产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
BCR-ABL单克隆抗体(7C6)
目录 :
MA1-153
规格 :
100微克
价格 :
美国470.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
7C6
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 1
参考文献
Jeanpierre S, Arizkane K, Thongjuea S, Grockowiak E, Geistlich K, Barral L, et al. The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remission. Haematologica. 2021;106:111-122 pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
BCR-ABL单克隆抗体(7C6)
目录# :
MA1-153
规格 :
100微克
价格 :
美国470.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类, 小鼠
应用 :
Immunocytochemistry: 1:50-1:100, Immunohistochemistry (Paraffin): 1:50-1:500, Immunoprecipitation: 5 µg, Western Blot: 1:500-1:1,000
物种 :
人类, 小鼠
克隆 :
7C6
抗体亚型 :
IgG2a
储存 :
-20°C
描述 :
A reciprocal translocation between chromosomes 22 and 9 produces the BCR-ABL fusion oncoprotein, which is found in patients with chronic myelogenous leukemia (CML). Although there are various versions, p210 is the most commonly found BCR-ABL form. The fusion to BCR, results in deregulated/constitutively active tyrosine kinase activity of BCR-ABL which is sufficient of oncogenic transformation of myeloid cells. Inhibition of BCR-ABL oncogenic activity by the ABL-kinase inhibitor STI-571 (also known as gleevec, imatinib) became the first and best example for successful targeted therapy of cancer, and specifically CML. In recent years, several mutations (such as the T351I mutation) were found in CML patients that resulted in STI-571 resistance and the need for additional drug development.
免疫原 :
Bcr686 thyroglobulin conjugate corresponding to human BCR sequence 686-696 (SSINEEITPRRQS)
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:50-1:100, Immunohistochemistry (Paraffin): 1:50-1:500, Immunoprecipitation: 5 µg, Western Blot: 1:500-1:1,000
别名 :
5133400C09Rik; AI561783; AI853148; ALL; BCR; BCR, RhoGEF and GTPase activating protein; BCR/FGFR1 chimera protein; BCR1; breakpoint cluster region; breakpoint cluster region homolog; breakpoint cluster region protein; CML; D22S11; D22S662; FGFR1/BCR chimera protein; Kiaa3017; mKIAA3017; PHL; Renal carcinoma antigen NY-REN-26
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国