产品简要
公司名称 :
赛默飞世尔
其他品牌 :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
产品类型 :
抗体
产品名称 :
细胞周期蛋白D1单克隆抗体(DCS-6)
目录 :
MA1-24750
规格 :
100微升
价格 :
美国435
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
DCS-6
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 免疫组化-冰冻切片
更多信息或购买 :
文章摘录数: 146
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 4
Tian L, Wang C, Hagen F, Gormley M, Addya S, Soccio R, et al. Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells. Oncotarget. 2014;5:7303-15 pubmed
  • 免疫印迹; 人类; 1:1000; 图 1e
Ormanns S, Neumann J, Horst D, Kirchner T, Jung A. WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear ?-Catenin depend on active PI3K signaling. Oncotarget. 2014;5:2999-3011 pubmed
  • 免疫组化; 人类; 1:400
Do S, Kim K, Lee H, Kim H, Do T, Yun J, et al. Aberrant expression pattern and location of cullin 1 are associated with the development of papillary carcinoma in thyroid and cyclin D1 expression. Endocr Pathol. 2014;25:282-7 pubmed 出版商
  • 免疫印迹; 小鼠
Cerqueira A, Martin A, Symonds C, Odajima J, Dubus P, Barbacid M, et al. Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors. Mol Cell Biol. 2014;34:1452-9 pubmed 出版商
  • 免疫组化; 人类; 1:50
Wang H, Wang H, Makki M, Wen J, Dai Y, Shi Q, et al. Overexpression of ?-catenin and cyclinD1 predicts a poor prognosis in ovarian serous carcinomas. Int J Clin Exp Pathol. 2014;7:264-71 pubmed
  • 免疫印迹; 人类
Elong Edimo W, Schurmans S, Roger P, Erneux C. SHIP2 signaling in normal and pathological situations: Its impact on cell proliferation. Adv Biol Regul. 2014;54:142-51 pubmed 出版商
  • 免疫印迹; 小鼠
Shukla S, Bhaskaran N, Babcook M, Fu P, MacLennan G, Gupta S. Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway. Carcinogenesis. 2014;35:452-60 pubmed 出版商
  • 免疫印迹; 人类
Du Q, Zhang X, Liu Q, Zhang X, Bartels C, Geller D. Nitric oxide production upregulates Wnt/?-catenin signaling by inhibiting Dickkopf-1. Cancer Res. 2013;73:6526-37 pubmed 出版商
  • 免疫组化; 人类; 1:25
Wake N, Ricketts C, Morris M, Prigmore E, Gribble S, Skytte A, et al. UBE2QL1 is disrupted by a constitutional translocation associated with renal tumor predisposition and is a novel candidate renal tumor suppressor gene. Hum Mutat. 2013;34:1650-61 pubmed 出版商
  • 免疫组化; 大鼠; 1:500
  • 免疫印迹; 大鼠; 1:500
Wu J, Raver C, Piao C, Keller A, Faden A. Cell cycle activation contributes to increased neuronal activity in the posterior thalamic nucleus and associated chronic hyperesthesia after rat spinal cord contusion. Neurotherapeutics. 2013;10:520-38 pubmed 出版商
  • 免疫印迹; 人类
Bisteau X, Paternot S, Colleoni B, Ecker K, Coulonval K, De Groote P, et al. CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point. PLoS Genet. 2013;9:e1003546 pubmed 出版商
  • 免疫印迹; 人类; 图 s1e
Comstock C, Augello M, Goodwin J, de Leeuw R, Schiewer M, Ostrander W, et al. Targeting cell cycle and hormone receptor pathways in cancer. Oncogene. 2013;32:5481-91 pubmed 出版商
  • 免疫印迹; 人类
Greussing R, Hackl M, Charoentong P, Pauck A, Monteforte R, Cavinato M, et al. Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts. BMC Genomics. 2013;14:224 pubmed 出版商
  • 免疫印迹; 小鼠
Mitterberger M, Zwerschke W. Mechanisms of resveratrol-induced inhibition of clonal expansion and terminal adipogenic differentiation in 3T3-L1 preadipocytes. J Gerontol A Biol Sci Med Sci. 2013;68:1356-76 pubmed 出版商
  • 免疫印迹; 人类; 1:200
Liu L, Xu Y, Reiter R. Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63. Bone. 2013;55:432-8 pubmed 出版商
  • 免疫组化; 人类; 1:10
Hawryluk E, Baran J, Gerami P, Sepehr A. 'Monster cell' melanoma with pulmonary metastasis and cyclin D1 amplification. J Cutan Pathol. 2013;40:61-5 pubmed 出版商
  • 免疫组化; 小鼠; 1:100
Souza C, Gamba C, Campos C, Lopes M, Ferreira M, Andrade S, et al. Carboplatin delays mammary cancer 4T1 growth in mice. Pathol Res Pract. 2013;209:24-9 pubmed 出版商
  • 免疫组化; 人类; 1:700
Naganuma S, Whelan K, Natsuizaka M, Kagawa S, Kinugasa H, Chang S, et al. Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma. Am J Cancer Res. 2012;2:459-75 pubmed
  • 免疫印迹; 人类; 1:500
Wang J, Thiere M, Henne Bruns D, Knippschild U, Kornmann M. Inhibition of pancreatic cancer cell growth in vivo using a tetracycline-inducible cyclin D1 antisense expression system. Pancreas. 2013;42:141-8 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Ramis G, Thomàs Moyà E, Fernandez De Mattos S, Rodriguez J, Villalonga P. EGFR inhibition in glioma cells modulates Rho signaling to inhibit cell motility and invasion and cooperates with temozolomide to reduce cell growth. PLoS ONE. 2012;7:e38770 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1
Chen S, Fu S, Hsu S, Huang Y, Hsu B. Synergistic Effect of Hyperglycemia and p27(kip1) Suppression on Adult Mouse Islet Beta Cell Replication. Int J Endocrinol. 2012;2012:417390 pubmed 出版商
  • 免疫印迹; 小鼠
Casimiro M, Crosariol M, Loro E, Ertel A, Yu Z, Dampier W, et al. ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J Clin Invest. 2012;122:833-43 pubmed 出版商
  • 免疫印迹; 小鼠
Wang X, Sistrunk C, Miliani de Marval P, Kim Y, Rodriguez Puebla M. Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development. Cell Cycle. 2012;11:335-42 pubmed 出版商
  • 免疫组化; 人类; 1:50
Zhang L, Jiang F, Xu L, Wang J, Bai J, Yin R, et al. The role of cyclin D1 expression and patient's survival in non-small-cell lung cancer: a systematic review with meta-analysis. Clin Lung Cancer. 2012;13:188-95 pubmed 出版商
  • 免疫印迹; 人类
Obrador Hevia A, Serra Sitjar M, Rodriguez J, Villalonga P, Fernandez De Mattos S. The tumour suppressor FOXO3 is a key regulator of mantle cell lymphoma proliferation and survival. Br J Haematol. 2012;156:334-45 pubmed 出版商
  • 免疫印迹; 人类
Berdiel Acer M, Bohem M, Lopez Doriga A, Vidal A, Salazar R, Martínez Iniesta M, et al. Hepatic carcinoma-associated fibroblasts promote an adaptative response in colorectal cancer cells that inhibit proliferation and apoptosis: nonresistant cells die by nonapoptotic cell death. Neoplasia. 2011;13:931-46 pubmed
  • 免疫印迹; 人类
Gierut J, Zheng Y, Bie W, Carroll R, Ball Kell S, Haegebarth A, et al. Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane. Gastroenterology. 2011;141:1371-80, 1380.e1-2 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Zhao L, Jiao Q, Yang P, Chen X, Zhang J, Zhao B, et al. Metabotropic glutamate receptor 5 promotes proliferation of human neural stem/progenitor cells with activation of mitogen-activated protein kinases signaling pathway in vitro. Neuroscience. 2011;192:185-94 pubmed 出版商
  • 免疫组化; 人类; 1:200
Mellai M, Piazzi A, Caldera V, Monzeglio O, Cassoni P, Valente G, et al. IDH1 and IDH2 mutations, immunohistochemistry and associations in a series of brain tumors. J Neurooncol. 2011;105:345-57 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Cerliani J, Guillardoy T, Giulianelli S, Vaque J, Gutkind J, Vanzulli S, et al. Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer. Cancer Res. 2011;71:3720-31 pubmed 出版商
  • 免疫印迹; 小鼠
de Carcer G, Escobar B, Higuero A, Garcia L, Ansón A, Pérez G, et al. Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. Mol Cell Biol. 2011;31:1225-39 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Yap T, Walton M, Hunter L, Valenti M, de Haven Brandon A, Eve P, et al. Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. Mol Cancer Ther. 2011;10:360-71 pubmed 出版商
  • 免疫印迹; 人类
Liu L, Zhu Y, Xu Y, Reiter R. Melatonin delays cell proliferation by inducing G1 and G2 /M phase arrest in a human osteoblastic cell line hFOB 1.19. J Pineal Res. 2011;50:222-31 pubmed 出版商
  • 免疫组化; 人类
Fan Y, Zhao Z, Fu J, Chen C, Sun W. Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo. Hepatobiliary Pancreat Dis Int. 2010;9:414-22 pubmed
  • 免疫印迹; 小鼠; 1:500
Bottino M, Cerliani J, Rojas P, Giulianelli S, Soldati R, Mondillo C, et al. Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects. Breast Cancer Res Treat. 2011;126:621-36 pubmed 出版商
  • 免疫印迹; 大鼠
Rafacho A, Quallio S, Ribeiro D, Taboga S, Paula F, Boschero A, et al. The adaptive compensations in endocrine pancreas from glucocorticoid-treated rats are reversible after the interruption of treatment. Acta Physiol (Oxf). 2010;200:223-35 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Tian Y, Liu Y, Chen X, Kang Q, Zhang J, Shi Q, et al. AMN082 promotes the proliferation and differentiation of neural progenitor cells with influence on phosphorylation of MAPK signaling pathways. Neurochem Int. 2010;57:8-15 pubmed 出版商
  • 免疫印迹; 人类
Heiferman M, Salabat M, Ujiki M, Strouch M, Cheon E, Silverman R, et al. Sansalvamide induces pancreatic cancer growth arrest through changes in the cell cycle. Anticancer Res. 2010;30:73-8 pubmed
  • 免疫印迹; 小鼠; 1:500
Gonzalez Pardo V, Martin D, Gutkind J, Verstuyf A, Bouillon R, de Boland A, et al. 1 Alpha,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo. Endocrinology. 2010;151:23-31 pubmed 出版商
  • 免疫印迹; 大鼠; 1:1000
Chen X, Tian Y, Yao L, Zhang J, Liu Y. Hypoxia stimulates proliferation of rat neural stem cells with influence on the expression of cyclin D1 and c-Jun N-terminal protein kinase signaling pathway in vitro. Neuroscience. 2010;165:705-14 pubmed 出版商
  • 免疫印迹; 人类; 1:250; 图 2
Chimploy K, Díaz G, Li Q, Carter O, Dashwood W, Mathews C, et al. E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. Int J Cancer. 2009;125:2086-94 pubmed 出版商
  • 免疫印迹; 人类
Lau C, Koty Z, Nalbantoglu J. Differential response of glioma cells to FOXO1-directed therapy. Cancer Res. 2009;69:5433-40 pubmed 出版商
  • 免疫印迹; 人类
Li Y, Tan X, Dai C, Stolz D, Wang D, Liu Y. Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am Soc Nephrol. 2009;20:1907-18 pubmed 出版商
  • 免疫组化; 人类; 1:50
Sarkar R, Hunter I, Rajaganeshan R, Perry S, Guillou P, Jayne D. Expression of cyclin D2 is an independent predictor of the development of hepatic metastasis in colorectal cancer. Colorectal Dis. 2010;12:316-23 pubmed 出版商
  • 免疫印迹; 人类
Ose R, Yanagawa T, Ikeda S, Ohara O, Koga H. PCDH24-induced contact inhibition involves downregulation of beta-catenin signaling. Mol Oncol. 2009;3:54-66 pubmed 出版商
  • 免疫组化; 人类
Dong H, Weisberger J, Liu Z, Tugulea S. Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics. Am J Clin Pathol. 2009;131:586-95 pubmed 出版商
  • 免疫组化; 人类; 1:50
Khoury T, Alrawi S, Ramnath N, Li Q, Grimm M, Black J, et al. Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer. Clin Lung Cancer. 2009;10:58-66 pubmed 出版商
  • 免疫印迹; 大鼠; 1:500
Xuan W, Li Y, Liu G, Ben David Y, Archer M. Interleukin-24 induces expression of beta4 integrin but suppresses anchorage-independent growth of rat mammary tumor cells by a mechanism that is independent of beta4. Mol Cancer Res. 2009;7:433-42 pubmed 出版商
  • 免疫印迹; 人类
Sohn D, Graupner V, Neise D, Essmann F, Schulze Osthoff K, Jänicke R. Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53. Cell Death Differ. 2009;16:869-78 pubmed 出版商
  • 免疫印迹; 小鼠
Frémin C, Bessard A, Ezan F, Gailhouste L, Régeard M, Le Seyec J, et al. Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2. Hepatology. 2009;49:930-9 pubmed 出版商
  • 免疫印迹; 大鼠
Rafacho A, Cestari T, Taboga S, Boschero A, Bosqueiro J. High doses of dexamethasone induce increased beta-cell proliferation in pancreatic rat islets. Am J Physiol Endocrinol Metab. 2009;296:E681-9 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200
  • 免疫印迹; 人类; 1:250
Chu J, Yu S, Hayward S, Chan F. Development of a three-dimensional culture model of prostatic epithelial cells and its use for the study of epithelial-mesenchymal transition and inhibition of PI3K pathway in prostate cancer. Prostate. 2009;69:428-42 pubmed 出版商
  • 免疫印迹; 人类
Tiedemann R, Schmidt J, Keats J, Shi C, Zhu Y, Palmer S, et al. Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo. Blood. 2009;113:4027-37 pubmed 出版商
  • 免疫组化; 人类; 1:400
Vékony H, Roser K, Löning T, Raaphorst F, Leemans C, Van der Waal I, et al. Deregulated expression of p16INK4a and p53 pathway members in benign and malignant myoepithelial tumours of the salivary glands. Histopathology. 2008;53:658-66 pubmed 出版商
  • 免疫印迹; 人类
Wang Z, Qi Y, Chen Q, Yang D, Tang S, Jin X, et al. Cyclin A is essential for the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells. Toxicology. 2009;256:1-6 pubmed 出版商
  • 免疫组化; 人类
Ko E, Kim Y, Lee B, Han J, Song S, Shim Y, et al. Relationship of phospho-pRb (Ser-807/811) level to exposure to tobacco smoke in primary non-small cell lung cancer. Cancer Lett. 2009;274:225-32 pubmed 出版商
  • 免疫印迹; 小鼠; 1:50
Giulianelli S, Cerliani J, Lamb C, Fabris V, Bottino M, Gorostiaga M, et al. Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis. Int J Cancer. 2008;123:2518-31 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
LARREA M, Liang J, Da Silva T, Hong F, Shao S, Han K, et al. Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4. Mol Cell Biol. 2008;28:6462-72 pubmed 出版商
  • 免疫印迹; 人类
Schnier J, Nishi K, Harley W, Gorin F. An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas. J Neurooncol. 2008;89:19-26 pubmed 出版商
  • 免疫印迹; 小鼠
Zheng Y, Bie W, Yang R, Perekatt A, Poole A, Tyner A. Functions of p21 and p27 in the regenerating epithelial linings of the mouse small and large intestine. Cancer Biol Ther. 2008;7:873-9 pubmed
  • 免疫组化; 小鼠
Hatton B, Villavicencio E, Tsuchiya K, Pritchard J, Ditzler S, Pullar B, et al. The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread. Cancer Res. 2008;68:1768-76 pubmed 出版商
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Xia W, Nagase S, Montia A, KALACHIKOV S, Keniry M, Su T, et al. BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer. Cancer Res. 2008;68:1667-74 pubmed 出版商
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Ikari A, Okude C, Sawada H, Yamazaki Y, Sugatani J, Miwa M. TRPM6 expression and cell proliferation are up-regulated by phosphorylation of ERK1/2 in renal epithelial cells. Biochem Biophys Res Commun. 2008;369:1129-33 pubmed 出版商
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Dagvadorj A, Kirken R, Leiby B, Karras J, Nevalainen M. Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo. Clin Cancer Res. 2008;14:1317-24 pubmed 出版商
  • 免疫组化; 人类
Sathyan K, Nalinakumari K, Abraham T, Kannan S. CCND1 polymorphisms (A870G and C1722G) modulate its protein expression and survival in oral carcinoma. Oral Oncol. 2008;44:689-97 pubmed
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Qin X, Zhang H, Zhou X, Wang C, Zhang H, Zhang X, et al. Proliferation and migration mediated by Dkk-1/Wnt/beta-catenin cascade in a model of hepatocellular carcinoma cells. Transl Res. 2007;150:281-94 pubmed
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Kajanne R, Leppa S, Luukkainen P, Ustinov J, Thiel A, Ristimaki A, et al. Hydrocortisone and indomethacin negatively modulate EGF-R signaling in human fetal intestine. Pediatr Res. 2007;62:570-5 pubmed
  • 免疫沉淀; 小鼠
  • 免疫印迹; 小鼠
Santamaria D, Barrière C, Cerqueira A, Hunt S, Tardy C, Newton K, et al. Cdk1 is sufficient to drive the mammalian cell cycle. Nature. 2007;448:811-5 pubmed
  • 免疫组化; 人类; 1:100
Pulcrano M, Boukheris H, Talbot M, Caillou B, Dupuy C, Virion A, et al. Poorly differentiated follicular thyroid carcinoma: prognostic factors and relevance of histological classification. Thyroid. 2007;17:639-46 pubmed
  • 免疫印迹; 人类
Yang D, Qi Y, Chen Q, Wang Z, Jin X, Gao J, et al. The over-expression of p53 H179Y residue mutation causes the increase of cyclin A1 and Cdk4 expression in HELF cells. Mol Cell Biochem. 2007;304:219-26 pubmed
  • 免疫组化; 人类; 1:50
Lebe B, Pabuccuoglu U, Ozer E. The significance of Ki-67 proliferative index and cyclin D1 expression of dysplastic nevi in the biologic spectrum of melanocytic lesions. Appl Immunohistochem Mol Morphol. 2007;15:160-4 pubmed
  • 免疫组化; 人类
Shin S, Lesser M, Rosen P. Hemangiomas and angiosarcomas of the breast: diagnostic utility of cell cycle markers with emphasis on Ki-67. Arch Pathol Lab Med. 2007;131:538-44 pubmed
  • 免疫印迹; 小鼠
Yang Z, Mott S, Rosmarin A. The Ets transcription factor GABP is required for cell-cycle progression. Nat Cell Biol. 2007;9:339-46 pubmed
  • 免疫印迹; 人类; 1:500
Wiseman D, Werner S, Crowell P. Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. J Pharmacol Exp Ther. 2007;320:1163-70 pubmed
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Qi Y, Tu Y, Yang D, Chen Q, Xiao J, Chen Y, et al. Cyclin A but not cyclin D1 is essential for c-myc-modulated cell-cycle progression. J Cell Physiol. 2007;210:63-71 pubmed
  • 免疫印迹; 人类
Paternot S, Dumont J, Roger P. Differential utilization of cyclin D1 and cyclin D3 in the distinct mitogenic stimulations by growth factors and TSH of human thyrocytes in primary culture. Mol Endocrinol. 2006;20:3279-92 pubmed
  • 免疫组化; 人类; 1:200
Wu W, Slomovitz B, Soliman P, Schmeler K, Celestino J, Milam M, et al. Correlation of cyclin D1 and cyclin D3 overexpression with the loss of PTEN expression in endometrial carcinoma. Int J Gynecol Cancer. 2006;16:1668-72 pubmed
  • 免疫组化; 人类; 1:50
Catherwood M, Gonzalez D, Patton C, Dobbin E, Venkatraman L, Alexander H. Improved clonality assessment in germinal centre/post-germinal centre non-Hodgkin's lymphomas with high rates of somatic hypermutation. J Clin Pathol. 2007;60:524-8 pubmed
  • 免疫印迹; 大鼠; 1:200
Friedrichsen B, Neubauer N, Lee Y, Gram V, Blume N, Petersen J, et al. Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways. J Endocrinol. 2006;188:481-92 pubmed
  • 免疫组化; 人类
Pich A, Fraire F, Fornari A, Bonino L, Godio L, Bortolin P, et al. Intrasinusoidal bone marrow infiltration and splenic marginal zone lymphoma: a quantitative study. Eur J Haematol. 2006;76:392-8 pubmed
  • 免疫印迹; 大鼠
Shan Y, Zhou W, Fu X, Yan H, Yang W, Liu S, et al. The role of p28GANK in rat oval cells activation and proliferation. Liver Int. 2006;26:240-7 pubmed
  • 免疫印迹; 人类
Toschi E, Bacigalupo I, Strippoli R, Chiozzini C, Cereseto A, Falchi M, et al. HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway. Mol Biol Cell. 2006;17:1985-94 pubmed
  • 免疫组化; 人类; 1:50
Kanungo A, Medeiros L, Abruzzo L, Lin P. Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis. Mod Pathol. 2006;19:25-33 pubmed
  • 免疫组化; 人类
  • 免疫印迹; 人类
Hui A, Or Y, Takano H, Tsang R, To K, Guan X, et al. Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma. Cancer Res. 2005;65:8125-33 pubmed
  • 免疫印迹; 人类
Mermelshtein A, Gerson A, Walfisch S, Delgado B, Shechter Maor G, Delgado J, et al. Expression of D-type cyclins in colon cancer and in cell lines from colon carcinomas. Br J Cancer. 2005;93:338-45 pubmed
  • 免疫印迹; 人类; 1:200
Raynaud F, Whittaker S, Fischer P, McClue S, Walton M, Barrie S, et al. In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202. Clin Cancer Res. 2005;11:4875-87 pubmed
  • 免疫组化; 人类; 1:20
Schmitt Graeff A, Ertelt Heitzmann V, Allgaier H, Olschewski M, Nitschke R, Haxelmans S, et al. Coordinated expression of cyclin D1 and LEF-1/TCF transcription factor is restricted to a subset of hepatocellular carcinoma. Liver Int. 2005;25:839-47 pubmed
  • 免疫组化; 大鼠
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  • 免疫印迹; 大鼠; 1:200; 图 1b
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产品信息
产品类型 :
抗体
产品名称 :
细胞周期蛋白D1单克隆抗体(DCS-6)
目录# :
MA1-24750
规格 :
100微升
定价 :
美国435
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
Human, Mouse, Non-human primate, Rat
应用 :
Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:200
物种 :
Human, Mouse, Non-human primate, Rat
克隆 :
DCS-6
抗体亚型 :
IgG2a
储存 :
短期存放在4°C。 为长期储存, 存放在-20°C, 避免反复冷冻/解冻
描述 :
Cyclin D1 (PRAD-1, bcl-1) is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein. Cyclin D1 is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL). In addition, cyclin D1 positively regulates protein phosphorylation, mammary gland epithelial cell proliferation, and fat cell differentiation. In humans, the CCND1 gene encoding cyclin D1 is present on chromosome 11. Cyclin D1 is a cytoplasmic and nuclear protein that is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation. D-type cyclin-CDK complexes act to inactivate the growth-suppressive function of the Rb protein through its phosphorylation, and titrate CDK inhibitors such as p21Cip1 and p27Kip1. Without growth factor-mediated stimulation, Cyclin D1 is unstable, and undergoes ubiquitin-mediated degradation, which is triggered by its phosphorylation. Cyclin D1 destabilization participates in G1/S phase arrest. The Cyclin D1 protein belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The Cyclin D1 protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities.
免疫原 :
重组, 全长人类蛋白
格式 :
液体
应用w/稀释 :
Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: Assay-dependent, Western Blot: 1:200
别名 :
AI327039; B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1; BCL-1 oncogene; CCND1; CCND1 protein; cD1; cDNA; CycD1; cyclin D1; Cyl-1; D11S287E; FLJ93625; G1/S-specific cyclin-D1; mRNA; PRAD1; PRAD-1; PRAD1 oncogene; U21B31
更多信息或购买 :
公司信息
赛默飞世尔
上海浦东新金桥路27号7号楼
analyze.cn@thermofisher.com
http://www.thermo.com.cn
1084193588
公司总部: 美国