产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
雄激素受体单克隆抗体(AN1-15)
目录 :
MA1-150
规格 :
50微克
价格 :
美国430.00
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
AN1-15
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 22
出版应用/物种/样本/稀释 | 参考文献 |
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Shakil T, Hoque A, Husain M, Belsham D. Differential regulation of gonadotropin-releasing hormone secretion and gene expression by androgen: membrane versus nuclear receptor activation. Mol Endocrinol. 2002;16:2592-602 pubmed
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Yamamoto A, Hashimoto Y, Kohri K, Ogata E, Kato S, Ikeda K, et al. Cyclin E as a coactivator of the androgen receptor. J Cell Biol. 2000;150:873-80 pubmed
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Zhang M, Magit D, Sager R. Expression of maspin in prostate cells is regulated by a positive ets element and a negative hormonal responsive element site recognized by androgen receptor. Proc Natl Acad Sci U S A. 1997;94:5673-8 pubmed
| |
Nakada S, di Sant Agnese P, Moynes R, Hiipakka R, Liao S, Cockett A, et al. The androgen receptor status of neuroendocrine cells in human benign and malignant prostatic tissue. Cancer Res. 1993;53:1967-70 pubmed
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Morvillo V, Luthy I, Bravo A, Capurro M, Donaldson M, Quintans C, et al. Atypical androgen receptor in the human melanoma cell line IIB-MEL-J. Pigment Cell Res. 1995;8:135-41 pubmed
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Luke M, Coffey D. Human androgen receptor binding to the androgen response element of prostate specific antigen. J Androl. 1994;15:41-51 pubmed
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Puy L, MacLusky N, Becker L, Karsan N, Trachtenberg J, Brown T. Immunocytochemical detection of androgen receptor in human temporal cortex characterization and application of polyclonal androgen receptor antibodies in frozen and paraffin-embedded tissues. J Steroid Biochem Mol Biol. 1995;55:197-209 pubmed
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Chang C, Whelan C, Popovich T, Kokontis J, Liao S. Fusion proteins containing androgen receptor sequences and their use in the production of poly- and monoclonal anti-androgen receptor antibodies. Endocrinology. 1989;125:1097-9 pubmed
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Chang C, Chodak G, Sarac E, Takeda H, Liao S. Prostate androgen receptor: immunohistological localization and mRNA characterization. J Steroid Biochem. 1989;34:311-3 pubmed
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West N, Chang C, Liao S, Brenner R. Localization and regulation of estrogen, progestin and androgen receptors in the seminal vesicle of the rhesus monkey. J Steroid Biochem Mol Biol. 1990;37:11-21 pubmed
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Takeda H, Chodak G, Mutchnik S, Nakamoto T, Chang C. Immunohistochemical localization of androgen receptors with mono- and polyclonal antibodies to androgen receptor. J Endocrinol. 1990;126:17-25 pubmed
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Roselli C, West N, Brenner R. Androgen receptor and 5 alpha-reductase activity in the ductuli efferentes and epididymis of adult rhesus macaques. Biol Reprod. 1991;44:739-45 pubmed
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Takeda H, Nakamoto T, Kokontis J, Chodak G, Chang C. Autoregulation of androgen receptor expression in rodent prostate: immunohistochemical and in situ hybridization analysis. Biochem Biophys Res Commun. 1991;177:488-96 pubmed
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Cutolo M, Accardo S, Villaggio B, Clerico P, Indiveri F, Carruba G, et al. Evidence for the presence of androgen receptors in the synovial tissue of rheumatoid arthritis patients and healthy controls. Arthritis Rheum. 1992;35:1007-15 pubmed
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Brolin J, Skoog L, Ekman P. Immunohistochemistry and biochemistry in detection of androgen, progesterone, and estrogen receptors in benign and malignant human prostatic tissue. Prostate. 1992;20:281-95 pubmed
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图像
图像 1 :
产品信息
产品类型 :
抗体
产品名称 :
雄激素受体单克隆抗体(AN1-15)
目录# :
MA1-150
规格 :
50微克
价格 :
美国430.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
大鼠
反应物种 :
Human, Mouse, Non-human primate, Rat
应用 :
Gel Shift: Assay-dependent, Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Frozen): 2-4 µg/mL, Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1:50-1:500
物种 :
Human, Mouse, Non-human primate, Rat
克隆 :
AN1-15
抗体亚型 :
IgG
储存 :
-20° C, 避免反复冷冻/解冻
描述 :
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).
免疫原 :
A fusion protein corresponding to residues 331-572 of human androgen receptor.
格式 :
冻干
应用w/稀释 :
Gel Shift: Assay-dependent, Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Frozen): 2-4 µg/mL, Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1:50-1:500
别名 :
AIS; Andr; androgen nuclear receptor variant 2; androgen receptor; androgen receptor (Testicular feminization), same as Tfm; androgen receptor splice variant 4b; Ar; AR8; AR-A; AW320017; DHTR; dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; RP11-383C12.1; SBMA; SMAX1; TFM; Variant AR45
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公司信息
赛默飞世尔