产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
Bcl-2 Monoclonal Antibody (10C4)
目录 :
MA1-12246
规格 :
100微克
价格 :
美国446.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
10C4
反应物种 :
小鼠, 大鼠
应用 :
免疫印迹, 免疫细胞化学, 流式细胞仪, 免疫组化-冰冻切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 19
出版应用/物种/样本/稀释参考文献
  • 流式细胞仪; 小鼠; 图 6d
Visekruna A, Hartmann S, Sillke Y, Glauben R, Fischer F, Raifer H, et al. Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells. J Clin Invest. 2019;129:1972-1983 pubmed 出版商
  • 流式细胞仪; 小鼠; 1:200; 图 5e
Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, et al. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun. 2018;9:2812 pubmed 出版商
  • 流式细胞仪; 小鼠
Saha A, O Connor R, Thangavelu G, Lovitch S, Dandamudi D, Wilson C, et al. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest. 2016;126:2642-60 pubmed 出版商
  • 免疫印迹; 大鼠
Xu H, Zhu G, Tian Y. Protective effects of trimetazidine on bone marrow mesenchymal stem cells viability in an ex vivo model of hypoxia and in vivo model of locally myocardial ischemia. J Huazhong Univ Sci Technolog Med Sci. 2012;32:36-41 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Baquedano E, García Cáceres C, Diz Chaves Y, Lagunas N, Calmarza Font I, Azcoitia I, et al. Prenatal stress induces long-term effects in cell turnover in the hippocampus-hypothalamus-pituitary axis in adult male rats. PLoS ONE. 2011;6:e27549 pubmed 出版商
  • 免疫印迹; 小鼠
Hirai H, Verma M, Watanabe S, Tastad C, Asakura Y, Asakura A. MyoD regulates apoptosis of myoblasts through microRNA-mediated down-regulation of Pax3. J Cell Biol. 2010;191:347-65 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Delgado Rubín A, Chowen J, Argente J, Frago L. Growth hormone-releasing peptide 6 protection of hypothalamic neurons from glutamate excitotoxicity is caspase independent and not mediated by insulin-like growth factor I. Eur J Neurosci. 2009;29:2115-24 pubmed 出版商
  • 免疫印迹; 大鼠; 1:200
Nahas Z, Jiang Y, Zeidan Y, Bielawska A, Szulc Z, DeVane L, et al. Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats. Behav Brain Res. 2009;197:41-4 pubmed 出版商
  • 免疫印迹; 小鼠
Götschel F, Kern C, Lang S, Sparna T, Markmann C, Schwager J, et al. Inhibition of GSK3 differentially modulates NF-kappaB, CREB, AP-1 and beta-catenin signaling in hepatocytes, but fails to promote TNF-alpha-induced apoptosis. Exp Cell Res. 2008;314:1351-66 pubmed 出版商
  • 免疫印迹; 小鼠
Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Schulze Osthoff K, et al. TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest. Oncogene. 2008;27:116-25 pubmed
  • 免疫印迹; 大鼠; 1:1000
Delgado Rubín de Célix A, Chowen J, Argente J, Frago L. Growth hormone releasing peptide-6 acts as a survival factor in glutamate-induced excitotoxicity. J Neurochem. 2006;99:839-49 pubmed
  • 免疫细胞化学; 大鼠; 1:100
Chai Y, Niu L, Sun X, Ding J, Hu G. Iptakalim protects PC12 cell against H2O2-induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel. Biochem Biophys Res Commun. 2006;350:307-14 pubmed
  • 免疫印迹; 小鼠
López Diazguerrero N, López Araiza H, Conde Perezprina J, Bucio L, Cárdenas Aguayo M, Ventura J, et al. Bcl-2 protects against oxidative stress while inducing premature senescence. Free Radic Biol Med. 2006;40:1161-9 pubmed
  • 免疫组化-冰冻切片; 大鼠; 2.5 ug/ml; 图 7
Yamanaka T, Helgeland L, Farstad I, Fukushima H, Midtvedt T, Brandtzaeg P. Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches. J Immunol. 2003;170:816-22 pubmed
  • 免疫细胞化学; 大鼠; 1:100; 图 1
  • 免疫印迹; 大鼠; 1:1000; 图 1
Kaufmann T, Schlipf S, Sanz J, Neubert K, Stein R, Borner C. Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane. J Cell Biol. 2003;160:53-64 pubmed
Tan L, Qu W, Wu D, Liu M, Ai Q, Hu H, et al. The interferon regulatory factor 6 promotes cisplatin sensitivity in colorectal cancer. Bioengineered. 2022;13:10504-10517 pubmed 出版商
Niogret C, Miah S, Rota G, Fonta N, Wang H, Held W, et al. Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells. Nat Commun. 2019;10:1444 pubmed 出版商
Mayorga M, Bahi N, Ballester M, Comella J, Sanchis D. Bcl-2 is a key factor for cardiac fibroblast resistance to programmed cell death. J Biol Chem. 2004;279:34882-9 pubmed
Putcha G, Harris C, Moulder K, Easton R, Thompson C, Johnson E. Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J Cell Biol. 2002;157:441-53 pubmed
产品信息
产品类型 :
抗体
产品名称 :
Bcl-2 Monoclonal Antibody (10C4)
目录# :
MA1-12246
规格 :
100微克
价格 :
美国446.00
克隆性 :
单克隆
纯度 :
蛋白质A/G
宿主 :
小鼠
反应物种 :
小鼠, 大鼠
应用 :
Western Blot: 1-10 µg/mL
物种 :
小鼠, 大鼠
克隆 :
10C4
抗体亚型 :
IgG1
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
免疫原 :
Synthetic peptide corresponding to residues 61-76 of mouse bcl-2.
格式 :
液体
应用w/稀释 :
Western Blot: 1-10 µg/mL
别名 :
apoptosis regulator Bcl-2; AW986256; B cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl 2; BCL2; bcl-2; BCL2 apoptosis regulator; Bcl-2 protein; BCL2, apoptosis regulator; Bcl2-like protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; OTTHUMP00000163680; PPP1R50; protein phosphatase 1, regulatory subunit 50
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国