产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
表皮生长因子受体单克隆抗体(F4)
目录 :
MA1-24226
规格 :
100微克
价格 :
美国475
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
F4
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 17
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 人类; 1:50
Baek K, Hong M, Jung Y, Lee C, Lee T, Park E, et al. Correlation of AR, EGFR, and HER2 Expression Levels in Prostate Cancer: Immunohistochemical Analysis and Chromogenic In Situ Hybridization. Cancer Res Treat. 2012;44:50-6 pubmed 出版商
  • 免疫组化; 人类
Linder N, Konsti J, Turkki R, Rahtu E, Lundin M, Nordling S, et al. Identification of tumor epithelium and stroma in tissue microarrays using texture analysis. Diagn Pathol. 2012;7:22 pubmed 出版商
  • 免疫组化; 人类
Mackiewicz M, Huppi K, Pitt J, Dorsey T, Ambs S, Caplen N. Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA. Breast Cancer Res Treat. 2011;130:663-79 pubmed 出版商
  • 免疫组化; 人类
Glynn S, Boersma B, Dorsey T, Yi M, Yfantis H, Ridnour L, et al. Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients. J Clin Invest. 2010;120:3843-54 pubmed 出版商
  • 免疫组化; 人类
Martin D, Boersma B, Yi M, Reimers M, Howe T, Yfantis H, et al. Differences in the tumor microenvironment between African-American and European-American breast cancer patients. PLoS ONE. 2009;4:e4531 pubmed 出版商
  • 免疫组化; 人类; 1:100
Li H, Zhou G, Fu X, Zhang L. Antigen expression of human eccrine sweat glands. J Cutan Pathol. 2009;36:318-24 pubmed 出版商
  • 免疫组化; 人类
Schiavo R, Tullio C, La Grotteria M, Andreotti I, Scarpati B, Romiti L, et al. Establishment and characterization of a new Ewing's sarcoma cell line from a malignant pleural effusion. Anticancer Res. 2007;27:3273-8 pubmed
  • 免疫组化; 人类; 1:50
Jin J, Wu C, Lin Y, Wang J, Yu C, Sheu L, et al. Higher expression of epidermal growth factor receptor is associated with extracellular matrix metalloprotease inducer in colorectal adenocarcinoma: tissue microarray analysis of immunostaining score with clinicopathological parameters. Dis Markers. 2006;22:309-16 pubmed
  • 免疫组化; 人类
Wang S, Nakajima Y, Yu Y, Xia W, Chen C, Yang C, et al. Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Biol. 2006;8:1359-68 pubmed
  • 免疫组化; 人类; 1:50
Avninder S, Sharma M, Deb P, Mehta V, Karak A, Mahapatra A, et al. Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations--a study of 32 cases. J Neurooncol. 2006;78:123-7 pubmed
  • 免疫组化; 人类; 1:50
Rayala S, Hollander P, Balasenthil S, Molli P, Bean A, Vadlamudi R, et al. Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) interacts with PELP1 and activates MAPK. J Biol Chem. 2006;281:4395-403 pubmed
  • 免疫印迹; 人类
Pangburn H, Kraus H, Ahnen D, Rice P. Sulindac metabolites inhibit epidermal growth factor receptor activation and expression. J Carcinog. 2005;4:16 pubmed
Hajdu T, Váradi T, Rebenku I, Kovacs T, Szollosi J, Nagy P. Comprehensive Model for Epidermal Growth Factor Receptor Ligand Binding Involving Conformational States of the Extracellular and the Kinase Domains. Front Cell Dev Biol. 2020;8:776 pubmed 出版商
Tanimura K, Nakago S, Murakoshi H, Takekida S, Moriyama T, Matsuo H, et al. Changes in the expression and cytological localization of betacellulin and its receptors (ErbB-1 and ErbB-4) in the trophoblasts in human placenta over the course of pregnancy. Eur J Endocrinol. 2004;151:93-101 pubmed
Chen Z, de Paiva C, Luo L, Kretzer F, Pflugfelder S, Li D. Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells. 2004;22:355-66 pubmed
Matalliotakis I, Goumenou A, Koumantakis G, Athanassakis I, Dionyssopoulou E, Neonaki M, et al. Expression of serum human leukocyte antigen and growth factor levels in a Greek family with familial endometriosis. J Soc Gynecol Investig. 2003;10:118-21 pubmed
Matalliotakis I, Goumenou A, Koumantakis G, Neonaki M, Koumantakis E, Dionyssopoulou E, et al. Serum concentrations of growth factors in women with and without endometriosis: the action of anti-endometriosis medicines. Int Immunopharmacol. 2003;3:81-9 pubmed
产品信息
产品类型 :
抗体
产品名称 :
表皮生长因子受体单克隆抗体(F4)
目录# :
MA1-24226
规格 :
100微克
定价 :
美国475
克隆性 :
单克隆
纯度 :
蛋白质A
宿主 :
小鼠
反应物种 :
人类
应用 :
ELISA: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: Assay-dependent, Radioimmune assays: Assay-dependent, Western Blot: 1 µg/mL
物种 :
人类
克隆 :
F4
抗体亚型 :
IgG1
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
EGFR (Epidermal growth factor receptor, HER1, ErbB1) is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Phosphorylation of EGFR at certain residues is also mediated by Src-non-receptor kinase. EGFR activation signals multiple downstream signaling cascades such as the Ras - ERK, PI3-K - Akt, Jak - STAT and PKC pathways that help in growth and proliferation of cells. Phosphorylation of EGFR at Y1086 specifically allows binding of the adaptor protein GRB2, leading to activation of the MAPK pathway. Upon receptor activation and signaling, EGFR is endocytosed and targeted for degradation or recycling. Mutations in the EGFR gene are associated with lung cancer and multiple alternatively spliced transcript variants encode different protein isoforms of EGFR have been found. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. Moreover, EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
免疫原 :
合成多肽对应于氨基酸残基D(985)V V D A D E Y L I P Q(996)人的表皮生长因子受体
格式 :
液体
应用w/稀释 :
ELISA: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: Assay-dependent, Radioimmune assays: Assay-dependent, Western Blot: 1 µg/mL
别名 :
2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国