产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
p53单克隆抗体(BP53-12)
目录 :
MA1-19055
规格 :
100微克
价格 :
美国425.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
BP53-12
反应物种 :
人类, 小鼠, 大鼠, 猕猴
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 127
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 人类; 1:500; 图 2n
Ronellenfitsch M, Oh J, Satomi K, Sumi K, Harter P, Steinbach J, et al. CASP9 germline mutation in a family with multiple brain tumors. Brain Pathol. 2018;28:94-102 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Strickland S, Vande Pol S. The Human Papillomavirus 16 E7 Oncoprotein Attenuates AKT Signaling To Promote Internal Ribosome Entry Site-Dependent Translation and Expression of c-MYC. J Virol. 2016;90:5611-5621 pubmed 出版商
  • 免疫组化; 人类; 1:4000; 表 1
Lee S, Bae S, Lee J, Lee H, Yi H, Kil W, et al. Distinguishing Low-Risk Luminal A Breast Cancer Subtypes with Ki-67 and p53 Is More Predictive of Long-Term Survival. PLoS ONE. 2015;10:e0124658 pubmed 出版商
  • 免疫组化; 大鼠; 1:100; 图 1, 2, 3
Basak K, Doguc D, Aylak F, Karadayi N, Gultekin F. Effects of maternally exposed food coloring additives on laryngeal histology in rats. J Environ Pathol Toxicol Oncol. 2014;33:123-30 pubmed
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Cubillos Rojas M, Amair Pinedo F, Peiró Jordán R, Bartrons R, Ventura F, Rosa J. The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization. J Biol Chem. 2014;289:14782-95 pubmed 出版商
  • 免疫组化; 人类
Akay O, Aras B, Isiksoy S, Toprak C, Mutlu F, Artan S, et al. BCL2, BCL6, IGH, TP53, and MYC protein expression and gene rearrangements as prognostic markers in diffuse large B-cell lymphoma: a study of 44 Turkish patients. Cancer Genet. 2014;207:87-93 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Stelloo E, Nout R, Naves L, Ter Haar N, Creutzberg C, Smit V, et al. High concordance of molecular tumor alterations between pre-operative curettage and hysterectomy specimens in patients with endometrial carcinoma. Gynecol Oncol. 2014;133:197-204 pubmed 出版商
  • 免疫组化; 人类; 1:250
Mingels M, van Ham M, de Kievit I, Snijders M, van Tilborg A, Bulten J, et al. Müllerian precursor lesions in serous ovarian cancer patients: using the SEE-Fim and SEE-End protocol. Mod Pathol. 2014;27:1002-13 pubmed 出版商
  • 免疫组化; 人类; 1:200
  • 免疫印迹; 人类; 1:200
Zhao Z, Lin L, Liang A, Li H, Zhu Y. UNC5H4-induced apoptosis in non-small cell lung cancer is not dependent on p53 status only. Oncol Lett. 2013;6:1363-1369 pubmed
  • 免疫组化; 人类; 1:500
Baumgarten P, Harter P, Tonjes M, Capper D, Blank A, Sahm F, et al. Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity. Neuropathol Appl Neurobiol. 2014;40:205-16 pubmed 出版商
  • 免疫组化; 人类; 1:50
Bakry O, Hammam M, Abdel Wahed M. Vitiligo: is it grace or curse?. Acta Dermatovenerol Croat. 2013;21:71-9 pubmed
  • 免疫组化-石蜡切片; 人类; 1:200; 图 1
Jeong Y, Jeong H, Lee S, Bong J, Park S, Oh H. Promoter methylation status of the FHIT gene and Fhit expression: association with HER2/neu status in breast cancer patients. Oncol Rep. 2013;30:2270-8 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:500; 表 1
Maschio L, Madallozo B, Capellasso B, Jardim B, Moschetta M, Jampietro J, et al. Immunohistochemical investigation of the angiogenic proteins VEGF, HIF-1? and CD34 in invasive ductal carcinoma of the breast. Acta Histochem. 2014;116:148-57 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 2
Zhang J, Wang Y, Yin Q, Zhang W, Zhang T, Niu Y. An associated classification of triple negative breast cancer: the risk of relapse and the response to chemotherapy. Int J Clin Exp Pathol. 2013;6:1380-91 pubmed
  • 免疫组化; 人类; 1:1000
Sarasqueta A, Forte G, Corver W, de Miranda N, Ruano D, van Eijk R, et al. Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer. BMC Cancer. 2013;13:277 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Lee S, Kim H, Kim W, Han H, Lim S, Kim W, et al. Genetic alteration and immunohistochemical staining patterns of ovarian high-grade serous adenocarcinoma with special emphasis on p53 immnnostaining pattern. Pathol Int. 2013;63:252-9 pubmed 出版商
  • 免疫组化; 人类
Bosse T, Ter Haar N, Seeber L, v Diest P, Hes F, Vasen H, et al. Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations, TP53 and microsatellite instability in endometrial cancer. Mod Pathol. 2013;26:1525-35 pubmed 出版商
  • 免疫组化-石蜡切片; 人类
Erdem H, Oktay M, Yildirim U, Uzunlar A, Kayikci M. Expression of AEG-1 and p53 and their clinicopathological significance in malignant lesions of renal cell carcinomas: a microarray study. Pol J Pathol. 2013;64:28-32 pubmed
  • 免疫组化; 人类
Malhotra P, Anwar M, Nanda N, Kochhar R, Wig J, Vaiphei K, et al. Alterations in K-ras, APC and p53-multiple genetic pathway in colorectal cancer among Indians. Tumour Biol. 2013;34:1901-11 pubmed 出版商
  • 免疫组化; 人类
Gurzu S, Szentirmay Z, Toth E, Bara T, Jung I. Serrated pathway adenocarcinomas: molecular and immunohistochemical insights into their recognition. PLoS ONE. 2013;8:e57699 pubmed 出版商
  • 免疫组化; 人类; 1:200
  • 免疫印迹; 人类; 1:250; 图 2
Kasimanickam V, Kasimanickam R, Rogers H. Immunolocalization of retinoic acid receptor-alpha, -beta, and -gamma, in bovine and canine sperm. Theriogenology. 2013;79:1010-8 pubmed 出版商
  • 免疫组化; 人类; 1:100
Rosati A, Poliani P, Todeschini A, Cominelli M, Medicina D, Cenzato M, et al. Glutamine synthetase expression as a valuable marker of epilepsy and longer survival in newly diagnosed glioblastoma multiforme. Neuro Oncol. 2013;15:618-25 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500
  • 免疫组化; 人类; 1:500
Harter P, Dützmann S, Drott U, Zachskorn C, Hattingen E, Capper D, et al. Anti-tissue factor (TF9-10H10) treatment reduces tumor cell invasiveness in a novel migratory glioma model. Neuropathology. 2013;33:515-25 pubmed 出版商
  • 免疫印迹; 人类
Mosoyan G, Nagi C, Marukian S, Teixeira A, Simonian A, Resnick Silverman L, et al. Multiple breast cancer cell-lines derived from a single tumor differ in their molecular characteristics and tumorigenic potential. PLoS ONE. 2013;8:e55145 pubmed 出版商
  • 免疫细胞化学; 人类; 图 4
Olszewska E, Rutkowska J, Minovi A, Sieskiewicz A, Rogowski M, Dazert S. The role of p21 and p53 proteins in congenital cholesteatoma. Otol Neurotol. 2013;34:266-74 pubmed 出版商
  • 免疫组化; 人类; 1:100
Ko E, Lee B, Kim Y, Lee E, Cho E, Han J, et al. Association of RASSF1A and p63 with poor recurrence-free survival in node-negative stage I-II non-small cell lung cancer. Clin Cancer Res. 2013;19:1204-12 pubmed 出版商
  • 免疫组化; 人类; 1:30
Lee E, Lee B, Ko E, Kim Y, Han J, Shim Y, et al. Cohypermethylation of p14 in combination with CADM1 or DCC as a recurrence-related prognostic indicator in stage I esophageal squamous cell carcinoma. Cancer. 2013;119:1752-60 pubmed 出版商
  • 免疫组化; 人类; 1:50
Bakry O, Hammam M, Wahed M. Immunohistochemical detection of P53 and Mdm2 in vitiligo. Indian Dermatol Online J. 2012;3:171-6 pubmed 出版商
  • 免疫组化; 人类
Piccinin S, Tonin E, Sessa S, Demontis S, Rossi S, Pecciarini L, et al. A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation. Cancer Cell. 2012;22:404-15 pubmed 出版商
  • 免疫组化; 人类; 1:200
Assmann G, Kappler R, Zeindl Eberhart E, Schmid I, Häberle B, Graeb C, et al. ?-Catenin mutations in 2 nested stromal epithelial tumors of the liver--a neoplasia with defective mesenchymal-epithelial transition. Hum Pathol. 2012;43:1815-27 pubmed 出版商
  • 免疫组化; 人类
Vallen M, Massuger L, ten Dam G, Bulten J, van Kuppevelt T. Highly sulfated chondroitin sulfates, a novel class of prognostic biomarkers in ovarian cancer tissue. Gynecol Oncol. 2012;127:202-9 pubmed 出版商
  • 免疫印迹; 小鼠; 1:500
Hardee M, Marciscano A, Medina Ramirez C, Zagzag D, Narayana A, Lonning S, et al. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-?. Cancer Res. 2012;72:4119-29 pubmed 出版商
  • 免疫组化; 人类; 1:2000
Smits A, Jin Z, Elsir T, Pedder H, Nister M, Alafuzoff I, et al. GABA-A channel subunit expression in human glioma correlates with tumor histology and clinical outcome. PLoS ONE. 2012;7:e37041 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Nout R, Bosse T, Creutzberg C, Jürgenliemk Schulz I, Jobsen J, Lutgens L, et al. Improved risk assessment of endometrial cancer by combined analysis of MSI, PI3K-AKT, Wnt/?-catenin and P53 pathway activation. Gynecol Oncol. 2012;126:466-73 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Zimmermann M, Arachchige Don A, Donaldson M, Dallapiazza R, Cowan C, Horne M. Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin. J Biol Chem. 2012;287:22838-53 pubmed 出版商
  • 免疫印迹; 人类
Suzuki M, Yamauchi M, Oka Y, Suzuki K, Yamashita S. Live-cell imaging visualizes frequent mitotic skipping during senescence-like growth arrest in mammary carcinoma cells exposed to ionizing radiation. Int J Radiat Oncol Biol Phys. 2012;83:e241-50 pubmed 出版商
  • 免疫组化-石蜡切片; 小鼠; 图 6
Simon K, Ma H, Dombkowski A, Cabelof D. Aging alters folate homeostasis and DNA damage response in colon. Mech Ageing Dev. 2012;133:75-82 pubmed 出版商
  • 免疫沉淀; 人类
Buizza L, Cenini G, Lanni C, Ferrari Toninelli G, Prandelli C, Govoni S, et al. Conformational altered p53 as an early marker of oxidative stress in Alzheimer's disease. PLoS ONE. 2012;7:e29789 pubmed 出版商
  • 免疫组化; 人类
Aydin F, Levent Y, Nilgun S, Pancar Y, Yasar T. Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy. Indian J Dermatol. 2011;56:501-4 pubmed 出版商
  • 免疫组化; 人类; 1:300
Van der Vorst S, Dekairelle A, Weynand B, Hamoir M, Gala J. Assessment of p53 functional activity in tumor cells and histologically normal mucosa from patients with head and neck squamous cell carcinoma. Head Neck. 2012;34:1542-50 pubmed 出版商
  • 免疫组化; 人类
Manganoni A, Rossi M, Sala R, Venturini M, Sereni E, Ungari M, et al. Dermoscopic, histological and immunohistochemical evaluation of cancerous features in acquired melanocytic nevi that have been repeatedly exposed to UVA or UVB. Exp Dermatol. 2012;21:86-90 pubmed 出版商
  • 免疫组化; 人类
Nemeth I, Rosztoczy A, Izbeki F, Roka R, Gecse K, Sukosd F, et al. A renewed insight into Barrett's esophagus: comparative histopathological analysis of esophageal columnar metaplasia. Dis Esophagus. 2012;25:395-402 pubmed 出版商
  • 免疫组化; 人类; 1:2000
Heusinkveld M, Goedemans R, Briet R, Gelderblom H, Nortier J, Gorter A, et al. Systemic and local human papillomavirus 16-specific T-cell immunity in patients with head and neck cancer. Int J Cancer. 2012;131:E74-85 pubmed 出版商
  • 免疫组化; 人类
Wu Y, Posner M, Schumaker L, Nikitakis N, Goloubeva O, Tan M, et al. Novel biomarker panel predicts prognosis in human papillomavirus-negative oropharyngeal cancer: an analysis of the TAX 324 trial. Cancer. 2012;118:1811-7 pubmed 出版商
  • 免疫印迹; 人类
Oka Y, Yamauchi M, Suzuki M, Yamashita S, Suzuki K. Persistence and dynamics of DNA damage signal amplification determined by microcolony formation and live-cell imaging. J Radiat Res. 2011;52:766-74 pubmed
  • 免疫组化-石蜡切片; 人类; 图 3
Kwon M, Suh Y. Pituicytoma with unusual histological features. Pathol Int. 2011;61:598-602 pubmed 出版商
  • 免疫组化; 人类; 1:200
Wolfárd A, Paszt A, Szentpali K, Hideghéthy K, Uhercsak G, Nemeth I, et al. Efficacy and drawbacks of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the thoracic esophagus. Hepatogastroenterology. 2011;58:1214-9 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:400; 表 5
Lee J, Lee K, Park J, Bae S, Lee K, Lee J, et al. Predictive factors associated with malignancy of intraductal papillary mucinous pancreatic neoplasms. World J Gastroenterol. 2010;16:5353-8 pubmed
  • 免疫印迹; 人类
Halperin R, Stafford P, Johnston S. Exploring antibody recognition of sequence space through random-sequence peptide microarrays. Mol Cell Proteomics. 2011;10:M110.000786 pubmed 出版商
  • 免疫组化; 人类; 1:50
Pfaff E, Remke M, Sturm D, Benner A, Witt H, Milde T, et al. TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma. J Clin Oncol. 2010;28:5188-96 pubmed 出版商
  • 免疫印迹; 人类
Tarjan G, Haines G, Vesper B, Xue J, Altman M, Yarmolyuk Y, et al. Part II. Initial molecular and cellular characterization of high nitric oxide-adapted human tongue squamous cell carcinoma cell lines. Tumour Biol. 2011;32:87-98 pubmed 出版商
  • 免疫组化; 人类; 1:25
Giordano G, D Adda T, Brigati F, Lombardi M, Raboni S. A Unique case of primary squamous carcinoma of the salpinx associated with serous carcinoma of the omentum: a pathological and molecular study. Int J Gynecol Pathol. 2010;29:533-8 pubmed 出版商
  • 免疫组化; 人类; 1:50; 图 5
Atha D, Manne U, Grizzle W, Wagner P, Srivastava S, Reipa V. Standards for immunohistochemical imaging: a protein reference device for biomarker quantitation. J Histochem Cytochem. 2010;58:1005-14 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 2, 3, 4
Baydar D, Kulac I, Gurel B, De Marzo A. A case of prostatic adenocarcinoma with aberrant p63 expression: presentation with detailed immunohistochemical study and FISH analysis. Int J Surg Pathol. 2011;19:131-6 pubmed 出版商
  • 免疫组化; 人类; 图 4
He J, Qiao J, Zhu H. p14ARF promoter region methylation as a marker for gliomas diagnosis. Med Oncol. 2011;28:1218-24 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:400; 表 2
Park H, Jang K, Heo J, Choi Y, Han J, Kim S. A potential case of intraductal tubulopapillary neoplasms of the bile duct. Pathol Int. 2010;60:630-5 pubmed 出版商
  • 免疫组化; 人类; 1:150
Safadi R, Al Jaber S, Hammad H, Hamasha A. Oral lichen planus shows higher expressions of tumor suppressor gene products of p53 and p21 compared to oral mucositis. An immunohistochemical study. Arch Oral Biol. 2010;55:454-61 pubmed 出版商
  • 免疫印迹; 人类; 1:200
Yang L, Xu H, Han Y, Li Q, Liu Y, Zhao Y, et al. Axin downregulates TCF-4 transcription via beta-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells. Mol Cancer. 2010;9:25 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:400; 表 4
Lee E, Kim T, Kim D, Choi C, Lee J, Lee J, et al. p53 alteration independently predicts poor outcomes in patients with endometrial cancer: a clinicopathologic study of 131 cases and literature review. Gynecol Oncol. 2010;116:533-8 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:400; 表 3
Kim S, Lee J, Park S, Park J, Lim H, Kang W, et al. The effect of DNA mismatch repair (MMR) status on oxaliplatin-based first-line chemotherapy as in recurrent or metastatic colon cancer. Med Oncol. 2010;27:1277-85 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Nielsen M, de Miranda N, van Puijenbroek M, Jordanova E, Middeldorp A, van Wezel T, et al. Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas. BMC Cancer. 2009;9:184 pubmed 出版商
  • 免疫组化; 人类
Thant A, Wu Y, Lee J, Mishra D, Garcia H, Koeffler H, et al. Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells. Anticancer Res. 2008;28:3579-92 pubmed
  • 免疫组化-石蜡切片; 人类; 图 4
Suzuki S, Takeshita K, Asamoto M, Takahashi S, Kandori H, Tsujimura K, et al. High mobility group box associated with cell proliferation appears to play an important role in hepatocellular carcinogenesis in rats and humans. Toxicology. 2009;255:160-70 pubmed 出版商
  • 免疫印迹; 人类
Hamamoto T, Suzuki K, Yamauchi M, Kodama S, Sasaki H, Watanabe M. p53 status-dependent sensitization of human tumour cells to hyperthermia by plant flavonol. Int J Hyperthermia. 2008;24:415-24 pubmed 出版商
  • 免疫印迹; 人类
Turner N, Lord C, Iorns E, Brough R, Swift S, Elliott R, et al. A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor. EMBO J. 2008;27:1368-77 pubmed 出版商
  • 免疫组化; 人类; 1:1000
Lips E, van Eijk R, de Graaf E, Doornebosch P, de Miranda N, Oosting J, et al. Progression and tumor heterogeneity analysis in early rectal cancer. Clin Cancer Res. 2008;14:772-81 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 表 3
Cho E, Choi Y, Han J, Kim K, Oh Y. Expression and amplification of Her2, EGFR and cyclin D1 in breast cancer: immunohistochemistry and chromogenic in situ hybridization. Pathol Int. 2008;58:17-25 pubmed
  • 免疫组化-石蜡切片; 人类; 图 2
Barzilai A, Lyakhovitsky A, Trau H, Fogel M, Huszar M. Expression of p53 in the evolution of squamous cell carcinoma: correlation with the histology of the lesion. J Am Acad Dermatol. 2007;57:669-76 pubmed
  • 免疫组化; 人类; 1:25
Giordano G, D Adda T, Gnetti L, Merisio C, Raboni S. Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature. Int J Gynecol Pathol. 2007;26:298-304 pubmed
  • 免疫印迹; 小鼠; 1:1000
Ray S, Chatterjee A. Influence of glutathione on the induction of chromosome aberrations, delay in cell cycle kinetics and cell cycle regulator proteins in irradiated mouse bone marrow cells. Int J Radiat Biol. 2007;83:347-54 pubmed
  • 免疫组化; 人类; 1:50
Giordano G, D Adda T, Gnetti L, Merisio C, Gabrielli M, Melpignano M. Villoglandular adenocarcinoma of the cervix: two new cases with morphological and molecular study. Int J Gynecol Pathol. 2007;26:199-204 pubmed
  • 酶联免疫吸附测定; 人类
Rossner P, Binkova B, Milcova A, Solansky I, Zidzik J, Lyubomirova K, et al. Air pollution by carcinogenic PAHs and plasma levels of p53 and p21(WAF1) proteins. Mutat Res. 2007;620:34-40 pubmed
  • 免疫印迹; 人类; 1:500
Schumacher G, Scheunert S, Rueggeberg A, Bachem M, Nussler A, Spinelli A, et al. A very low toxic agent induces apoptosis and reduces growth of human hepatocellular carcinoma cells. J Gastroenterol Hepatol. 2006;21:1207-12 pubmed
  • 免疫组化; 人类; 1:50
Seidman J, Kumar D, Cosin J, Winter W, Cargill C, Boice C. Carcinomas of the female genital tract occurring after pelvic irradiation: a report of 15 cases. Int J Gynecol Pathol. 2006;25:293-7 pubmed
  • 免疫组化-石蜡切片; 人类; 1:150; 图 1
Cho E, Choi Y, Chae S, Sohn J, Ahn G. Relationship between p53-associated proteins and estrogen receptor status in ovarian serous neoplasms. Int J Gynecol Cancer. 2006;16:1000-6 pubmed
  • 免疫组化-石蜡切片; 人类; 1:50
Kim K, Park E, Seo Y, Cho H, Kim C, Kim K, et al. Immunohistochemical study of cyclooxygenase-2 and p53 expression in skin tumors. J Dermatol. 2006;33:319-25 pubmed
  • 免疫印迹; 人类; 图 9
Pizzimenti S, Briatore F, Laurora S, Toaldo C, Maggio M, De Grandi M, et al. 4-Hydroxynonenal inhibits telomerase activity and hTERT expression in human leukemic cell lines. Free Radic Biol Med. 2006;40:1578-91 pubmed
  • 免疫组化; 人类; 1:50
Lee M, Suh C, Li Z. Clinicopathological significance of maspin expression in breast cancer. J Korean Med Sci. 2006;21:309-14 pubmed
  • 免疫细胞化学; 人类; 1:2000
Suzuki M, Suzuki K, Kodama S, Watanabe M. Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest. Biochem Biophys Res Commun. 2006;340:145-50 pubmed
  • 免疫组化-石蜡切片; 人类; 1:100
Yakirevich E, Sabo E, Naroditsky I, Sova Y, Lavie O, Resnick M. Multidrug resistance-related phenotype and apoptosis-related protein expression in ovarian serous carcinomas. Gynecol Oncol. 2006;100:152-9 pubmed
  • 免疫组化; 小鼠; 1:100
  • 免疫印迹; 小鼠
Osada M, Nagakawa Y, Park H, Yamashita K, Wu G, Kim M, et al. p63-specific activation of the BPAG-1e promoter. J Invest Dermatol. 2005;125:52-60 pubmed
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Yamauchi M, Suzuki K, Kodama S, Watanabe M. Abnormal stability of wild-type p53 protein in a human lung carcinoma cell line. Biochem Biophys Res Commun. 2005;330:483-8 pubmed
  • 免疫组化-石蜡切片; 人类; 表 4
Gumus E, Erdamar S, Demirel G, Horasanli K, Kendirci M, Miroglu C. Association of positive serum anti-p53 antibodies with poor prognosis in bladder cancer patients. Int J Urol. 2004;11:1070-7 pubmed
  • 免疫细胞化学; 人类
Torkin R, Lavoie J, Kaplan D, Yeger H. Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma. Mol Cancer Ther. 2005;4:1-11 pubmed
  • 免疫印迹; 人类; 图 5
Laurora S, Tamagno E, Briatore F, Bardini P, Pizzimenti S, Toaldo C, et al. 4-Hydroxynonenal modulation of p53 family gene expression in the SK-N-BE neuroblastoma cell line. Free Radic Biol Med. 2005;38:215-25 pubmed
  • 免疫组化-石蜡切片; 人类; 1:60; 图 1
Bar Sela G, Ben Arush M, Sabo E, Kuten A, Minkov I, Ben Izhak O. Pediatric nasopharyngeal carcinoma: better prognosis and increased c-Kit expression as compared to adults. Pediatr Blood Cancer. 2005;45:291-7 pubmed
  • 免疫组化-石蜡切片; 人类; 1:50; 表 1
Park H, Min S, Cho H, Kim K, Shin H, Park Y. Expression profiles of p63, p53, survivin, and hTERT in skin tumors. J Cutan Pathol. 2004;31:544-9 pubmed
  • 免疫组化-石蜡切片; 人类; 1:400; 表 1
Song S, Park S, Kim S, Suh Y. Oncocytic adrenocortical carcinomas: a pathological and immunohistochemical study of four cases in comparison with conventional adrenocortical carcinomas. Pathol Int. 2004;54:603-10 pubmed
  • 免疫组化-石蜡切片; 人类; 1:250
Kim N, Wang K, Bang J, Choe G, Park Y, Kim S, et al. Glioblastomatous transformation of ganglioglioma: case report with reference to molecular genetic and flow cytometric analysis. Pathol Int. 2003;53:874-82 pubmed
  • 免疫细胞化学; 猕猴; 图 9
  • 免疫细胞化学; 人类; 图 9
Mathur M, Das S, Samuels H. PSF-TFE3 oncoprotein in papillary renal cell carcinoma inactivates TFE3 and p53 through cytoplasmic sequestration. Oncogene. 2003;22:5031-44 pubmed
  • 免疫组化-石蜡切片; 人类; 1:50; 图 5
Li C, Hirokawa M, Qian Z, Fujii Y, Ino H, Wakatsuki S, et al. Morules with optically clear nuclei in ovarian borderline endometrioid tumor. APMIS. 2002;110:783-8 pubmed
  • 免疫组化-石蜡切片; 人类
Lee S, Park C, Sung C, Choi J, Oh Y, Cho J, et al. Correlation of mutation and immunohistochemistry of p53 in hepatocellular carcinomas in Korean people. J Korean Med Sci. 2002;17:801-5 pubmed
  • 免疫细胞化学; 人类
Rheinwald J, Hahn W, Ramsey M, Wu J, Guo Z, Tsao H, et al. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol Cell Biol. 2002;22:5157-72 pubmed
  • 免疫组化-石蜡切片; 人类
Kang Y, Kim K, Yu Y, Lim S, Kim Y, Park K. The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer. J Korean Med Sci. 2001;16:417-23 pubmed
  • 免疫组化-石蜡切片; 人类; 1:50
Park Y, Park H, Chi S, Ushigome S, Unni K. Overexpression of p53 and absent genetic mutation in clear cell chondrosarcoma. Int J Oncol. 2001;19:353-7 pubmed
  • 免疫组化-石蜡切片; 人类; 图 1B
Chowers I, Pe er J, Zamir E, Livni N, Ilsar M, Frucht Pery J. Proliferative activity and p53 expression in primary and recurrent pterygia. Ophthalmology. 2001;108:985-8 pubmed
  • 免疫细胞化学; 人类
Dickson M, Hahn W, Ino Y, Ronfard V, Wu J, Weinberg R, et al. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol. 2000;20:1436-47 pubmed
  • 免疫组化-石蜡切片; 人类; 1 ug/ml; 图 1
Tashima S, Shimada S, Yamaguchi K, Tsuruta J, Ogawa M. Expression of brain-type glycogen phosphorylase is a potentially novel early biomarker in the carcinogenesis of human colorectal carcinomas. Am J Gastroenterol. 2000;95:255-63 pubmed
  • 免疫组化-石蜡切片; 人类
Shiga H, Heath E, Rasmussen A, Trock B, Johnston P, Forastiere A, et al. Prognostic value of p53, glutathione S-transferase pi, and thymidylate synthase for neoadjuvant cisplatin-based chemotherapy in head and neck cancer. Clin Cancer Res. 1999;5:4097-104 pubmed
  • 免疫细胞化学; 人类; 表 4
Bradford C, Wolf G, Carey T, Zhu S, Beals T, Truelson J, et al. Predictive markers for response to chemotherapy, organ preservation, and survival in patients with advanced laryngeal carcinoma. Otolaryngol Head Neck Surg. 1999;121:534-8 pubmed
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1, 2
Hodak E, Hammel I, Feinmesser M, Zelinger A, Maron L, Sulkes J, et al. Differential expression of p53 and Ki-67 proteins in classic and iatrogenic Kaposi's sarcoma. Am J Dermatopathol. 1999;21:138-45 pubmed
  • 免疫组化; 人类; 1:10; 图 5
Nikol S, Huehns T, Weir L, Wight T, Hofling B. Restenosis in human vein bypass grafts. Atherosclerosis. 1998;139:31-9 pubmed
  • 免疫组化-石蜡切片; 人类
Mateo M, Sanchez Beato M, Martinez J, Orfao A, Orradre J, Piris M. p53, Rb and bcl-2 expression during the cell cycle: a study in phytohaemagglutinin stimulated lymphocytes and microwave irradiated lymphoid tissue sections. J Clin Pathol. 1995;48:151-9 pubmed
  • 免疫组化-石蜡切片; 人类
Livni N, Eid A, Ilan Y, Rivkind A, Rosenmann E, Blendis L, et al. p53 expression in patients with cirrhosis with and without hepatocellular carcinoma. Cancer. 1995;75:2420-6 pubmed
Ahmad F, Leake D. Lysosomal oxidation of LDL alters lysosomal pH, induces senescence, and increases secretion of pro-inflammatory cytokines in human macrophages. J Lipid Res. 2019;60:98-110 pubmed 出版商
Jeong Y, Park S, Mun S, Kwak S, Lee S, Oh H. Association between lysyl oxidase and fibrotic focus in relation with inflammation in breast cancer. Oncol Lett. 2018;15:2431-2440 pubmed 出版商
Hackeng W, Montgomery E, Giardiello F, Singhi A, Debeljak M, Eshleman J, et al. Morphology and genetics of pyloric gland adenomas in familial adenomatous polyposis. Histopathology. 2017;70:549-557 pubmed 出版商
Gillory L, Stewart J, Megison M, Waters A, Beierle E. Focal adhesion kinase and p53 synergistically decrease neuroblastoma cell survival. J Surg Res. 2015;196:339-49 pubmed 出版商
Zhang Y, Zhou L, Rouge L, Phillips A, Lam C, Liu P, et al. Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7. Nat Chem Biol. 2013;9:51-8 pubmed 出版商
Li Z, Day C, Yang J, Tsai W, Lozano G, Shih H, et al. Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53. Cancer Res. 2004;64:9080-5 pubmed
Milne A, Carvalho R, van Rees B, van Lanschot J, Offerhaus G, Weterman M. Do collision tumors of the gastroesophageal junction exist? A molecular analysis. Am J Surg Pathol. 2004;28:1492-8 pubmed
Fomenkov A, Zangen R, Huang Y, Osada M, Guo Z, Fomenkov T, et al. RACK1 and stratifin target DeltaNp63alpha for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage. Cell Cycle. 2004;3:1285-95 pubmed
Yamauchi M, Suzuki K, Kodama S, Watanabe M. Stabilization of alanine substituted p53 protein at Ser15, Thr18, and Ser20 in response to ionizing radiation. Biochem Biophys Res Commun. 2004;323:906-11 pubmed
Tokumaru Y, Yamashita K, Osada M, Nomoto S, Sun D, Xiao Y, et al. Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing. Cancer Res. 2004;64:5982-7 pubmed
Tulunay O, Gogus C, Baltaci S, Bulut S. Clear cell adenocarcinoma of the tunica vaginalis of the testis with an adjacent uterus-like tissue. Pathol Int. 2004;54:641-7 pubmed
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller A, Caruso A, et al. Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. J Neurosci. 2004;24:6021-7 pubmed
Tabs S, Avci O. Induction of the differentiation and apoptosis of tumor cells in vivo with efficiency and selectivity. Eur J Dermatol. 2004;14:96-102 pubmed
Roberts K, Bhatia K, Stanton P, Lord R. Proteomic analysis of selected prognostic factors of breast cancer. Proteomics. 2004;4:784-92 pubmed
Deveci M, Deveci G. Altered distribution of metaplastic Paneth, gastrin and pancreatic acinar cells in atrophic gastritic mucosa with endocrine cell lesions. Tohoku J Exp Med. 2004;202:13-22 pubmed
Alami J, Williams B, Yeger H. Derivation and characterization of a Wilms' tumour cell line, WiT 49. Int J Cancer. 2003;107:365-74 pubmed
Hamada N, Kodama S, Suzuki K, Watanabe M. Gap junctional intercellular communication and cellular response to heat stress. Carcinogenesis. 2003;24:1723-8 pubmed
Mascaux C, Martin B, Verdebout J, Meert A, Ninane V, Sculier J. Fragile histidine triad protein expression in nonsmall cell lung cancer and correlation with Ki-67 and with p53. Eur Respir J. 2003;21:753-8 pubmed
Campas C, Dalmau M, Montaner B, Barragan M, Bellosillo B, Colomer D, et al. Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia. Leukemia. 2003;17:746-50 pubmed
Campas C, Lopez J, Santidrian A, Barragan M, Bellosillo B, Colomer D, et al. Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. Blood. 2003;101:3674-80 pubmed
DiRenzo J, Signoretti S, Nakamura N, Rivera Gonzalez R, Sellers W, Loda M, et al. Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line. Cancer Res. 2002;62:89-98 pubmed
Suzuki K, Kodama S, Watanabe M. Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation. J Biol Chem. 1999;274:25571-5 pubmed
Ghosh J, Suzuki K, Kodama S, Watanabe M. Effects of protein kinase inhibitors on the accumulation kinetics of p53 protein in normal human embryo cells following X-irradiation. J Radiat Res. 1999;40:23-37 pubmed
图像
图像 1 :
赛默飞世尔 MA1-19055 图像 1
产品信息
产品类型 :
抗体
产品名称 :
p53单克隆抗体(BP53-12)
目录# :
MA1-19055
规格 :
100微克
价格 :
美国425.00
克隆性 :
单克隆
纯度 :
selective precipitation
宿主 :
小鼠
反应物种 :
Human, Non-human primate
应用 :
ELISA: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1-2 µg/mL
物种 :
Human, Non-human primate
克隆 :
BP53-12
抗体亚型 :
IgG2a
储存 :
4° C, 不冻结
描述 :
The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. p53 has been characterized to play a role in blocking the proliferative action of damaged cells and act as an anticancer agent. Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors. In addition, p53 has also been linked to the effects of aging and oxidative stress and an increase in p53 has been linked to deficits in LTP (Long Term Potentiation) in learning and memory. p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome.
免疫原 :
Bacterially expressed full-length wild-type p53
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1-2 µg/mL
别名 :
Antigen NY-CO-13; bbl; BCC7; bfy; bhy; cellular tumor antigen p53; Cys 51 Stop; EGK_08142; FLJ92943; HGNC11998; I79_002739; LFS1; Li-Fraumeni syndrome; mutant p53; mutant tumor protein 53; OTTMUSP00000006194; p44; p53; p53 cellular tumor antigen; p53 protein; p53 tumor suppressor; p53 tumor suppressor phosphoprotein; phosphoprotein p53; Tp53; tp53.L; transformation related protein 53; transformation-related protein 53; Trp248; Trp53; tumor protein 53; tumor protein p53; tumor protein p53 (Li-Fraumeni syndrome); tumor protein p53 L homeolog; tumor suppressor p53; tumor suppressor p53 phosphoprotein; tumor suppressor protein p53; tumor supressor p53; Tumour Protein p53; XELAEV_180196761mg; Xp53; Xrel3
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国