产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
CD27单克隆抗体(LT27)
目录 :
MA1-19245
规格 :
100微克
价格 :
美国366
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
LT27
反应物种 :
人类
应用 :
流式细胞仪, 抑制或激活实验
更多信息或购买 :
文章摘录数: 1
| 出版应用/物种/样本/稀释 | 参考文献 |
|---|---|
| Pace K, Lee C, Stewart P, Baum L. Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1. J Immunol. 1999;163:3801-11 pubmed
|
图像
图像 1 :
产品信息
产品类型 :
抗体
产品名称 :
CD27单克隆抗体(LT27)
目录# :
MA1-19245
规格 :
100微克
价格 :
美国366
克隆性 :
单克隆
纯度 :
离子交换层析
宿主 :
小鼠
反应物种 :
人类
应用 :
Flow Cytometry: 2 µg/mL
物种 :
人类
克隆 :
LT27
抗体亚型 :
IgG2a
储存 :
4° C, 不冻结
描述 :
CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. The TNF superfamily members are known for the regulation of cell proliferation and death. In contrast to the expression of other TNFR/TNF family members, expression of CD27 and its ligand CD70 is predominantly confined to lymphocytes. High expression levels of CD27 appear to be dependent on proper ligation of antigen receptors. CD70 expression requires additional co-stimulatory and/or pro-inflammatory signals. CD27 is expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. Soluble CD27 is an important prognostic marker of acute and chronic B cell malignancies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and its ligand CD70. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.
免疫原 :
Human peripheral blood lymphocytes.
格式 :
液体
应用w/稀释 :
Flow Cytometry: 2 µg/mL
别名 :
CD antigen 27; CD27; CD27 antigen; CD27 molecule; CD27L receptor; S152; S152. LPFS2; sCD27; soluble CD27; T cell activation antigen S152; T14; T-cell activation antigen CD27; Tnfrsf7; Tp55; Tumor necrosis factor receptor superfamily member 7; tumor necrosis factor receptor superfamily, member 7
更多信息或购买 :
公司信息
赛默飞世尔