产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
p53单克隆抗体(BP53-12)
目录 :
MA1-19055
规格 :
100微克
价格 :
美国496.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
BP53-12
反应物种 :
人类, 小鼠, 大鼠, 猕猴
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 128
| 出版应用/物种/样本/稀释 | 参考文献 |
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| Basak K, Doguc D, Aylak F, Karadayi N, Gultekin F. Effects of maternally exposed food coloring additives on laryngeal histology in rats. J Environ Pathol Toxicol Oncol. 2014;33:123-30 pubmed
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| Zhao Z, Lin L, Liang A, Li H, Zhu Y. UNC5H4-induced apoptosis in non-small cell lung cancer is not dependent on p53 status only. Oncol Lett. 2013;6:1363-1369 pubmed
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| Bakry O, Hammam M, Abdel Wahed M. Vitiligo: is it grace or curse?. Acta Dermatovenerol Croat. 2013;21:71-9 pubmed
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| Zhang J, Wang Y, Yin Q, Zhang W, Zhang T, Niu Y. An associated classification of triple negative breast cancer: the risk of relapse and the response to chemotherapy. Int J Clin Exp Pathol. 2013;6:1380-91 pubmed
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| Erdem H, Oktay M, Yildirim U, Uzunlar A, Kayikci M. Expression of AEG-1 and p53 and their clinicopathological significance in malignant lesions of renal cell carcinomas: a microarray study. Pol J Pathol. 2013;64:28-32 pubmed
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| Oka Y, Yamauchi M, Suzuki M, Yamashita S, Suzuki K. Persistence and dynamics of DNA damage signal amplification determined by microcolony formation and live-cell imaging. J Radiat Res. 2011;52:766-74 pubmed
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| Lee J, Lee K, Park J, Bae S, Lee K, Lee J, et al. Predictive factors associated with malignancy of intraductal papillary mucinous pancreatic neoplasms. World J Gastroenterol. 2010;16:5353-8 pubmed
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| Thant A, Wu Y, Lee J, Mishra D, Garcia H, Koeffler H, et al. Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells. Anticancer Res. 2008;28:3579-92 pubmed
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| Cho E, Choi Y, Han J, Kim K, Oh Y. Expression and amplification of Her2, EGFR and cyclin D1 in breast cancer: immunohistochemistry and chromogenic in situ hybridization. Pathol Int. 2008;58:17-25 pubmed
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| Barzilai A, Lyakhovitsky A, Trau H, Fogel M, Huszar M. Expression of p53 in the evolution of squamous cell carcinoma: correlation with the histology of the lesion. J Am Acad Dermatol. 2007;57:669-76 pubmed
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| Giordano G, D Adda T, Gnetti L, Merisio C, Raboni S. Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature. Int J Gynecol Pathol. 2007;26:298-304 pubmed
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| Ray S, Chatterjee A. Influence of glutathione on the induction of chromosome aberrations, delay in cell cycle kinetics and cell cycle regulator proteins in irradiated mouse bone marrow cells. Int J Radiat Biol. 2007;83:347-54 pubmed
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| Giordano G, D Adda T, Gnetti L, Merisio C, Gabrielli M, Melpignano M. Villoglandular adenocarcinoma of the cervix: two new cases with morphological and molecular study. Int J Gynecol Pathol. 2007;26:199-204 pubmed
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| Rossner P, Binkova B, Milcova A, Solansky I, Zidzik J, Lyubomirova K, et al. Air pollution by carcinogenic PAHs and plasma levels of p53 and p21(WAF1) proteins. Mutat Res. 2007;620:34-40 pubmed
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| Schumacher G, Scheunert S, Rueggeberg A, Bachem M, Nussler A, Spinelli A, et al. A very low toxic agent induces apoptosis and reduces growth of human hepatocellular carcinoma cells. J Gastroenterol Hepatol. 2006;21:1207-12 pubmed
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| Seidman J, Kumar D, Cosin J, Winter W, Cargill C, Boice C. Carcinomas of the female genital tract occurring after pelvic irradiation: a report of 15 cases. Int J Gynecol Pathol. 2006;25:293-7 pubmed
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| Cho E, Choi Y, Chae S, Sohn J, Ahn G. Relationship between p53-associated proteins and estrogen receptor status in ovarian serous neoplasms. Int J Gynecol Cancer. 2006;16:1000-6 pubmed
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| Kim K, Park E, Seo Y, Cho H, Kim C, Kim K, et al. Immunohistochemical study of cyclooxygenase-2 and p53 expression in skin tumors. J Dermatol. 2006;33:319-25 pubmed
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| Pizzimenti S, Briatore F, Laurora S, Toaldo C, Maggio M, De Grandi M, et al. 4-Hydroxynonenal inhibits telomerase activity and hTERT expression in human leukemic cell lines. Free Radic Biol Med. 2006;40:1578-91 pubmed
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| Lee M, Suh C, Li Z. Clinicopathological significance of maspin expression in breast cancer. J Korean Med Sci. 2006;21:309-14 pubmed
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| Suzuki M, Suzuki K, Kodama S, Watanabe M. Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest. Biochem Biophys Res Commun. 2006;340:145-50 pubmed
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| Yakirevich E, Sabo E, Naroditsky I, Sova Y, Lavie O, Resnick M. Multidrug resistance-related phenotype and apoptosis-related protein expression in ovarian serous carcinomas. Gynecol Oncol. 2006;100:152-9 pubmed
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| Osada M, Nagakawa Y, Park H, Yamashita K, Wu G, Kim M, et al. p63-specific activation of the BPAG-1e promoter. J Invest Dermatol. 2005;125:52-60 pubmed
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| Yamauchi M, Suzuki K, Kodama S, Watanabe M. Abnormal stability of wild-type p53 protein in a human lung carcinoma cell line. Biochem Biophys Res Commun. 2005;330:483-8 pubmed
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| Gumus E, Erdamar S, Demirel G, Horasanli K, Kendirci M, Miroglu C. Association of positive serum anti-p53 antibodies with poor prognosis in bladder cancer patients. Int J Urol. 2004;11:1070-7 pubmed
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| Torkin R, Lavoie J, Kaplan D, Yeger H. Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma. Mol Cancer Ther. 2005;4:1-11 pubmed
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| Laurora S, Tamagno E, Briatore F, Bardini P, Pizzimenti S, Toaldo C, et al. 4-Hydroxynonenal modulation of p53 family gene expression in the SK-N-BE neuroblastoma cell line. Free Radic Biol Med. 2005;38:215-25 pubmed
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| Bar Sela G, Ben Arush M, Sabo E, Kuten A, Minkov I, Ben Izhak O. Pediatric nasopharyngeal carcinoma: better prognosis and increased c-Kit expression as compared to adults. Pediatr Blood Cancer. 2005;45:291-7 pubmed
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| Park H, Min S, Cho H, Kim K, Shin H, Park Y. Expression profiles of p63, p53, survivin, and hTERT in skin tumors. J Cutan Pathol. 2004;31:544-9 pubmed
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| Song S, Park S, Kim S, Suh Y. Oncocytic adrenocortical carcinomas: a pathological and immunohistochemical study of four cases in comparison with conventional adrenocortical carcinomas. Pathol Int. 2004;54:603-10 pubmed
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| Kim N, Wang K, Bang J, Choe G, Park Y, Kim S, et al. Glioblastomatous transformation of ganglioglioma: case report with reference to molecular genetic and flow cytometric analysis. Pathol Int. 2003;53:874-82 pubmed
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| Mathur M, Das S, Samuels H. PSF-TFE3 oncoprotein in papillary renal cell carcinoma inactivates TFE3 and p53 through cytoplasmic sequestration. Oncogene. 2003;22:5031-44 pubmed
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| Li C, Hirokawa M, Qian Z, Fujii Y, Ino H, Wakatsuki S, et al. Morules with optically clear nuclei in ovarian borderline endometrioid tumor. APMIS. 2002;110:783-8 pubmed
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| Lee S, Park C, Sung C, Choi J, Oh Y, Cho J, et al. Correlation of mutation and immunohistochemistry of p53 in hepatocellular carcinomas in Korean people. J Korean Med Sci. 2002;17:801-5 pubmed
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| Rheinwald J, Hahn W, Ramsey M, Wu J, Guo Z, Tsao H, et al. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol Cell Biol. 2002;22:5157-72 pubmed
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| Kang Y, Kim K, Yu Y, Lim S, Kim Y, Park K. The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer. J Korean Med Sci. 2001;16:417-23 pubmed
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| Park Y, Park H, Chi S, Ushigome S, Unni K. Overexpression of p53 and absent genetic mutation in clear cell chondrosarcoma. Int J Oncol. 2001;19:353-7 pubmed
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| Chowers I, Pe er J, Zamir E, Livni N, Ilsar M, Frucht Pery J. Proliferative activity and p53 expression in primary and recurrent pterygia. Ophthalmology. 2001;108:985-8 pubmed
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| Dickson M, Hahn W, Ino Y, Ronfard V, Wu J, Weinberg R, et al. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol. 2000;20:1436-47 pubmed
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| Tashima S, Shimada S, Yamaguchi K, Tsuruta J, Ogawa M. Expression of brain-type glycogen phosphorylase is a potentially novel early biomarker in the carcinogenesis of human colorectal carcinomas. Am J Gastroenterol. 2000;95:255-63 pubmed
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| Shiga H, Heath E, Rasmussen A, Trock B, Johnston P, Forastiere A, et al. Prognostic value of p53, glutathione S-transferase pi, and thymidylate synthase for neoadjuvant cisplatin-based chemotherapy in head and neck cancer. Clin Cancer Res. 1999;5:4097-104 pubmed
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| Bradford C, Wolf G, Carey T, Zhu S, Beals T, Truelson J, et al. Predictive markers for response to chemotherapy, organ preservation, and survival in patients with advanced laryngeal carcinoma. Otolaryngol Head Neck Surg. 1999;121:534-8 pubmed
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| Hodak E, Hammel I, Feinmesser M, Zelinger A, Maron L, Sulkes J, et al. Differential expression of p53 and Ki-67 proteins in classic and iatrogenic Kaposi's sarcoma. Am J Dermatopathol. 1999;21:138-45 pubmed
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| Nikol S, Huehns T, Weir L, Wight T, Hofling B. Restenosis in human vein bypass grafts. Atherosclerosis. 1998;139:31-9 pubmed
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| Mateo M, Sanchez Beato M, Martinez J, Orfao A, Orradre J, Piris M. p53, Rb and bcl-2 expression during the cell cycle: a study in phytohaemagglutinin stimulated lymphocytes and microwave irradiated lymphoid tissue sections. J Clin Pathol. 1995;48:151-9 pubmed
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| Livni N, Eid A, Ilan Y, Rivkind A, Rosenmann E, Blendis L, et al. p53 expression in patients with cirrhosis with and without hepatocellular carcinoma. Cancer. 1995;75:2420-6 pubmed
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Li Z, Day C, Yang J, Tsai W, Lozano G, Shih H, et al. Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53. Cancer Res. 2004;64:9080-5 pubmed
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Milne A, Carvalho R, van Rees B, van Lanschot J, Offerhaus G, Weterman M. Do collision tumors of the gastroesophageal junction exist? A molecular analysis. Am J Surg Pathol. 2004;28:1492-8 pubmed
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Fomenkov A, Zangen R, Huang Y, Osada M, Guo Z, Fomenkov T, et al. RACK1 and stratifin target DeltaNp63alpha for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage. Cell Cycle. 2004;3:1285-95 pubmed
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Yamauchi M, Suzuki K, Kodama S, Watanabe M. Stabilization of alanine substituted p53 protein at Ser15, Thr18, and Ser20 in response to ionizing radiation. Biochem Biophys Res Commun. 2004;323:906-11 pubmed
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Tokumaru Y, Yamashita K, Osada M, Nomoto S, Sun D, Xiao Y, et al. Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing. Cancer Res. 2004;64:5982-7 pubmed
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Tulunay O, Gogus C, Baltaci S, Bulut S. Clear cell adenocarcinoma of the tunica vaginalis of the testis with an adjacent uterus-like tissue. Pathol Int. 2004;54:641-7 pubmed
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller A, Caruso A, et al. Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. J Neurosci. 2004;24:6021-7 pubmed
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Tabs S, Avci O. Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity. Eur J Dermatol. 2004;14:96-102 pubmed
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Roberts K, Bhatia K, Stanton P, Lord R. Proteomic analysis of selected prognostic factors of breast cancer. Proteomics. 2004;4:784-92 pubmed
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Deveci M, Deveci G. Altered distribution of metaplastic Paneth, gastrin and pancreatic acinar cells in atrophic gastritic mucosa with endocrine cell lesions. Tohoku J Exp Med. 2004;202:13-22 pubmed
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Alami J, Williams B, Yeger H. Derivation and characterization of a Wilms' tumour cell line, WiT 49. Int J Cancer. 2003;107:365-74 pubmed
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Hamada N, Kodama S, Suzuki K, Watanabe M. Gap junctional intercellular communication and cellular response to heat stress. Carcinogenesis. 2003;24:1723-8 pubmed
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Mascaux C, Martin B, Verdebout J, Meert A, Ninane V, Sculier J. Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53. Eur Respir J. 2003;21:753-8 pubmed
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Campas C, Dalmau M, Montaner B, Barragan M, Bellosillo B, Colomer D, et al. Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia. Leukemia. 2003;17:746-50 pubmed
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Campas C, Lopez J, Santidrian A, Barragan M, Bellosillo B, Colomer D, et al. Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. Blood. 2003;101:3674-80 pubmed
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DiRenzo J, Signoretti S, Nakamura N, Rivera Gonzalez R, Sellers W, Loda M, et al. Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line. Cancer Res. 2002;62:89-98 pubmed
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Suzuki K, Kodama S, Watanabe M. Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation. J Biol Chem. 1999;274:25571-5 pubmed
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Ghosh J, Suzuki K, Kodama S, Watanabe M. Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation. J Radiat Res. 1999;40:23-37 pubmed
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图像
图像 1 :
产品信息
产品类型 :
抗体
产品名称 :
p53单克隆抗体(BP53-12)
目录# :
MA1-19055
规格 :
100微克
价格 :
美国496.00
克隆性 :
单克隆
纯度 :
sequential chromatography
宿主 :
小鼠
反应物种 :
Human, Non-human primate
应用 :
ELISA: Assay-dependent, Flow Cytometry: 1-4 µg/mL, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 5-10 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1-2 µg/mL
物种 :
Human, Non-human primate
克隆 :
BP53-12
抗体亚型 :
IgG2a
储存 :
4° C, 不冻结
描述 :
The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. p53 has been characterized to play a role in blocking the proliferative action of damaged cells and act as an anticancer agent. Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors. In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory. p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome.
免疫原 :
Bacterially expressed full-length wild-type p53
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Flow Cytometry: 1-4 µg/mL, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 5-10 µg/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1-2 µg/mL
别名 :
Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
更多信息或购买 :
公司信息
赛默飞世尔