in experience-dependent plasticity. Cell Rep. 2014;7:1614-1625 pubmed 出版商
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Nikitczuk J, Patil S, Matikainen Ankney B, Scarpa J, Shapiro M, Benson D, et al. N-cadherin regulates molecular organization of excitatory and inhibitory synaptic circuits in adult hippocampus in vivo. Hippocampus. 2014;24:943-962 pubmed 出版商
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Gomis Rüth S, Stiess M, Wierenga C, Meyn L, Bradke F. Single-cell axotomy of cultured hippocampal neurons integrated in neuronal circuits. Nat Protoc. 2014;9:1028-37 pubmed 出版商
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Maras P, Molet J, Chen Y, Rice C, Ji S, Solodkin A, et al. Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress. Mol Psychiatry. 2014;19:811-22 pubmed 出版商
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Gladding C, Fan J, Zhang L, Wang L, Xu J, Li E, et al. Alterations in STriatal-Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse model. J Neurochem. 2014;130:145-59 pubmed 出版商
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Colciaghi F, Finardi A, Nobili P, Locatelli D, Spigolon G, Battaglia G. Progressive brain damage, synaptic reorganization and NMDA activation in a model of epileptogenic cortical dysplasia. PLoS ONE. 2014;9:e89898 pubmed 出版商
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Aira Z, Buesa I, Rada D, Gomez Esteban J, Azkue J. Coupling of serotonergic input to NMDA receptor-phosphorylation following peripheral nerve injury via rapid, synaptic up-regulation of ND2. Exp Neurol. 2014;255:86-95 pubmed 出版商
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Cox C, Rex C, Palmer L, Babayan A, Pham D, Corwin S, et al. A map of LTP-related synaptic changes in dorsal hippocampus following unsupervised learning. J Neurosci. 2014;34:3033-41 pubmed 出版商
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del Pino I, Koch D, Schemm R, Qualmann B, Betz H, Paarmann I. Proteomic analysis of glycine receptor ? subunit (GlyR?)-interacting proteins: evidence for syndapin I regulating synaptic glycine receptors. J Biol Chem. 2014;289:11396-409 pubmed 出版商
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Itakura M, Watanabe I, Sugaya T, Takahashi M. Direct association of the unique C-terminal tail of transmembrane AMPA receptor regulatory protein ?-8 with calcineurin. FEBS J. 2014;281:1366-78 pubmed 出版商
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Wang Y, Zhu G, Briz V, Hsu Y, Bi X, Baudry M. A molecular brake controls the magnitude of long-term potentiation. Nat Commun. 2014;5:3051 pubmed 出版商
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Parsons M, Kang R, Buren C, Dau A, Southwell A, Doty C, et al. Bidirectional control of postsynaptic density-95 (PSD-95) clustering by Huntingtin. J Biol Chem. 2014;289:3518-28 pubmed 出版商
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Wang Y, Briz V, Chishti A, Bi X, Baudry M. Distinct roles for ?-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration. J Neurosci. 2013;33:18880-92 pubmed 出版商
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Dau A, Gladding C, Sepers M, Raymond L. Chronic blockade of extrasynaptic NMDA receptors ameliorates synaptic dysfunction and pro-death signaling in Huntington disease transgenic mice. Neurobiol Dis. 2014;62:533-42 pubmed 出版商
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Yam P, Pincus Z, Gupta G, Bashkurov M, Charron F, Pelletier L, et al. N-cadherin relocalizes from the periphery to the center of the synapse after transient synaptic stimulation in hippocampal neurons. PLoS ONE. 2013;8:e79679 pubmed 出版商
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Leuba G, Vernay A, Kraftsik R, Tardif E, Riederer B, Savioz A. Pathological reorganization of NMDA receptors subunits and postsynaptic protein PSD-95 distribution in Alzheimer's disease. Curr Alzheimer Res. 2014;11:86-96 pubmed
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Andres A, Regev L, Phi L, Seese R, Chen Y, Gall C, et al. NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH. J Neurosci. 2013;33:16945-60 pubmed 出版商
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Aujla P, Huntley G. Early postnatal expression and localization of matrix metalloproteinases-2 and -9 during establishment of rat hippocampal synaptic circuitry. J Comp Neurol. 2014;522:1249-63 pubmed 出版商
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Sowa Kucma M, Szewczyk B, Sadlik K, Piekoszewski W, Trela F, Opoka W, et al. Zinc, magnesium and NMDA receptor alterations in the hippocampus of suicide victims. J Affect Disord. 2013;151:924-31 pubmed 出版商
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Petoukhov E, Fernando S, Mills F, Shivji F, Hunter D, Krieger C, et al. Activity-dependent secretion of progranulin from synapses. J Cell Sci. 2013;126:5412-21 pubmed 出版商
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Wang X, Lippi G, Carlson D, Berg D. Activation of ?7-containing nicotinic receptors on astrocytes triggers AMPA receptor recruitment to glutamatergic synapses. J Neurochem. 2013;127:632-43 pubmed 出版商
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Aoto J, Martinelli D, Malenka R, Tabuchi K, Sudhof T. Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking. Cell. 2013;154:75-88 pubmed 出版商
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Alder J, Kallman S, Palmieri A, Khadim F, Ayer J, Kumar S, et al. Neuropeptide orphanin FQ inhibits dendritic morphogenesis through activation of RhoA. Dev Neurobiol. 2013;73:769-84 pubmed 出版商
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Cho K, Haque M, Wang J, Yu M, Hao Y, Qiu S, et al. Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors. PLoS Genet. 2013;9:e1003555 pubmed 出版商
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Finardi A, Colciaghi F, Castana L, Locatelli D, Marras C, Nobili P, et al. Long-duration epilepsy affects cell morphology and glutamatergic synapses in type IIB focal cortical dysplasia. Acta Neuropathol. 2013;126:219-35 pubmed 出版商
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Zabouri N, Haverkamp S. Calcium channel-dependent molecular maturation of photoreceptor synapses. PLoS ONE. 2013;8:e63853 pubmed 出版商
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Weng L, Lin Y, Li A, Wang C, Yan S, Sun M, et al. Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation. J Neurosci. 2013;33:8172-84 pubmed 出版商
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Yoshioka T, Hagiwara A, Hida Y, Ohtsuka T. Vangl2, the planar cell polarity protein, is complexed with postsynaptic density protein PSD-95 [corrected]. FEBS Lett. 2013;587:1453-9 pubmed 出版商
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Vogel Ciernia A, Matheos D, Barrett R, Kramar E, Azzawi S, Chen Y, et al. The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nat Neurosci. 2013;16:552-61 pubmed 出版商
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Oh J, Kwon A, Jo A, Kim H, Goo Y, Lee J, et al. Activity-dependent synaptic localization of processing bodies and their role in dendritic structural plasticity. J Cell Sci. 2013;126:2114-23 pubmed 出版商
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Molica F, Burger F, Thomas A, Staub C, Tailleux A, Staels B, et al. Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation. J Lipid Res. 2013;54:1360-8 pubmed 出版商
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Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, et al. Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice. Glia. 2013;61:679-93 pubmed 出版商
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Pettem K, Yokomaku D, Takahashi H, Ge Y, Craig A. Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development. J Cell Biol. 2013;200:321-36 pubmed 出版商
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Mizuno M, Kato D, Kanamori T, Toyoda T, Suzuki T, Ojika K, et al. Phosphorylation of collapsin response mediator protein-2 regulates its localization and association with hippocampal cholinergic neurostimulating peptide precursor in the hippocampus. Neurosci Lett. 2013;535:122-7 pubmed 出版商
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Borlikova G, Trejo M, Mably A, Mc Donald J, Sala Frigerio C, Regan C, et al. Alzheimer brain-derived amyloid ?-protein impairs synaptic remodeling and memory consolidation. Neurobiol Aging. 2013;34:1315-27 pubmed 出版商
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Tanokashira D, Morita T, Hayashi K, Mayanagi T, Fukumoto K, Kubota Y, et al. Glucocorticoid suppresses dendritic spine development mediated by down-regulation of caldesmon expression. J Neurosci. 2012;32:14583-91 pubmed 出版商
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Aira Z, Buesa I, Gallego M, Garcia del Caño G, Mendiable N, Mingo J, et al. Time-dependent cross talk between spinal serotonin 5-HT2A receptor and mGluR1 subserves spinal hyperexcitability and neuropathic pain after nerve injury. J Neurosci. 2012;32:13568-81 pubmed
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Babayan A, Kramar E, Barrett R, Jafari M, Haettig J, Chen L, et al. Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation. J Neurosci. 2012;32:12854-61 pubmed 出版商
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Maas C, Torres V, Altrock W, Leal Ortiz S, Wagh D, Terry Lorenzo R, et al. Formation of Golgi-derived active zone precursor vesicles. J Neurosci. 2012;32:11095-108 pubmed 出版商
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Fuentes F, Zimmer D, Atienza M, Schottenfeld J, Penkala I, BALE T, et al. Protein tyrosine phosphatase PTP1B is involved in hippocampal synapse formation and learning. PLoS ONE. 2012;7:e41536 pubmed 出版商
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Carretón O, Giralt A, Torres Peraza J, Brito V, Lucas J, Gines S, et al. Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels. Exp Neurol. 2012;237:335-45 pubmed 出版商
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She K, Ferreira J, Carvalho A, Craig A. Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors. J Biol Chem. 2012;287:27432-45 pubmed 出版商
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Milnerwood A, Kaufman A, Sepers M, Gladding C, Zhang L, Wang L, et al. Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice. Neurobiol Dis. 2012;48:40-51 pubmed 出版商
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Lozada A, Wang X, Gounko N, Massey K, Duan J, Liu Z, et al. Glutamatergic synapse formation is promoted by ?7-containing nicotinic acetylcholine receptors. J Neurosci. 2012;32:7651-61 pubmed 出版商
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Okuno H, Akashi K, Ishii Y, Yagishita Kyo N, Suzuki K, Nonaka M, et al. Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKII?. Cell. 2012;149:886-98 pubmed 出版商
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Kato D, Mitake S, Mizuno M, Kanamori T, Suzuki T, Ojika K, et al. Co-localization of hippocampal cholinergic neurostimulating peptide precursor with collapsin response mediator protein-2 at presynaptic terminals in hippocampus. Neurosci Lett. 2012;517:92-7 pubmed 出版商
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Gladding C, Sepers M, Xu J, Zhang L, Milnerwood A, Lombroso P, et al. Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model. Hum Mol Genet. 2012;21:3739-52 pubmed 出版商
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Yadav R, Gupta S, Hillman B, Bhatt J, Stairs D, Dravid S. Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors. PLoS ONE. 2012;7:e32969 pubmed 出版商
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Chen Y, Kramár E, Chen L, Babayan A, Andres A, Gall C, et al. Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling. Mol Psychiatry. 2013;18:485-96 pubmed 出版商
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Matsui C, Inoue E, Kakita A, Arita K, Deguchi Tawarada M, Togawa A, et al. Involvement of the ?-secretase-mediated EphA4 signaling pathway in synaptic pathogenesis of Alzheimer's disease. Brain Pathol. 2012;22:776-87 pubmed 出版商
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Shibasaki M, Kurokawa K, Mizuno K, Suzuki T, Ohkuma S. Actin dynamics in development of behavioral sensitization after withdrawal from long-term ethanol administration to mice. Alcohol Clin Exp Res. 2012;36:1385-96 pubmed 出版商
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Wilke S, Hall B, Antonios J, DeNardo L, Otto S, Yuan B, et al. NeuroD2 regulates the development of hippocampal mossy fiber synapses. Neural Dev. 2012;7:9 pubmed 出版商
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Yamagata M, Sanes J. Transgenic strategy for identifying synaptic connections in mice by fluorescence complementation (GRASP). Front Mol Neurosci. 2012;5:18 pubmed 出版商
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Bagley E, Westbrook G. Short-term field stimulation mimics synaptic maturation of hippocampal synapses. J Physiol. 2012;590:1641-54 pubmed 出版商
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Ettorre M, Lorenzetto E, Laperchia C, Baiguera C, Branca C, Benarese M, et al. Glutamatergic neurons induce expression of functional glutamatergic synapses in primary myotubes. PLoS ONE. 2012;7:e31451 pubmed 出版商
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Andreae L, Fredj N, Burrone J. Independent vesicle pools underlie different modes of release during neuronal development. J Neurosci. 2012;32:1867-74 pubmed 出版商
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Peng X, Parsons T, Balice Gordon R. Determinants of synaptic strength vary across an axon arbor. J Neurophysiol. 2012;107:2430-41 pubmed 出版商
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Fan J, Gladding C, Wang L, Zhang L, Kaufman A, Milnerwood A, et al. P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease. Neurobiol Dis. 2012;45:999-1009 pubmed 出版商
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Batcha A, Greferath U, Jobling A, Vessey K, Ward M, Nithianantharajah J, et al. Retinal dysfunction, photoreceptor protein dysregulation and neuronal remodelling in the R6/1 mouse model of Huntington's disease. Neurobiol Dis. 2012;45:887-96 pubmed 出版商
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Briz V, Parkash J, Sánchez Redondo S, Prevot V, Suñol C. Allopregnanolone prevents dieldrin-induced NMDA receptor internalization and neurotoxicity by preserving GABA(A) receptor function. Endocrinology. 2012;153:847-60 pubmed 出版商
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Chen A, Gössling E, Witkowski L, Bhindi A, Bauch C, Roussy G, et al. Regional and subcellular distribution of the receptor-targeting protein PIST in the rat central nervous system. J Comp Neurol. 2012;520:889-913 pubmed 出版商
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She K, Craig A. NMDA receptors mediate synaptic competition in culture. PLoS ONE. 2011;6:e24423 pubmed 出版商
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Fan Y, Tang X, Vitriol E, Chen G, Zheng J. Actin capping protein is required for dendritic spine development and synapse formation. J Neurosci. 2011;31:10228-33 pubmed 出版商
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Ling W, Chang L, Song Y, Lu T, Jiang Y, Li Y, et al. Immunolocalization of NR1, NR2A, and PSD-95 in rat hippocampal subregions during postnatal development. Acta Histochem. 2012;114:285-95 pubmed 出版商
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Hiratsuka K, Momose A, Takagi N, Sasaki H, Yin S, Fujita M, et al. Neuronal expression, cytosolic localization, and developmental regulation of the organic solute carrier partner 1 in the mouse brain. Histochem Cell Biol. 2011;135:229-38 pubmed 出版商
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Hida Y, Fukaya M, Hagiwara A, Deguchi Tawarada M, Yoshioka T, Kitajima I, et al. Prickle2 is localized in the postsynaptic density and interacts with PSD-95 and NMDA receptors in the brain. J Biochem. 2011;149:693-700 pubmed 出版商
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Sumida G, Stamer W. S1P? receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology. Am J Physiol Cell Physiol. 2011;300:C1164-71 pubmed 出版商
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Takahashi H, Arstikaitis P, Prasad T, Bartlett T, Wang Y, Murphy T, et al. Postsynaptic TrkC and presynaptic PTP? function as a bidirectional excitatory synaptic organizing complex. Neuron. 2011;69:287-303 pubmed 出版商
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Sweet E, Previtera M, Fernandez J, Charych E, Tseng C, Kwon M, et al. PSD-95 alters microtubule dynamics via an association with EB3. J Neurosci. 2011;31:1038-47 pubmed 出版商
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Voulalas P, Schetz J, Undieh A. Differential subcellular distribution of rat brain dopamine receptors and subtype-specific redistribution induced by cocaine. Mol Cell Neurosci. 2011;46:645-54 pubmed 出版商
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Shioda N, Beppu H, Fukuda T, Li E, Kitajima I, Fukunaga K. Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain. J Neurosci. 2011;31:346-58 pubmed 出版商
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Ripley B, Otto S, Tiglio K, Williams M, Ghosh A. Regulation of synaptic stability by AMPA receptor reverse signaling. Proc Natl Acad Sci U S A. 2011;108:367-72 pubmed 出版商
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Citri A, Bhattacharyya S, Ma C, Morishita W, Fang S, Rizo J, et al. Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression. J Neurosci. 2010;30:16437-52 pubmed 出版商
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Chen L, Rex C, Pham D, Lynch G, Gall C. BDNF signaling during learning is regionally differentiated within hippocampus. J Neurosci. 2010;30:15097-101 pubmed 出版商
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Nassirpour R, Bahima L, Lalive A, Lüscher C, Lujan R, Slesinger P. Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons. J Neurosci. 2010;30:13419-30 pubmed 出版商
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Liu J, Chang L, Roselli F, Almeida O, Gao X, Wang X, et al. Amyloid-? induces caspase-dependent loss of PSD-95 and synaptophysin through NMDA receptors. J Alzheimers Dis. 2010;22:541-56 pubmed 出版商
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Fan J, Vasuta O, Zhang L, Wang L, George A, Raymond L. N-methyl-D-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95. J Neurochem. 2010;115:1045-56 pubmed 出版商
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Dodd J, Birch N, Waldvogel H, Christie D. Functional and immunocytochemical characterization of the creatine transporter in rat hippocampal neurons. J Neurochem. 2010;115:684-93 pubmed 出版商
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Chen L, Rex C, Babayan A, Kramar E, Lynch G, Gall C, et al. Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome. J Neurosci. 2010;30:10977-84 pubmed 出版商
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Borges V, Lee T, Christie D, Birch N. Neuroserpin regulates the density of dendritic protrusions and dendritic spine shape in cultured hippocampal neurons. J Neurosci Res. 2010;88:2610-7 pubmed 出版商
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Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I. Role of presenilins in neuronal calcium homeostasis. J Neurosci. 2010;30:8566-80 pubmed 出版商
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Delint Ramirez I, Fernández E, Bayés A, Kicsi E, Komiyama N, Grant S. In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93. J Neurosci. 2010;30:8162-70 pubmed 出版商
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Siddiqui T, Pancaroglu R, Kang Y, Rooyakkers A, Craig A. LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development. J Neurosci. 2010;30:7495-506 pubmed 出版商
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Oh J, Nam Y, Jo A, Cheon H, Rhee S, Park J, et al. Apolipoprotein E mRNA is transported to dendrites and may have a role in synaptic structural plasticity. J Neurochem. 2010;114:685-96 pubmed 出版商
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Uriu Y, Kiyonaka S, Miki T, Yagi M, Akiyama S, Mori E, et al. Rab3-interacting molecule gamma isoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels. J Biol Chem. 2010;285:21750-67 pubmed 出版商
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Jenkins M, Christel C, Jiao Y, Abiria S, Kim K, Usachev Y, et al. Ca2+-dependent facilitation of Cav1.3 Ca2+ channels by densin and Ca2+/calmodulin-dependent protein kinase II. J Neurosci. 2010;30:5125-35 pubmed 出版商
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Parkash J, d Anglemont de Tassigny X, Bellefontaine N, Campagne C, Mazure D, Buee Scherrer V, et al. Phosphorylation of N-methyl-D-aspartic acid receptor-associated neuronal nitric oxide synthase depends on estrogens and modulates hypothalamic nitric oxide production during the ovarian cycle. Endocrinology. 2010;151:2723-35 pubmed 出版商
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Chen L, Rex C, Sanaiha Y, Lynch G, Gall C. Learning induces neurotrophin signaling at hippocampal synapses. Proc Natl Acad Sci U S A. 2010;107:7030-5 pubmed 出版商
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Samudio Ruiz S, Allan A, Sheema S, Caldwell K. Hippocampal N-methyl-D-aspartate receptor subunit expression profiles in a mouse model of prenatal alcohol exposure. Alcohol Clin Exp Res. 2010;34:342-53 pubmed 出版商
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Han M, Lin C, Meng S, Wang X. Proteomics analysis reveals overlapping functions of clustered protocadherins. Mol Cell Proteomics. 2010;9:71-83 pubmed 出版商
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Hozumi Y, Watanabe M, Otani K, Goto K. Diacylglycerol kinase beta promotes dendritic outgrowth and spine maturation in developing hippocampal neurons. BMC Neurosci. 2009;10:99 pubmed 出版商
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Yang G, Xiong W, Kojic L, Cynader M. Subunit-selective palmitoylation regulates the intracellular trafficking of AMPA receptor. Eur J Neurosci. 2009;30:35-46 pubmed 出版商
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Gainey M, Hurvitz Wolff J, Lambo M, Turrigiano G. Synaptic scaling requires the GluR2 subunit of the AMPA receptor. J Neurosci. 2009;29:6479-89 pubmed 出版商
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Linhoff M, Lauren J, Cassidy R, Dobie F, Takahashi H, Nygaard H, et al. An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron. 2009;61:734-49 pubmed 出版商
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Xu X, Ye L, Ruan Q. Environmental enrichment induces synaptic structural modification after transient focal cerebral ischemia in rats. Exp Biol Med (Maywood). 2009;234:296-305 pubmed 出版商
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Jung J, Jung C, Choi H, Jun K, Yoo J, Kang S, et al. Diagnostic utility of expression of claudins in non-small cell lung cancer: different expression profiles in squamous cell carcinomas and adenocarcinomas. Pathol Res Pract. 2009;205:409-16 pubmed 出版商
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Soule J, Penke Z, Kanhema T, Alme M, Laroche S, Bramham C. Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins in the rat dentate gyrus. Neural Plast. 2008;2008:269097 pubmed 出版商
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d Anglemont de Tassigny X, Campagne C, Steculorum S, Prevot V. Estradiol induces physical association of neuronal nitric oxide synthase with NMDA receptor and promotes nitric oxide formation via estrogen receptor activation in primary neuronal cultures. J Neurochem. 2009;109:214-24 pubmed 出版商
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Peng Y, He S, Marie H, Zeng S, Ma J, Tan Z, et al. Coordinated changes in dendritic arborization and synaptic strength during neural circuit development. Neuron. 2009;61:71-84 pubmed 出版商
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Lauterborn J, Pineda E, Chen L, Ramirez E, Lynch G, Gall C. Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression. Neuroscience. 2009;159:283-95 pubmed 出版商
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Hozumi Y, Fukaya M, Adachi N, Saito N, Otani K, Kondo H, et al. Diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum. Eur J Neurosci. 2008;28:2409-22 pubmed 出版商
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McKellar C, Shatz C. Synaptogenesis in purified cortical subplate neurons. Cereb Cortex. 2009;19:1723-37 pubmed 出版商
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Lai K, Zhao Y, Ch ng T, Martin K. Importin-mediated retrograde transport of CREB2 from distal processes to the nucleus in neurons. Proc Natl Acad Sci U S A. 2008;105:17175-80 pubmed 出版商
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Aoto J, Nam C, Poon M, Ting P, Chen L. Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity. Neuron. 2008;60:308-20 pubmed 出版商
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Leuba G, Savioz A, Vernay A, Carnal B, Kraftsik R, Tardif E, et al. Differential changes in synaptic proteins in the Alzheimer frontal cortex with marked increase in PSD-95 postsynaptic protein. J Alzheimers Dis. 2008;15:139-51 pubmed
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Morice E, Andreae L, Cooke S, Vanes L, Fisher E, Tybulewicz V, et al. Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome. Learn Mem. 2008;15:492-500 pubmed 出版商
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Henny P, Jones B. Projections from basal forebrain to prefrontal cortex comprise cholinergic, GABAergic and glutamatergic inputs to pyramidal cells or interneurons. Eur J Neurosci. 2008;27:654-70 pubmed 出版商
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Xu W, Schlüter O, Steiner P, Czervionke B, Sabatini B, Malenka R. Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD. Neuron. 2008;57:248-62 pubmed 出版商
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Lacroix Fralish M, Tawfik V, Nutile McMenemy N, Harris B, DeLeo J. Differential regulation of neuregulin 1 expression by progesterone in astrocytes and neurons. Neuron Glia Biol. 2006;2:227-34 pubmed
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Kioussi C, Appu M, LOHR C, Fischer K, Bajaj G, Leid M, et al. Co-expression of myosin II regulatory light chain and the NMDAR1 subunit in neonatal and adult mouse brain. Brain Res Bull. 2007;74:439-51 pubmed
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Aoto J, Ting P, Maghsoodi B, Xu N, Henkemeyer M, Chen L. Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation. J Neurosci. 2007;27:7508-19 pubmed
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Khurana R, Devaud L. Sex differences in neurotransmission parameters in response to repeated mild restraint stress exposures in intact male, female and ovariectomised female rats. J Neuroendocrinol. 2007;19:511-20 pubmed
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图像 1 :
赛默飞世尔 MA1-045 图像 1
Immunofluorescent analysis of PSD95 using PSD95 Monoclonal antibody (6G6-1C9) (Product# MA1-045) shows staining in HeLa cells. PSD95 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing PSD95 (Product# MA1-045) at a dilution of 1:100-1:200 over night at 4 ?C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product# 35552 for GAR, Product# 35503 for GAM). Images were taken at 60X magnification.
图像 2 :
赛默飞世尔 MA1-045 图像 2
Immunofluorescent analysis of PSD95 using PSD95 Monoclonal antibody (6G6-1C9) (Product# MA1-045) shows staining in U251 glioma cells. PSD95 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing PSD95 (Product# MA1-045) at a dilution of 1:100-1:200 over night at 4 ?C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product# 35552 for GAR, Product# 35503 for GAM). Images were taken at 60X magnification.
图像 3 :
赛默飞世尔 MA1-045 图像 3
Immunofluorescent analysis of PSD95 using PSD95 Monoclonal antibody (6G6-1C9) (Product# MA1-045) shows staining in C6 glioma cells. PSD95 staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing PSD95 (Product# MA1-045) at a dilution of 1:100-1:200 over night at 4 ?C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product# 35552 for GAR, Product# 35503 for GAM). Images were taken at 60X magnification.
产品类型 :
产品名称 :
目录# :
规格 :
价格 :
克隆性 :
纯度 :
宿主 :
反应物种 :
人类, 小鼠, 大鼠
应用 :
Flow Cytometry: 2 µg/test, Immunocytochemistry: 1:500, Immunoprecipitation: Assay-dependent, Western Blot: 1:2,000
物种 :
人类, 小鼠, 大鼠
克隆 :
抗体亚型 :
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is one of a family of membrane-associated proteins found in the postsynaptic density in forebrain neurons and certain presynaptic structures in the cerebellum. Like other members of the family, PSD-95 has three 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. PSD-95 is believed to participate in the clustering of certain proteins, including NMDA receptors, Shaker-type potassium channels at the synaptic membrane in central nervous system (CNS) neurons. There are two principal modes of interaction between PSD-95 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits), and some of these proteins may interact with PSD-95 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-95 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
免疫原 :
格式 :
应用w/稀释 :
Flow Cytometry: 2 µg/test, Immunocytochemistry: 1:500, Immunoprecipitation: Assay-dependent, Western Blot: 1:2,000
别名 :
discs large homolog 4; discs large MAGUK scaffold protein 4; discs, large homolog 4; discs, large homolog 4 (Drosophila); disks large homolog 4; Dlg4; Dlgh4; FLJ97752; FLJ98574; post synaptic density; postsynaptic density protein 95; post-synaptic density protein 95; PSD95; PSD-95; PSD-95 alpha 2b; PSD-95 beta; Sap90; SAP-90; SAP90A; Synapse-associated protein 90; synapse-associated protein SAP90; Tax interaction protein 15
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公司总部: 美国