产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
酪氨酸羟化酶单克隆抗体(185)
目录 :
MA1-24654
规格 :
50微升
价格 :
美国472
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
185
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 10
出版应用/物种/样本/稀释参考文献
  • 免疫组化; 人类; 1:400
Okoshi Y, Tanuma N, Miyata R, Hayashi M. Melatonin alterations and brain acetylcholine lesions in sleep disorders in Cockayne syndrome. Brain Dev. 2014;36:907-13 pubmed 出版商
  • 免疫组化; 人类; 1:400
Okoshi Y, Hayashi M, Kanda S, Yamamoto T. An autopsy case of microencephaly, bizarre putaminal lesion, and cerebellar atrophy with heart and liver diseases. Brain Dev. 2014;36:707-10 pubmed 出版商
  • 免疫组化; 人类; 1:400
Hayashi M, Nakajima K, Miyata R, Tanuma N, Kodama T. Lesions of acetylcholine neurons in refractory epilepsy. ISRN Neurol. 2012;2012:404263 pubmed 出版商
  • 免疫组化; 大鼠
Lundgren O, Jodal M, Jansson M, Ryberg A, Svensson L. Intestinal epithelial stem/progenitor cells are controlled by mucosal afferent nerves. PLoS ONE. 2011;6:e16295 pubmed 出版商
  • 免疫组化; 人类; 1:400
Hayashi M, Hachiya Y, Arai N. An autopsy case presenting repetitive hypoglycemia and unique cortical dysplasia. Brain Dev. 2010;32:289-92 pubmed 出版商
Garcia DuBar S, Cosio D, Korthas H, Van Batavia J, Zderic S, Sahibzada N, et al. Somatostatin Neurons in the Mouse Pontine Nucleus Activate GABAA Receptor Mediated Synaptic Currents in Locus Coeruleus Neurons. Front Synaptic Neurosci. 2021;13:754786 pubmed 出版商
Cui K, Yang F, Tufan T, Raza M, Zhan Y, Fan Y, et al. Restoration of Noradrenergic Function in Parkinson's Disease Model Mice. ASN Neuro. 2021;13:17590914211009730 pubmed 出版商
Keck S, Galati Fournier V, Kym U, Moesch M, Usemann J, Muller I, et al. Lack of Mucosal Cholinergic Innervation Is Associated With Increased Risk of Enterocolitis in Hirschsprung's Disease. Cell Mol Gastroenterol Hepatol. 2021;12:507-545 pubmed 出版商
KEARNEY M, Warren T, Hisey E, Qi J, Mooney R. Discrete Evaluative and Premotor Circuits Enable Vocal Learning in Songbirds. Neuron. 2019;104:559-575.e6 pubmed 出版商
Zhou Q, Song Y, Huang C, Huang J, Gong Z, Liao Z, et al. Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release. Mol Cell Biol. 2018;38: pubmed 出版商
产品信息
产品类型 :
抗体
产品名称 :
酪氨酸羟化酶单克隆抗体(185)
目录# :
MA1-24654
规格 :
50微升
定价 :
美国472
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
人类, 小鼠, 大鼠
应用 :
Immunocytochemistry: 1:50, Immunohistochemistry (Frozen): 1:20-1:40, Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: 1:25-1:50
物种 :
人类, 小鼠, 大鼠
克隆 :
185
抗体亚型 :
IgG2a
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
免疫原 :
Recombinant protein corresponding to the C-terminal portion of mouse Tyrosine Hydroxylase.
格式 :
液体
应用w/稀释 :
Immunocytochemistry: 1:50, Immunohistochemistry (Frozen): 1:20-1:40, Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: 1:25-1:50
别名 :
dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国