产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD59单克隆抗体(最小必需培养基-43)
目录 :
MA1-19133
规格 :
100微克
价格 :
美国321.00
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
最小必需培养基-43
反应物种 :
人类, pigs , 猕猴
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
赛默飞世尔 产品网页
文章摘录数: 18
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 s2
Puhka M, Nordberg M, Valkonen S, Rannikko A, Kallioniemi O, Siljander P, et al. KeepEX, a simple dilution protocol for improving extracellular vesicle yields from urine. Eur J Pharm Sci. 2017;98:30-39 pubmed 出版商
  • 免疫细胞化学; pigs ; 1:100; 图 1b
  • 免疫印迹; pigs ; 1:500; 图 s1f
Tan L, Toops K, Lakkaraju A. Protective responses to sublytic complement in the retinal pigment epithelium. Proc Natl Acad Sci U S A. 2016;113:8789-94 pubmed 出版商
  • 免疫沉淀; 人类; 图 3a
LaRocca T, Stivison E, Mal Sarkar T, Hooven T, Hod E, Spitalnik S, et al. CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis. Cell Death Dis. 2015;6:e1773 pubmed 出版商
  • 流式细胞仪; 猕猴; 图 1
Byrnes C, Terry Lee Y, Donahue R, Miller J. Identification of a cross-reacting, monoclonal anti-human CD233 antibody for identification and sorting of rhesus macaque erythrocytes. Cytometry A. 2012;81:165-8 pubmed 出版商
  • 免疫细胞化学; 人类
Barcena A, Muench M, Kapidzic M, Gormley M, Goldfien G, Fisher S. Human placenta and chorion: potential additional sources of hematopoietic stem cells for transplantation. Transfusion. 2011;51 Suppl 4:94S-105S pubmed 出版商
  • 流式细胞仪; 人类; 图 2
Borowitz M, Craig F, DiGiuseppe J, Illingworth A, Rosse W, Sutherland D, et al. Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry. Cytometry B Clin Cytom. 2010;78:211-30 pubmed 出版商
  • 流式细胞仪; 人类
Willcocks L, Lyons P, Clatworthy M, Robinson J, Yang W, Newland S, et al. Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake. J Exp Med. 2008;205:1573-82 pubmed 出版商
  • 流式细胞仪; 人类
Williams M, Densmore J, Pawluczkowycz A, Beum P, Kennedy A, Lindorfer M, et al. Thrice-weekly low-dose rituximab decreases CD20 loss via shaving and promotes enhanced targeting in chronic lymphocytic leukemia. J Immunol. 2006;177:7435-43 pubmed
  • 流式细胞仪; 人类
Zucchetto A, Sonego P, Degan M, Bomben R, Dal Bo M, Russo S, et al. Signature of B-CLL with different prognosis by Shrunken centroids of surface antigen expression profiling. J Cell Physiol. 2005;204:113-23 pubmed
  • 流式细胞仪; 人类
Thomason R, Papiez J, Lee R, Szczarkowski W. Identification of unsuspected PNH-type cells in flow cytometric immunophenotypic analysis of peripheral blood and bone marrow. Am J Clin Pathol. 2004;122:128-34 pubmed
  • 流式细胞仪; 人类
Suskind D, Muench M. Searching for common stem cells of the hepatic and hematopoietic systems in the human fetal liver: CD34+ cytokeratin 7/8+ cells express markers for stellate cells. J Hepatol. 2004;40:261-8 pubmed
  • 免疫组化; 人类
Fierro M, Savoia P, Quaglino P, Novelli M, Barberis M, Bernengo M. Systemic therapy with cyclophosphamide and anti-CD20 antibody (rituximab) in relapsed primary cutaneous B-cell lymphoma: a report of 7 cases. J Am Acad Dermatol. 2003;49:281-7 pubmed
  • 免疫沉淀; 人类; 图 1
Solomon K, Rudd C, Finberg R. The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes. Proc Natl Acad Sci U S A. 1996;93:6053-8 pubmed
  • 免疫印迹; 人类; 图 4
Koski C, Estep A, Sawant Mane S, Shin M, Highbarger L, Hansch G. Complement regulatory molecules on human myelin and glial cells: differential expression affects the deposition of activated complement proteins. J Neurochem. 1996;66:303-12 pubmed
  • 免疫沉淀; 人类
Tseng J, Hall S, Howard T, Ware R. Phenotypic and functional analysis of lymphocytes in paroxysmal nocturnal hemoglobinuria. Am J Hematol. 1995;50:244-53 pubmed
  • 流式细胞仪; 人类
Philbrick W, Palfree R, Maher S, Bridgett M, Sirlin S, Bothwell A. The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility. Eur J Immunol. 1990;20:87-92 pubmed
Sartain S, Turner N, Moake J. TNF Regulates Essential Alternative Complement Pathway Components and Impairs Activation of Protein C in Human Glomerular Endothelial Cells. J Immunol. 2016;196:832-45 pubmed 出版商
Liew M, Farley M, Andreasen J, Parker C, Wittwer C. Rare event counting of CD59- red cells in human blood: A 47-month experience using PNH consensus guidelines for WBC and RBC testing in a reference lab. Cytometry B Clin Cytom. 2015;88:261-9 pubmed 出版商
图像
图像 1 :
赛默飞世尔 MA1-19133 图像 1
产品信息
产品类型 :
抗体
产品名称 :
CD59单克隆抗体(最小必需培养基-43)
目录# :
MA1-19133
规格 :
100微克
价格 :
美国321.00
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 1-2 µg/mL, Immunohistochemistry (Paraffin): 10 µg/mL, Immunoprecipitation: Assay-dependent
物种 :
人类
克隆 :
最小必需培养基-43
抗体亚型 :
IgG2a
储存 :
4° C, 不冻结
描述 :
CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). CD59 is the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 also associates with C5b-8 complex and counteracts appropriate formation of cytolytic pore within the plasma membrane. Further, CD59 is a low-affinity ligand of human CD2, causes T cell costimulation, and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. Mutations in this gene cause CD59 deficiency, a disease involving hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants of CD59 have been identified.
免疫原 :
Thymocytes and T lymphocytes.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 1-2 µg/mL, Immunohistochemistry (Paraffin): 10 µg/mL, Immunoprecipitation: Assay-dependent
别名 :
16.3A5; 1F5; 1F5 antigen; 20 kDa homologous restriction factor; AA987121; Cb59b molecule; CD59; CD59 antigen; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344); CD59 glycoprotein; CD59 molecule; CD59 molecule (CD59 blood group); CD59 molecule, complement regulatory protein; Cd59a; CD59a antigen; CD59A glycoprotein; Cd59b; CD59b antigen; CD59B glycoprotein; CD59b moleucle, complement regulatory protein; complement inhibitor CD59; complement regulatory protein; EJ16; EJ30; EL32; G344; HRF20; HRF-20; human leukocyte antigen MIC11; Ly-6-like protein; lymphocytic antigen CD59/MEM43; MACIF; MAC-inhibitory protein; MACIP; MAC-IP; MEM43; MEM43 antigen; membrane attack complex (MAC) inhibition factor; membrane attack complex inhibition factor; Membrane inhibitor of reactive lysis; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20; protectin; surface anitgen recognized by monoclonal antibody 16.3A5; T cell-activating protein
更多信息或购买 :
赛默飞世尔 产品网页
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国