产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
磷酸化CaMKII甲(Thr286)单克隆抗体(22B1)
目录 :
MA1-047
规格 :
100微升
价格 :
美国412.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
抗原修饰 :
磷酸化
克隆名称 :
22B1
反应物种 :
人类, 小鼠, 大鼠, domestic rabbit
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 76
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 1:1000; 图 ev2a, 5b
Bella P, Farini A, Banfi S, Parolini D, Tonna N, Meregalli M, et al. Blockade of IGF2R improves muscle regeneration and ameliorates Duchenne muscular dystrophy. EMBO Mol Med. 2020;12:e11019 pubmed 出版商
  • 免疫印迹; 大鼠; 图 3a
Sanchez Alonso J, Bhargava A, O HARA T, Glukhov A, Schobesberger S, Bhogal N, et al. Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart Failure. Circ Res. 2016;119:944-55 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 7
Farini A, Sitzia C, Cassinelli L, Colleoni F, Parolini D, Giovanella U, et al. Inositol 1,4,5-trisphosphate (IP3)-dependent Ca2+ signaling mediates delayed myogenesis in Duchenne muscular dystrophy fetal muscle. Development. 2016;143:658-69 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5f
Guilbert A, Lim H, Cheng J, Wang Y. CaMKII-dependent myofilament Ca2+ desensitization contributes to the frequency-dependent acceleration of relaxation. Cell Calcium. 2015;58:489-99 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000-4000
Pasek J, Wang X, Colbran R. Differential CaMKII regulation by voltage-gated calcium channels in the striatum. Mol Cell Neurosci. 2015;68:234-43 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Ermolova N, Martinez L, Vetrone S, Jordan M, Roos K, Sweeney H, et al. Long-term administration of the TNF blocking drug Remicade (cV1q) to mdx mice reduces skeletal and cardiac muscle fibrosis, but negatively impacts cardiac function. Neuromuscul Disord. 2014;24:583-95 pubmed 出版商
  • 免疫组化; 小鼠; 1:2000
  • 免疫印迹; 小鼠; 1:2000
Prévilon M, Pezet M, Vinet L, Mercadier J, Rouet Benzineb P. Gender-specific potential inhibitory role of Ca2+/calmodulin dependent protein kinase phosphatase (CaMKP) in pressure-overloaded mouse heart. PLoS ONE. 2014;9:e90822 pubmed 出版商
  • 免疫印迹; 小鼠
Chang A, Huang J, Battiprolu P, Hill J, Kamm K, Stull J. The effects of neuregulin on cardiac Myosin light chain kinase gene-ablated hearts. PLoS ONE. 2013;8:e66720 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Alzoubi K, Srivareerat M, Aleisa A, Alkadhi K. Chronic caffeine treatment prevents stress-induced LTP impairment: the critical role of phosphorylated CaMKII and BDNF. J Mol Neurosci. 2013;49:11-20 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Zeng Y, Lv F, Li L, Yu H, Dong M, Fu Q. 7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats. J Neurochem. 2012;122:800-11 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Iio W, Matsukawa N, Tsukahara T, Toyoda A. The effects of oral taurine administration on behavior and hippocampal signal transduction in rats. Amino Acids. 2012;43:2037-46 pubmed 出版商
  • 免疫印迹; 小鼠
Carlisle H, Luong T, Medina Marino A, Schenker L, Khorosheva E, Indersmitten T, et al. Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction. J Neurosci. 2011;31:16194-207 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000
Prévilon M, Pezet M, Semprez F, Mercadier J, Rouet Benzineb P. FKBP12.6 mice display temporal gender differences in cardiac Ca(2+)-signalling phenotype upon chronic pressure overload. Can J Physiol Pharmacol. 2011;89:769-82 pubmed 出版商
  • 免疫印迹; domestic rabbit
Sag C, Köhler A, Anderson M, Backs J, Maier L. CaMKII-dependent SR Ca leak contributes to doxorubicin-induced impaired Ca handling in isolated cardiac myocytes. J Mol Cell Cardiol. 2011;51:749-59 pubmed 出版商
  • 免疫组化-冰冻切片; 小鼠; 1:100
  • 免疫组化; 小鼠; 1:100
  • 免疫印迹; 小鼠; 1:2000
Mouton Liger F, Thomas S, Rattenbach R, Magnol L, Larigaldie V, Ledru A, et al. PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-? activation in mouse models of Down syndrome. J Comp Neurol. 2011;519:2779-802 pubmed 出版商
  • 免疫印迹; 小鼠
Huke S, DeSantiago J, Kaetzel M, Mishra S, BROWN J, Dedman J, et al. SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδC. J Mol Cell Cardiol. 2011;50:230-8 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Musazzi L, Di Daniel E, Maycox P, Racagni G, Popoli M. Abnormalities in ?/?-CaMKII and related mechanisms suggest synaptic dysfunction in hippocampus of LPA1 receptor knockout mice. Int J Neuropsychopharmacol. 2011;14:941-53 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Wang Y, Huang C, Hsu K. The role of growth retardation in lasting effects of neonatal dexamethasone treatment on hippocampal synaptic function. PLoS ONE. 2010;5:e12806 pubmed 出版商
  • 免疫印迹; 大鼠; 1:5000
Perreault M, Hasbi A, Alijaniaram M, Fan T, Varghese G, Fletcher P, et al. The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia. J Biol Chem. 2010;285:36625-34 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2500
Fumagalli F, Caffino L, Vogt M, Frasca A, Racagni G, Sprengel R, et al. AMPA GluR-A receptor subunit mediates hippocampal responsiveness in mice exposed to stress. Hippocampus. 2011;21:1028-35 pubmed 出版商
  • 免疫印迹; 小鼠
Jenkins M, Christel C, Jiao Y, Abiria S, Kim K, Usachev Y, et al. Ca2+-dependent facilitation of Cav1.3 Ca2+ channels by densin and Ca2+/calmodulin-dependent protein kinase II. J Neurosci. 2010;30:5125-35 pubmed 出版商
  • 免疫印迹; 小鼠
Yin J, Yang R, Li S, Renshaw A, Li Y, Schultz H, et al. Mitochondria-produced superoxide mediates angiotensin II-induced inhibition of neuronal potassium current. Am J Physiol Cell Physiol. 2010;298:C857-65 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Neef S, Dybkova N, Sossalla S, Ort K, Fluschnik N, Neumann K, et al. CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation. Circ Res. 2010;106:1134-44 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Musazzi L, Mallei A, Tardito D, Gruber S, El Khoury A, Racagni G, et al. Early-life stress and antidepressant treatment involve synaptic signaling and Erk kinases in a gene-environment model of depression. J Psychiatr Res. 2010;44:511-20 pubmed 出版商
  • 免疫印迹; 小鼠
Zhang T, Guo T, Mishra S, Dalton N, Kranias E, Peterson K, et al. Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res. 2010;106:354-62 pubmed 出版商
  • 免疫印迹; 大鼠; 1:2500
Magnaghi V, Parducz A, Frasca A, Ballabio M, Procacci P, Racagni G, et al. GABA synthesis in Schwann cells is induced by the neuroactive steroid allopregnanolone. J Neurochem. 2010;112:980-90 pubmed 出版商
  • 免疫沉淀; 大鼠
Nikandrova Y, Jiao Y, Baucum A, Tavalin S, Colbran R. Ca2+/calmodulin-dependent protein kinase II binds to and phosphorylates a specific SAP97 splice variant to disrupt association with AKAP79/150 and modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPAR) activ. J Biol Chem. 2010;285:923-34 pubmed 出版商
  • 免疫印迹; 大鼠
Abiria S, Colbran R. CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation. J Neurochem. 2010;112:150-61 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Ng J, Rashid A, So C, O Dowd B, George S. Activation of calcium/calmodulin-dependent protein kinase IIalpha in the striatum by the heteromeric D1-D2 dopamine receptor complex. Neuroscience. 2010;165:535-41 pubmed 出版商
  • 免疫印迹; 大鼠; 1:200
Lucic V, Greif G, Kennedy M. Detailed state model of CaMKII activation and autophosphorylation. Eur Biophys J. 2008;38:83-98 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Alzoubi K, Aleisa A, Alkadhi K. In vivo expression of ganglionic long-term potentiation in superior cervical ganglia from hypertensive aged rats. Neurobiol Aging. 2010;31:805-12 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Alzoubi K, Aleisa A, Alkadhi K. Effect of chronic stress or nicotine on hypothyroidism-induced enhancement of LTD: electrophysiological and molecular studies. Neurobiol Dis. 2008;32:81-7 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Alzoubi K, Aleisa A, Alkadhi K. Expression of gLTP in sympathetic ganglia from stress-hypertensive rats: molecular evidence. J Mol Neurosci. 2008;35:201-9 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000
Zhou Y, Takahashi E, Li W, Halt A, Wiltgen B, Ehninger D, et al. Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning. J Neurosci. 2007;27:13843-53 pubmed
  • 免疫印迹; 大鼠; 1:2000
Maj P, Collu M, Fadda P, Cattaneo A, Racagni G, Riva M. Long-term reduction of brain-derived neurotrophic factor levels and signaling impairment following prenatal treatment with the cannabinoid receptor 1 receptor agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinyl-methyl) pyrrolo[1,2,3-de]-1,4-benzox. Eur J Neurosci. 2007;25:3305-11 pubmed
  • 免疫印迹; 大鼠; 1:1000
Alzoubi K, Aleisa A, Alkadhi K. Molecular studies on the protective effect of nicotine in adult-onset hypothyroidism-induced impairment of long-term potentiation. Hippocampus. 2006;16:861-74 pubmed
  • 免疫印迹; 大鼠; 1:1000
Aleisa A, Alzoubi K, Gerges N, Alkadhi K. Chronic psychosocial stress-induced impairment of hippocampal LTP: possible role of BDNF. Neurobiol Dis. 2006;22:453-62 pubmed
  • 免疫印迹; 大鼠; 1:1000
Aleisa A, Alzoubi K, Alkadhi K. Nicotine prevents stress-induced enhancement of long-term depression in hippocampal area CA1: electrophysiological and molecular studies. J Neurosci Res. 2006;83:309-17 pubmed
  • 免疫印迹; 大鼠; 1:1000
Alzoubi K, Aleisa A, Alkadhi K. Impairment of long-term potentiation in the CA1, but not dentate gyrus, of the hippocampus in Obese Zucker rats: role of calcineurin and phosphorylated CaMKII. J Mol Neurosci. 2005;27:337-46 pubmed
  • 免疫细胞化学; 人类
Herrmann T, Morita C, Lee K, Kusner D. Calmodulin kinase II regulates the maturation and antigen presentation of human dendritic cells. J Leukoc Biol. 2005;78:1397-407 pubmed
  • 免疫细胞化学; 大鼠; 1:1000
  • 免疫印迹; 大鼠; 1:1000
Alzoubi K, Gerges N, Alkadhi K. Levothyroxin restores hypothyroidism-induced impairment of LTP of hippocampal CA1: electrophysiological and molecular studies. Exp Neurol. 2005;195:330-41 pubmed
  • 免疫印迹; 大鼠; 1:1000
Gerges N, Alzoubi K, Alkadhi K. Role of phosphorylated CaMKII and calcineurin in the differential effect of hypothyroidism on LTP of CA1 and dentate gyrus. Hippocampus. 2005;15:480-90 pubmed
Bertocchi I, Eltokhi A, Rozov A, Chi V, Jensen V, Bus T, et al. Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice. Commun Biol. 2021;4:59 pubmed 出版商
Miyagi H, Hiroshima M, Sako Y. Cell-to-cell diversification in ERBB-RAS-MAPK signal transduction that produces cell-type specific growth factor responses. Biosystems. 2021;199:104293 pubmed 出版商
La Montanara P, Hervera A, Baltussen L, Hutson T, Palmisano I, De Virgiliis F, et al. Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models. Sci Transl Med. 2020;12: pubmed 出版商
Kikuma K, Li X, Perry S, Li Q, Goel P, Chen C, et al. Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling. Nat Commun. 2019;10:2998 pubmed 出版商
Motloch L, Cacheux M, Ishikawa K, Xie C, Hu J, Aguero J, et al. Primary Effect of SERCA 2a Gene Transfer on Conduction Reserve in Chronic Myocardial Infarction. J Am Heart Assoc. 2018;7:e009598 pubmed 出版商
Li S, Xue J, Sun Z, Liu T, Zhang L, Wang L, et al. CaMKII Potentiates Store-Operated Ca2+ Entry Through Enhancing STIM1 Aggregation and Interaction with Orai1. Cell Physiol Biochem. 2018;46:1042-1054 pubmed 出版商
Li X, Goel P, Chen C, Angajala V, Chen X, Dickman D. Synapse-specific and compartmentalized expression of presynaptic homeostatic potentiation. elife. 2018;7: pubmed 出版商
Gobbo F, Marchetti L, Jacob A, Pinto B, Binini N, Pecoraro Bisogni F, et al. Activity-dependent expression of Channelrhodopsin at neuronal synapses. Nat Commun. 2017;8:1629 pubmed 出版商
Toischer K, Zhu W, Hünlich M, Mohamed B, Khadjeh S, Reuter S, et al. Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload. J Clin Invest. 2017;127:4285-4296 pubmed 出版商
Cerrone M, Montnach J, Lin X, Zhao Y, Zhang M, Agullo Pascual E, et al. Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm. Nat Commun. 2017;8:106 pubmed 出版商
Amar F, Sherman M, Rush T, LARSON M, Boyle G, Chang L, et al. The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation. Sci Signal. 2017;10: pubmed 出版商
Cao C, Rioult Pedotti M, Migani P, Yu C, Tiwari R, Parang K, et al. Impairment of TrkB-PSD-95 signaling in Angelman syndrome. PLoS Biol. 2013;11:e1001478 pubmed 出版商
Mishra S, Gray C, Miyamoto S, Bers D, Brown J. Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circ Res. 2011;109:1354-62 pubmed 出版商
Shifman J, Choi M, Mihalas S, Mayo S, Kennedy M. Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums. Proc Natl Acad Sci U S A. 2006;103:13968-73 pubmed
Wu X, Zhang T, Bossuyt J, Li X, McKinsey T, Dedman J, et al. Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest. 2006;116:675-82 pubmed
Xu G, Huang L. Ca2+/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors. Proc Natl Acad Sci U S A. 2004;101:11868-73 pubmed
Atkins C, Nozaki N, Shigeri Y, Soderling T. Cytoplasmic polyadenylation element binding protein-dependent protein synthesis is regulated by calcium/calmodulin-dependent protein kinase II. J Neurosci. 2004;24:5193-201 pubmed
Schmitt J, Wayman G, Nozaki N, Soderling T. Calcium activation of ERK mediated by calmodulin kinase I. J Biol Chem. 2004;279:24064-72 pubmed
Gerges N, Aleisa A, Schwarz L, Alkadhi K. Reduced basal CaMKII levels in hippocampal CA1 region: possible cause of stress-induced impairment of LTP in chronically stressed rats. Hippocampus. 2004;14:402-10 pubmed
Dong Y, Rosenberg H. Prolonged changes in Ca2+/calmodulin-dependent protein kinase II after a brief pentylenetetrazol seizure; potential role in kindling. Epilepsy Res. 2004;58:107-17 pubmed
Dong Y, Rosenberg H. Brief seizure activity alters Ca2+/calmodulin dependent protein kinase II dephosphorylation and subcellular distribution in rat brain for several hours. Neurosci Lett. 2004;357:95-8 pubmed
Wehrens X, Lehnart S, Reiken S, Marks A. Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res. 2004;94:e61-70 pubmed
Gerges N, Aleisa A, Schwarz L, Alkadhi K. Chronic psychosocial stress decreases calcineurin in the dentate gyrus: a possible mechanism for preservation of early ltp. Neuroscience. 2003;117:869-74 pubmed
Elgersma Y, Fedorov N, Ikonen S, Choi E, Elgersma M, Carvalho O, et al. Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron. 2002;36:493-505 pubmed
Fang L, Wu J, Lin Q, Willis W. Calcium-calmodulin-dependent protein kinase II contributes to spinal cord central sensitization. J Neurosci. 2002;22:4196-204 pubmed
Giovannini M, Blitzer R, Wong T, Asoma K, Tsokas P, Morrison J, et al. Mitogen-activated protein kinase regulates early phosphorylation and delayed expression of Ca2+/calmodulin-dependent protein kinase II in long-term potentiation. J Neurosci. 2001;21:7053-62 pubmed
Esteban L, Vicario Abejón C, Fernandez Salguero P, Fernandez Medarde A, Swaminathan N, Yienger K, et al. Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development. Mol Cell Biol. 2001;21:1444-52 pubmed
Steward O, Halpain S. Lamina-specific synaptic activation causes domain-specific alterations in dendritic immunostaining for MAP2 and CAM kinase II. J Neurosci. 1999;19:7834-45 pubmed
Ouyang Y, Rosenstein A, Kreiman G, Schuman E, Kennedy M. Tetanic stimulation leads to increased accumulation of Ca(2+)/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons. J Neurosci. 1999;19:7823-33 pubmed
Makhinson M, Chotiner J, Watson J, O Dell T. Adenylyl cyclase activation modulates activity-dependent changes in synaptic strength and Ca2+/calmodulin-dependent kinase II autophosphorylation. J Neurosci. 1999;19:2500-10 pubmed
Blitzer R, Connor J, Brown G, Wong T, Shenolikar S, Iyengar R, et al. Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. Science. 1998;280:1940-2 pubmed
Ouyang Y, Kantor D, Harris K, Schuman E, Kennedy M. Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus. J Neurosci. 1997;17:5416-27 pubmed
Kindler S, Kennedy M. Visualization of autophosphorylation of Ca2+/calmodulin-dependent protein kinase II in hippocampal slices. J Neurosci Methods. 1996;68:61-70 pubmed
Patton B, Molloy S, Kennedy M. Autophosphorylation of type II CaM kinase in hippocampal neurons: localization of phospho- and dephosphokinase with complementary phosphorylation site-specific antibodies. Mol Biol Cell. 1993;4:159-72 pubmed
图像
图像 1 :
赛默飞世尔 MA1-047 图像 1
Western blot detection of unphosphorylated and phosphorylated rat brain homogenate (left and right lanes respectively) using MA1-047 and MA1-048 antibodies.
图像 2 :
赛默飞世尔 MA1-047 图像 2
Immunofluorescent analysis of Phospho-CaM Kinase II pThr286 using Anti-Phospho-CaM Kinase II pThr286 Monoclonal Antibody (22B1) (Product# MA1-047) shows staining in Hela Cells. Phospho-CaM Kinase II pThr286 staining (green) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing Phospho-CaM Kinase II pThr286 (Product# MA1-047) at a dilution of 1:50 over night at 4 ?C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody (Product# 35503, Goat Anti-Mouse). Images were taken at 60X magnification.
产品信息
产品类型 :
抗体
产品名称 :
磷酸化CaMKII甲(Thr286)单克隆抗体(22B1)
目录# :
MA1-047
规格 :
100微升
价格 :
美国412.00
克隆性 :
单克隆
纯度 :
蛋白质G
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
ELISA: Assay-dependent, Flow Cytometry: 1 µg / 10^6 cells, Immunocytochemistry: 1:100, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:2,000
物种 :
人类, 小鼠, 大鼠
克隆 :
22B1
抗体亚型 :
IgG1
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+/calmodulin (CaM) binding and autophosphorylation and has been implicated in regulation of the cell cycle and transcription. It is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner.
免疫原 :
Synthetic peptide corresponding to residues M(281) H R Q E T(p) V D C L K K F N(294) of rat CaM Kinase II protein.
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Flow Cytometry: 1 µg / 10^6 cells, Immunocytochemistry: 1:100, Immunohistochemistry: Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:2,000
别名 :
alpha CaM kinase II; alpha-CaMKII; Ca2+/calmodulin-dependent protein kinase II; Ca2+/calmodulin-dependent protein kinase II alpha; Calci; calcium/calmodulin dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase II alpha subunit; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II alpha subunit; caM kinase II subunit alpha; CaMK II; CAMK2; Camk2a; CAMKA; CaMKII; CaMK-II alpha subunit; caMK-II subunit alpha; CaMKIINalpha; CaM-kinase II alpha chain; EC 2.7.11.17; KIAA0968; mKIAA0968; OTTHUMP00000165787; OTTHUMP00000165788; Phospho-CaMKI; PK2CDD; PKCCD; R74975
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国